Results 51 to 60 of about 29,788 (255)

Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window [PDF]

, 2020
During the implantation window, the endometrium becomes poised to transition to a pregnant state, a process driven by differentiation of stromal cells into decidual cells (DC).
Brighton, Paul (Paul J.), Brosens, Jan J., Diniz-da-Costa, Maria, Ewington, Lauren J., Fishwick, Katherine J., Kong, Chow-Seng, Lipecki, Julia, Lucas, Emma S., Muter, Joanne, Odendaal, Joshua, Ott, Sascha, Quenby, Siobhan, Vrljicak, Pavle   +12 more
core   +1 more source

The role of senescence-associated secretory phenotype (SASP) in cellular senescene

Acta Biochimica Indonesiana, 2021
Cellular senescence is one of the defense mechanisms of cells against oncogenic signals by permanently stopping the proliferation of the cell. Senescence cells show a similar characteristic, one of them is senescence-associated secretory phenotype (SASP).
Filda Vionita Irene de Lime, Novi Silvia Hardiany   +1 more
doaj   +1 more source

Crystalline Undulator with a Small Amplitude and a Short Period

, 2013
The crystalline undulator is a single crystal with periodically bent crystallographic planes. If ultrarelativistic charged particles channel through such a crystal, they emit hard radiation of undulator type.
Kostyuk, Andriy
core   +1 more source

Bone marrow senescence and the microenvironment of hematological malignancies [PDF]

, 2020
Senescence is the irreversible arrest of cell proliferation that has now been shown to play an important role in both health and disease. With increasing age senescent cells accumulate throughout the body, including the bone marrow and this has been ...
Bowles, Kristian M., Hellmich, Charlotte, Moore, Jamie A., Rushworth, Stuart A.   +3 more
core   +1 more source

Role of Clusterin/NF-κB in the secretion of senescence-associated secretory phenotype in Cr(VI)-induced premature senescent L-02 hepatocytes

Ecotoxicology and Environmental Safety, 2021
Hexavalent chromium [Cr(VI)] and its compounds have caused serious environmental pollution and health damage. Senescent cells can actively change the surrounding environment by secreting some factors, which are called senescence associated secretory ...
Yuehui Liang, Ningjuan Liang, Yu Ma, Sixuan Tang, Shuzi Ye, Fang Xiao   +5 more
doaj   +1 more source

Senescence and Cancer: Role of Nitric Oxide (NO) in SASP [PDF]

Cancers, 2020
Cellular senescence is a cell state involved in both physiological and pathological processes such as age-related diseases and cancer. While the mechanism of senescence is now well known, its role in tumorigenesis still remains very controversial. The positive and negative effects of senescence on tumorigenesis depend largely on the diversity of the ...
Mabrouk, Nesrine, Ghione, Silvia, Laurens, Véronique, Plenchette, Stéphanie, Bettaieb, Ali, Paul, Catherine   +5 more
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Arsenite exposure induces premature senescence and senescence-associated secretory phenotype (SASP) in human hepatocyte-derived cell line Huh-7

Environmental Health and Preventive Medicine
Background: Chronic arsenite exposure has been known to induce cancer in various organs; however, the underlying mechanisms remain elusive. The characteristic feature of carcinogenesis due to arsenic exposure is that the disease develops after a ...
Kazuyuki Okamura, Miyuki Sato, Takehiro Suzuki, Keiko Nohara   +3 more
doaj   +1 more source

(-)-α-Bisabolol inhibits D-Gal-induced HSF cellular senescence in vitro and prevents skin aging in vivo by reducing SASP [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): To study the anti-aging effect of (-)-α-bisabolol ((-)-α-bis) on the skin and preliminarily clarify its mechanism. Materials and Methods: Human skin fibroblasts (HSF) were induced senescence by D-Galactose.
Meixing He, Panyu Zhou, Hankun Chen, Junhong Zhang, Yating Zhang, Xianhui Zheng, Wei Zhu, Ling Han   +7 more
doaj   +1 more source

Senescence Can Be BETter without the SASP? [PDF]

Cancer Discovery, 2016
Abstract Summary: Global remodeling of the chromatin landscape occurs during senescence, although its functional consequence is still unclear. In this issue, Tasdemir and colleagues show that the epigenetic regulator BRD4 is required for expression of the proinflammatory senescence-associated secretory phenotype and immune clearance of ...
Maria Grazia, Vizioli, Peter D, Adams
openaire   +2 more sources