Engineered Bacteriophage as a Delivery Vehicle for Antibacterial Protein, SASP [PDF]
Pharmaceuticals, 2021 The difficulties in developing novel classes of antibacterials is leading to a resurgence of interest in bacteriophages as therapeutic agents, and in particular engineered phages that can be optimally designed. Here, pre-clinical microbiology assessment is presented of a Staphylococcus aureus phage engineered to deliver a gene encoding an antibacterial
Cass, James +2 more
openaire +3 more sources
TREM1/3 deficiency impairs tissue repair after acute kidney injury and mitochondrial metabolic flexibility in tubular epithelial cells [PDF]
, 2019 Long-term sequelae of acute kidney injury (AKI) are associated with incomplete recovery of renal function and the development of chronic kidney disease (CKD), which can be mediated by aberrant innate immune activation, mitochondrial pathology, and ...
Borrelli, Cristiana +10 more
core +2 more sources
Molecular & Cellular Oncology, 2020 The breast tumors that are most difficult to eradicate with chemotherapy have wild-type TP53 and preferentially enter senescence after treatment. One factor contributing to the persistence of senescent cells in residual disease: acquisition of a novel ...
Crystal A. Tonnessen-Murray +1 more
doaj +1 more source
The light and shadow of senescence and inflammation in cardiovascular pathology and regenerative medicine [PDF]
, 2017 Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised ...
Cavarretta, Elena +9 more
core +4 more sources
Role of cellular senescence and NOX4-mediated oxidative stress in systemic sclerosis pathogenesis. [PDF]
, 2015 Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by progressive fibrosis of skin and numerous internal organs and a severe fibroproliferative vasculopathy resulting frequently in severe disability and high mortality.
A Diazdeleon +130 more
core +2 more sources
The Rbm38-p63 feedback loop is critical for tumor suppression and longevity. [PDF]
, 2018 The RNA-binding protein Rbm38 is a target of p63 tumor suppressor and can in-turn repress p63 expression via mRNA stability. Thus, Rbm38 and p63 form a negative feedback loop.
Chen, Mingyi +5 more
core +1 more source
AISA can control the inflammatory facet of SASP
Mechanisms of Ageing and Development, 2020 Senescent cells have been suspected, because of their secretory phenotype (SASP or Senescence Associated Secretory Profile), to contribute to the extension of the chronic inflammatory condition leading to unhealthy aging processes. AISA (Anti-Inflammatory Senescence Actives) monoterpens have been characterized as possessing anti-inflammatory capacities
Patrizia A, d'Alessio, Marie C, Béné
openaire +3 more sources
The Dynamic Process and Its Dual Effects on Tumors of Therapy-Induced Senescence
Cancer Management and Research, 2020 Chenxi Liao,1,* Yin Xiao,2,* Lingbo Liu1 1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People’s Republic of China; 2Cancer Center, Union Hospital, Tongji Medical ...
Liao C, Xiao Y, Liu L
doaj
Senescence drives non-cell autonomous tumorigenesis in the pituitary gland
Molecular & Cellular Oncology, 2018 Novel detrimental functions of senescent cells have been recently uncovered in the context of cancer development and progression, which they mainly exert through the secretion of several pro-tumorigenic factors.
Jose Mario Gonzalez-Meljem +1 more
doaj +1 more source
Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence [PDF]
, 2019 The activation of cellular senescence throughout the lifespan promotes tumor suppression, whereas the persistence of senescent cells contributes to aspects of aging.
Diekman, Brian O. +9 more
core +3 more sources