Results 31 to 40 of about 16,976 (234)
Semaphorin-3E/plexinD1 axis in allergic asthma
Advances in Biomedical and Health Sciences, 2022 Semaphorins are cell-membrane bound or secretory proteins that regulate cell migration, differentiation, proliferation, and morphology. Semaphorins are guidance cues that have either repulsive or attractive effects on growth cones and thus determine ...
Mojdeh Matloubi +4 more
doaj +1 more source
eLife, 2014 Human SEMAPHORIN 5A (SEMA5A) is an autism susceptibility gene; however, its function in brain development is unknown. In this study, we show that mouse Sema5A negatively regulates synaptogenesis in early, developmentally born, hippocampal dentate granule
Yuntao Duan +6 more
doaj +1 more source
SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability
Nature Communications, 2023 Innervation of the hypothalamic median eminence by Gonadotropin-Releasing Hormone (GnRH) neurons is vital to ensure puberty onset and successful reproduction.
Antonella Lettieri +17 more
doaj +1 more source
Cells, 2023 Maternal hyperhomocysteinemia causes the disruption of placental blood flow and can lead to serious disturbances in the formation of the offspring’s brain.
Dmitrii S. Vasilev +9 more
doaj +1 more source
The role of the semaphorins in cancer [PDF]
Cell Adhesion & Migration, 2016 The semaphorins were initially characterized as axon guidance factors, but have subsequently been implicated also in the regulation of immune responses, angiogenesis, organ formation, and a variety of additional physiological and developmental functions.
Gera, Neufeld +6 more
openaire +2 more sources
Semaphorin-7A siRNA reduces semaphorin-7A present in non-fibrotic human lung fibroblasts (HLF).
, 2017 A/ and B/ Surface semaphorin-7A was analyzed by flow cytometry. Histograms are representative of 3 experiments. A/ HLF derived from non-fibrotic lungs were cultured in 1% or 10% FBS or TGF-ß1 (1 ng/ml) for 24 h.
Elizabeth A. Kelly (429798) +6 more
core +1 more source
Downregulation of Endothelial Plexin A4 Under Inflammatory Conditions Impairs Vascular Integrity
Frontiers in Cardiovascular Medicine, 2021 Objective: Besides hyperlipidemia, inflammation is an important determinant in the initiation and the progression of atherosclerosis. As Neuroimmune Guidance Cues (NGCs) are emerging as regulators of atherosclerosis, we set out to investigate the ...
Dianne Vreeken +10 more
doaj +1 more source
Semaphorin-7A expression is inversely correlated with periostin expression in HLF.
, 2017 Expression of semaphorin-7A (sema7A), periostin, fibronectin and collagen-1 (COL1A1) were measured by real-time PCR in fibroblasts from non-fibrotic (●, n = 7) and IPF lung (■, n = 6).
Elizabeth A. Kelly (429798) +6 more
core +1 more source
Frontiers in Immunology, 2021 Semaphorins are a group of proteins that have been studied extensively for their critical function in neuronal development. They have been shown to regulate airway development, tumorigenesis, autoimmune diseases, and the adaptive immune response. Notably,
Shreya M. Kanth +2 more
doaj +1 more source
, 2019 Background: Semaphorin-3A (Sema3A) and Semaphorin-7A (Sema7A) play crucial roles in immune system by inhibiting T cell proliferation and leading to the secretion of pro-inflammatory cytokines.
Hai-Feng Pan (112460) +7 more
core +1 more source