Results 21 to 30 of about 16,976 (234)

Semaphorins in Angiogenesis and Autoimmune Diseases: Therapeutic Targets?

Frontiers in Immunology, 2020
The axonal guidance molecules, semaphorins, have been described to function both physiologically and pathologically outside of the nervous system. In this review, we focus on the vertebrate semaphorins found in classes 3 through 7 and their roles in ...
Vijaya Iragavarapu-Charyulu, Ewa Wojcikiewicz, Alexandra Urdaneta   +2 more
doaj   +1 more source

Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells [PDF]

, 2008
Neuropilin (NRP) receptors and their class 3 semaphorin (SEMA3) ligands play well-established roles in axon guidance, with loss of NRP1, NRP2, SEMA3A or SEMA3F causing defasciculation and errors in growth cone guidance of peripherally projecting nerves ...
Howard, Beatrice, Christiana Ruhrberg, Quenten Schwarz, Britta J. Eickholt, Beatrice Howard, Vieira, J., Vieira, Joaquim M.; id_orcid, Ruhrberg, C., Howard, B, Ruhrberg, Christiana, Vieira, JM, Schwarz, Quenten, Joaquim M. Vieira, Eickholt, BJ, Schwarz, Q, Eickholt, Britta J., Howard, B., Eickholt, B., Ruhrberg, C, Schwarz, Q.P.   +19 more
core   +1 more source

Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2-skewed immune polarization. [PDF]

J Pathol
Abstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Takada M, Sashikawa-Kimura M, Ohno Y, Hossain MR, Xie X, Iwabuchi K, Komine M, Ohtsuki M, Imokawa G.   +8 more
europepmc   +2 more sources

Urinary semaphorin 3A as an early biomarker to predict contrast-induced acute kidney injury in patients undergoing percutaneous coronary intervention

Brazilian Journal of Medical and Biological Research, 2018
Contrast-induced acute kidney injury (CI-AKI) is a serious complication of diagnostic coronary angiograph and percutaneous coronary intervention (PCI).
Li Ning, Zhiguo Li, Dianjun Wei, Haiyan Chen, Chao Yang, Dawei Wu, Yanchun Wang, Jingwei Zhang   +7 more
doaj   +1 more source

Neuropilin-1/GIPC1 signaling regulates α5β1 integrin traffic and function in endothelial cells [PDF]

, 2009
Neuropilin 1 (Nrp1) is a coreceptor for vascular endothelial growth factor A165 (VEGF-A165, VEGF-A164 in mice) and semaphorin 3A (SEMA3A). Nevertheless, <i>Nrp1</i> null embryos display vascular defects that differ from those of mice lacking ...
Caccavari, Francesca, Valdembri, D., Serini, G., Valdembri, Donatella, Caccavari, F., Caswell Patrick T, Anderson, K.I., Humphries, M.J., Patrick T Caswell, Anderson Kurt I, Anderson, Kurt I., Serini, Guido, Caccavari Francesca, Federico Bussolino, Elena Astanina, Valdembri Donatella, König, I., König, Ireen, Astanina, Elena, Schwarz, J.P., Francesca Caccavari, Jim C Norman, Humphries Martin J, Bussolino, F., Schwarz Juliane P, Guido Serini, Serini Guido, König Ireen, Schwarz, Juliane P., Bussolino, Federico, Kurt I Anderson, Humphries, Martin J., Caswell, Patrick T.; id_orcid, Norman, Jim C., Juliane P Schwarz, Astanina Elena, Astanina, E., Bussolino Federico, Norman, J.C., Donatella Valdembri, Caswell, P.T., Ireen König, Norman Jim C, Martin J Humphries   +43 more
core   +1 more source

Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium

Arthritis Research & Therapy, 2022
Objectives Methotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA). However, the precise mechanisms by which MTX stalls RA progression and alleviates the ensuing disease effects remain unknown. The aim of the present study was
Jumpei Shoda, Shigeru Tanaka, Keishi Etori, Koto Hattori, Tadamichi Kasuya, Kei Ikeda, Yuko Maezawa, Akira Suto, Kotaro Suzuki, Junichi Nakamura, Yoshiro Maezawa, Minoru Takemoto, Christer Betsholtz, Koutaro Yokote, Seiji Ohtori, Hiroshi Nakajima   +15 more
doaj   +1 more source

Semaphorins in Lung Cancer [PDF]

Journal of Thoracic Oncology, 2006
The secreted class 3 semaphorins, which include SEMA3F, a tumor-suppressor gene in lung cancer, were initially identified as molecules involved in the repulsion of developing nerve growth cones. These molecules are part of a larger family that includes transmembrane and membrane-associated proteins, some of which are expressed widely and implicated in ...
Clarhaut, Jonathan, Roche, Joëlle, Drabkin, Harry A.   +2 more
openaire   +2 more sources

Semaphorin 3C and Its Receptors in Cancer and Cancer Stem-Like Cells

Biomedicines, 2018
Neurodevelopmental programs are frequently dysregulated in cancer. Semaphorins are a large family of guidance cues that direct neuronal network formation and are also implicated in cancer. Semaphorins have two kinds of receptors, neuropilins and plexins.
Jing Hao, Jennifer S. Yu
doaj   +1 more source

The semaphorins.

Genome biology, 2006
Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-rich semaphorin protein domains, that have important roles in a variety of tissues. Humans have 20 semaphorins, Drosophila has five, and two are known from DNA viruses; semaphorins are also found in nematodes and crustaceans but not in non-animals.
Yazdani, Umar, Terman, Jonathan R
openaire   +2 more sources

Semaphorin 3F expression is reduced in pregnancy complicated by preeclampsia. An observational clinical study. [PDF]

PLoS ONE, 2017
BACKGROUND AND OBJECTIVE:Preeclampsia is a systemic disorder, affecting 2-10% of pregnancies, characterized by a deregulated pro- and anti-angiogenic balance. Semaphorin 3F is an angiogenesis inhibitor.
Giovanni Stallone, Maria Matteo, Giuseppe Stefano Netti, Barbara Infante, Adelaide Di Lorenzo, Clelia Prattichizzo, Stefania Carlucci, Federica Trezza, Loreto Gesualdo, Pantaleo Greco, Giuseppe Grandaliano   +10 more
doaj   +1 more source