Results 41 to 50 of about 16,976 (234)

Semaphorin-7A diminishes HLF proliferation and migration.

, 2017
HLF derived from non-fibrotic lungs were treated with either control or semaphorin-7A siRNA and cultured in 1% or 10% FBS for 48 h. A/ BrdU was incubated with cells for 6 h.
Elizabeth A. Kelly (429798), Stephane Esnault (24104), Mats W. Johansson (2584933), Elizabeth E. Torr (3663346), Nathan Sandbo (777206), Ksenija Bernau (3663349), Nizar N. Jarjour (103237)   +6 more
core   +1 more source

Wiring olfaction: the cellular and molecular mechanisms that guide the development of synaptic connections from the nose to the cortex

Frontiers in Neuroscience, 2009
Within the central nervous system, the olfactory system fascinates by its developmental and physiological particularities, and is one of the most studied models to understand the mechanisms underlying the guidance of growing axons to their appropriate ...
Fernando De Castro
doaj   +1 more source

Semaphorins and their Signaling Mechanisms [PDF]

, 2016
Semaphorins are extracellular signaling proteins that are essential for the development and maintenance of many organs and tissues. The more than 20-member semaphorin protein family includes secreted, transmembrane and cell surface-attached proteins with diverse structures, each characterized by a single cysteine-rich extracellular sema domain, the ...
Laura Taylor, Alto, Jonathan R, Terman
openaire   +2 more sources

Neuropilin-mediated neural crest cell guidance is essential to organise sensory neurons into segmented dorsal root ganglia

, 2009
The peripheral nervous system (PNS) of higher vertebrates is segmented to align the spinal nerve roots with the vertebrae. This co-patterning is set up during embryogenesis, when vertebrae develop from the sclerotome layer of the metameric somites, and ...
Maden, CH, Christiana Ruhrberg, Quenten Schwarz, Davidson, K., Schwarz, Q, Ruhrberg, C., Kathryn Davidson, Maden, C., Davidson, K, Ruhrberg, C, Schwarz, Q., Charlotte H. Maden   +11 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

{alpha}2-Chimaerin, cyclin-dependent kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse

, 2004
Neurite outgrowth is influenced by positive and negative signals that include the semaphorins, an important family of axonal outgrowth inhibitors. Here we report that the Rac GTPase activating protein (GAP){alpha}2-chimaerin is involved in Semaphorin 3A (
Eickholt, B, Teo, M, Lim, L, Ferrari, G, Eickholt, Britta, Jacobs, Tom, Leung, Thomas, Jacobs, T., Leung, T., Leung, T, Eickholt, B., Lim, L., Hall, Christine, Qi, R Z, Teo, M., Monfries, C, Jacobs, T, Brown, Matthew, Monfries, Clinton, Teo, Mabel, Qi, Robert Z., Ferrari, G., Qi, R.Z., Lim, Louis, Brown, M., Hall, C., Ferrari, Giovanna, Hall, C, Brown, M, Monfries, C.   +29 more
core   +1 more source

Making connections

eLife, 2014
Deleting a gene called Sema5A, which has been linked to autism in humans, causes neurons to form more connections in mice, and also alters how these mutant mice interact with other mice.
Justin W Kenney, Paul W Frankland
doaj   +1 more source

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, EarlyView.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

Semaphorin-7A reduces serum-induced ERK and p38 phosphorylation in HLF.

, 2017
HLF derived from non-fibrotic lungs were treated with control-siRNA (Ctrl.) or semaphorin7A-siRNA (sema7A) for 24 h before starvation in BSA for 24 h. A/ Then cells were activated with 1% or 10% FBS for 15 min. ERK phosphorylation (P-ERK) was analyzed by
Elizabeth A. Kelly (429798), Stephane Esnault (24104), Mats W. Johansson (2584933), Elizabeth E. Torr (3663346), Nathan Sandbo (777206), Ksenija Bernau (3663349), Nizar N. Jarjour (103237)   +6 more
core   +1 more source

Glial and neuronal Semaphorin signaling instruct the development of a functional myotopic map for Drosophila walking

eLife, 2016
Motoneurons developmentally acquire appropriate cellular architectures that ensure connections with postsynaptic muscles and presynaptic neurons. In Drosophila, leg motoneurons are organized as a myotopic map, where their dendritic domains represent the ...
Durafshan Sakeena Syed, Swetha B.M. Gowda, O Venkateswara Reddy, Heinrich Reichert, K VijayRaghavan   +4 more
doaj   +1 more source