Results 31 to 40 of about 14,138 (186)
Semaphorins in Angiogenesis and Autoimmune Diseases: Therapeutic Targets?
Frontiers in Immunology, 2020 The axonal guidance molecules, semaphorins, have been described to function both physiologically and pathologically outside of the nervous system. In this review, we focus on the vertebrate semaphorins found in classes 3 through 7 and their roles in ...
Vijaya Iragavarapu-Charyulu +2 more
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Genome biology, 2006 Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-rich semaphorin protein domains, that have important roles in a variety of tissues. Humans have 20 semaphorins, Drosophila has five, and two are known from DNA viruses; semaphorins are also found in nematodes and crustaceans but not in non-animals.
Yazdani, Umar, Terman, Jonathan R
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Semaphorin 3C and Its Receptors in Cancer and Cancer Stem-Like Cells
Biomedicines, 2018 Neurodevelopmental programs are frequently dysregulated in cancer. Semaphorins are a large family of guidance cues that direct neuronal network formation and are also implicated in cancer. Semaphorins have two kinds of receptors, neuropilins and plexins.
Jing Hao, Jennifer S. Yu
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Semaphorins in Lung Cancer [PDF]
Journal of Thoracic Oncology, 2006 The secreted class 3 semaphorins, which include SEMA3F, a tumor-suppressor gene in lung cancer, were initially identified as molecules involved in the repulsion of developing nerve growth cones. These molecules are part of a larger family that includes transmembrane and membrane-associated proteins, some of which are expressed widely and implicated in ...
Clarhaut, Jonathan +2 more
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Semaphorin 3F expression is reduced in pregnancy complicated by preeclampsia. An observational clinical study. [PDF]
PLoS ONE, 2017 BACKGROUND AND OBJECTIVE:Preeclampsia is a systemic disorder, affecting 2-10% of pregnancies, characterized by a deregulated pro- and anti-angiogenic balance. Semaphorin 3F is an angiogenesis inhibitor.
Giovanni Stallone +10 more
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Semaphorin-3E/plexinD1 axis in allergic asthma
Advances in Biomedical and Health Sciences, 2022 Semaphorins are cell-membrane bound or secretory proteins that regulate cell migration, differentiation, proliferation, and morphology. Semaphorins are guidance cues that have either repulsive or attractive effects on growth cones and thus determine ...
Mojdeh Matloubi +4 more
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eLife, 2014 Human SEMAPHORIN 5A (SEMA5A) is an autism susceptibility gene; however, its function in brain development is unknown. In this study, we show that mouse Sema5A negatively regulates synaptogenesis in early, developmentally born, hippocampal dentate granule
Yuntao Duan +6 more
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SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability
Nature Communications, 2023 Innervation of the hypothalamic median eminence by Gonadotropin-Releasing Hormone (GnRH) neurons is vital to ensure puberty onset and successful reproduction.
Antonella Lettieri +17 more
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Cells, 2023 Maternal hyperhomocysteinemia causes the disruption of placental blood flow and can lead to serious disturbances in the formation of the offspring’s brain.
Dmitrii S. Vasilev +9 more
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Downregulation of Endothelial Plexin A4 Under Inflammatory Conditions Impairs Vascular Integrity
Frontiers in Cardiovascular Medicine, 2021 Objective: Besides hyperlipidemia, inflammation is an important determinant in the initiation and the progression of atherosclerosis. As Neuroimmune Guidance Cues (NGCs) are emerging as regulators of atherosclerosis, we set out to investigate the ...
Dianne Vreeken +10 more
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