Results 71 to 80 of about 16,976 (234)

New Eukaryotic Semaphorins with Close Homology to Semaphorins of DNA Viruses

Genomics, 1998
Semaphorins were initially described as a family of repulsive guidance molecules in embryonal development. Their basic structure consists of an N-terminal signal sequence, the defining semaphorin domain ofapproximately 500 amino acids, an Ig-like domain,and a variable carboxy-terminus.
C, Lange, T, Liehr, M, Goen, E, Gebhart, B, Fleckenstein, A, Ensser   +5 more
openaire   +2 more sources

Plasma Membrane Remodeling During Microglial Activation: A Hypothesis Linking Microglial Shape and Lipid Droplet Formation

Glia, Volume 74, Issue 8, August 2026.
Microglial morphology changes in response to damage by Aβ and aging result in significant reductions in cell surface area. Transcriptomic analyses suggest that fatty acid synthesis and triacylglycerol formation drive redistribution of surface membrane into intracellular lipid droplets.
G. William Rebeck, Giorgi Shautidze, Jordy Sepulveda, Gracie S. Healey, Priyanka S. Narayan   +4 more
wiley   +1 more source

Structural basis of semaphorin-plexin signalling.

, 2010
Cell-cell signalling of semaphorin ligands through interaction with plexin receptors is important for the homeostasis and morphogenesis of many tissues and is widely studied for its role in neural connectivity, cancer, cell migration and immune responses.
Mitchell, KJ, Kevin J. Mitchell, E. Yvonne Jones, Jones, EY, Siebold, Christian, Bell, CH, Christian Siebold, Robinson, RA, Jones, Edith, Bert J. C. Janssen, Ross A. Robinson, Francesc Pérez-Brangulí, Christian H. Bell, Janssen, BJ, Pérez-Brangulí, F, Siebold, C   +15 more
core   +1 more source

The effect of aerobic exercise and psilocybin following methamphetamine induction on the gene expression of certain semaphorins in female Wistar rats [PDF]

Medical Laboratory Journal
Background: The purpose of the present study was to investigate the effect of aerobic exercise and psilocybin after methamphetamine induction on the gene expression of certain cerebral cortex semaphorins in female Wistar rats.
Fariba Rasannezhad, Asieh Abbassi Daloii, Javad Ziaolhagh, Ahmad Abdi   +3 more
doaj  

Neurocan Inhibits Semaphorin 3F Induced Dendritic Spine Remodeling Through NrCAM in Cortical Neurons

Frontiers in Cellular Neuroscience, 2018
Neurocan is a chondroitin sulfate proteoglycan present in perineuronal nets, which are associated with closure of the critical period of synaptic plasticity.
Vishwa Mohan, Elliott V. Wyatt, Ingo Gotthard, Kristen D. Phend, Simone Diestel, Bryce W. Duncan, Richard J. Weinberg, Ashutosh Tripathy, Patricia F. Maness   +8 more
doaj   +1 more source

Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb

Nature Communications, 2020
Reperfusion injury following myocardial ischemia is aggravated by inflammation and platelet–neutrophil complex formation. Here the authors show that semaphorin 7A binds to platelet GPIb, enhancing platelet–neutrophil interaction and increasing post ...
David Köhler, Tiago Granja, Julia Volz, Michael Koeppen, Harald F. Langer, Georg Hansmann, Ekaterina Legchenko, Tobias Geisler, Tamam Bakchoul, Claudia Eggstein, Helene A. Häberle, Bernhard Nieswandt, Peter Rosenberger   +12 more
doaj   +1 more source

De Novo Genome Assemblies of Four Rainbow Trout Genetic Lines Reveal Structural Variants in Pursuit of a Pangenome Reference

Molecular Ecology Resources, Volume 26, Issue 5, July 2026.
ABSTRACT Rainbow trout (Oncorhynchus mykiss) exhibit extensive genomic diversity shaped by domestication, life history and geographic origin. To advance the development of a comprehensive pangenome reference, we present new de novo genome assemblies of two genetically and ecologically distinct lines: Whale Rock (WR; wild, landlocked, Central California)
Ali Ali, Geoffrey C. Waldbieser, Ramey C. Youngblood, Paul A. Wheeler, Brian E. Scheffler, Stuart Willis, Shawn R. Narum, Gary H. Thorgaard, Mohamed Salem, Yniv Palti   +9 more
wiley   +1 more source

Semaphorin Signaling in Cardiovascular Development

, 2015
Semaphorins were originally identified as neuronal guidance molecules mediating their attractive or repulsive signals by forming complexes with plexin and neuropilin receptors. Subsequent research has identified functions for semaphorin signaling in many
Singh, Manvendra K., Aghajanian, Haig, Epstein, Jonathan A.   +2 more
core   +1 more source

Effect of a High and Medium Intensity Interval Training Period with Liposomal Alpha-Lipoic Acid Supplementation on the Expression of Sema3A Protein in the Soleus Muscle of the Induced Diabetic Rats [PDF]

مجله دانشگاه علوم پزشکی گرگان, 2023
Background and Objective: Diabetes leads to impaired blood supply to the peripheral nerves. Sema3A (Semaphorin 3A) is a denervated protein that increases in response to hyperglycemia caused by diabetes.
Seyedeh Fatemeh Fatemi, Seyed Abdollah Hashemvarzi, Minoo Dadban Shahamat, Amin Farzaneh Hessari   +3 more
doaj  

An Outflow Tract Myocardium‐Specific Enhancer at the Sema3c Locus During Heart Development

Genes to Cells, Volume 31, Issue 4, July 2026.
Focusing on an OFT‐specific differentially accessible region, in the present study, we defined a distal OFT myocardial enhancer whose activity depends on GATA binding sites. This enhancer provides insight into the mechanisms underlying spatially restricted Sema3c expression involved in OFT development.
Yunce Wang, Yukihiro Harada, Tomoe Ueyama, Daiki Seya, Osamu Nakagawa, Teruhisa Kawamura   +5 more
wiley   +1 more source