Results 11 to 20 of about 16,976 (234)
Molecular and Cellular Endocrinology, 2016 Semaphorin molecules regulate cell adhesion and motility in a wide variety of cell types and are therefore involved in numerous processes including axon guidance, angiogenesis, cardiogenesis, tumor growth, and immune response. Increasing evidence points to a role of transmembrane, membrane-associated and soluble semaphorins during bone development as ...
Verlinden, Lieve +2 more
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Semaphorin Breaks Symmetry [PDF]
Neuron, 2011 Axon-dendrite polarity is likely instructed by extrinsic cues in the developing nervous system, though the mechanisms governing this process remain to be fully elucidated. In this issue of Neuron, Shelly et al. show that the axon guidance cue Semaphorin 3A can promote dendrite growth by inhibiting axon specification.
Howell, Audrey S., Shen, Kang
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Control of semaphorin signaling
Current Opinion in Neurobiology, 2002 Receptor complexes for the chemorepellent factors of the semaphorin family activate intracellular pathways that trigger actin rearrangements underlying growth cone collapse and repellent behavior. Some evidence has been provided for a complex and dynamic pattern of interaction between members of the small Rho guanosine triphosphatases and plexin ...
Castellani, Valérie, Rougon, Geneviève
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The association of semaphorin 5A with lymph node metastasis and adverse prognosis in cervical cancer
Cancer Cell International, 2018 Background Semaphorin 5A has been linked to tumor growth, invasion, and metastasis in pancreatic cancer. However, the role of semaphorin 5A in cervical cancer is not known. Our aim is to investigate the prognostic value of semaphorin 5A and its potential
Jian-Bing Xiao +8 more
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Immune semaphorins: a new area of semaphorin research [PDF]
Journal of Cell Science, 2003 The semaphorin family comprises soluble and membrane-bound proteins originally identified as axonal guidance cues that function during neuronal development. Emerging evidence suggests that a subset of semaphorins, called'immune semaphorins', function in the immune system. The class IV semaphorins Sema4D/CD100 and Sema4A use CD72 and Tim-2, respectively,
Atsushi, Kumanogoh, Hitoshi, Kikutani
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Semaphorin 7a participants in pterygium by regulating vascular endothelial growth factor [PDF]
International Journal of Ophthalmology, 2019 AIM: To investigate the relationship between semaphorin 7a expression and cell proliferation and migration in pterygium fibroblasts. METHODS: Twenty-six patients with surgically diagnosed pterygium were enrolled, including 15 cases of primary pterygium ...
Yun-Fei Han +9 more
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Frontiers in Neural Circuits, 2020 Fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates local translation in dendrites and spines for synaptic plasticity. In axons, FMRP is implicated in axonal extension and axon guidance.
Masaru Takabatake +2 more
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Semaphorins and tumor angiogenesis [PDF]
Angiogenesis, 2009 Semaphorins belong to a large family of proteins well-conserved along evolution from viruses to mammalians. Secreted and membrane-bound semaphorins participate in a wide range of biological phenomena including development and regeneration of nervous system, cardiovascular development, and immune system activities.
Serini, Guido +3 more
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Neuropilin 1 Regulation of Vascular Permeability Signaling
Biomolecules, 2021 The vascular endothelium acts as a selective barrier to regulate macromolecule exchange between the blood and tissues. However, the integrity of the endothelium barrier is compromised in an array of pathological settings, including ischemic disease and ...
Alison Domingues, Alessandro Fantin
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Molecular Therapy: Oncolytics, 2021 Helicobacter pylori (H. pylori) infection is the strongest risk factor for the occurrence and development of gastric carcinoma. However, the molecular mechanism underlying H. pylori-induced pathogenesis has not yet been fully characterized.
Guoqing Pan +9 more
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