Results 71 to 80 of about 14,138 (186)

Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb

Nature Communications, 2020
Reperfusion injury following myocardial ischemia is aggravated by inflammation and platelet–neutrophil complex formation. Here the authors show that semaphorin 7A binds to platelet GPIb, enhancing platelet–neutrophil interaction and increasing post ...
David Köhler, Tiago Granja, Julia Volz, Michael Koeppen, Harald F. Langer, Georg Hansmann, Ekaterina Legchenko, Tobias Geisler, Tamam Bakchoul, Claudia Eggstein, Helene A. Häberle, Bernhard Nieswandt, Peter Rosenberger   +12 more
doaj   +1 more source

Effects of Stromal Cell‐Derived Factor 1 on Osteoblast Activity During Orthodontic Tooth Movement

Clinical and Experimental Dental Research, Volume 12, Issue 4, August 2026.
ABSTRACT Objective This study aimed to clarify the relationship between stromal cell‑derived factor 1 (SDF‑1) and osteoblast‐related responses in periodontal ligament (PDL) during orthodontic tooth movement (OTM) after tooth extraction, based on the hypothesis that local inhibition of SDF‑1/C‑X‑C chemokine receptor type 4 (CXCR4) signaling with the ...
Yoshiyuki Hamada, Yuji Ishida, Albert Chun‐Shuo Huang, Kenta Hamahara, Duangtawan Rintanalert, Kai Li, Kasumi Hatano‐Sato, Jun Hosomichi, Risa Usumi‐Fujita, Takashi Ono   +9 more
wiley   +1 more source

Semaphorins in cardiovascular medicine

Trends in Molecular Medicine, 2014
During organogenesis, patterning is primarily achieved by the combined actions of morphogens. Among these, semaphorins represent a general system for establishing the appropriate wiring architecture of biological nets. Originally discovered as evolutionarily conserved steering molecules for developing axons, subsequent studies on semaphorins expanded ...
CORA', Davide, E. Astanina, E. Giraudo, F. Bussolino   +3 more
openaire   +3 more sources

Effect of a High and Medium Intensity Interval Training Period with Liposomal Alpha-Lipoic Acid Supplementation on the Expression of Sema3A Protein in the Soleus Muscle of the Induced Diabetic Rats [PDF]

مجله دانشگاه علوم پزشکی گرگان, 2023
Background and Objective: Diabetes leads to impaired blood supply to the peripheral nerves. Sema3A (Semaphorin 3A) is a denervated protein that increases in response to hyperglycemia caused by diabetes.
Seyedeh Fatemeh Fatemi, Seyed Abdollah Hashemvarzi, Minoo Dadban Shahamat, Amin Farzaneh Hessari   +3 more
doaj  

Neighboring Gulf Killifish (Fundulus grandis) Populations Differ in Their Plastic and Genetic Responses to Salinity Fluctuations

Ecology and Evolution, Volume 16, Issue 8, August 2026.
Coastal development can alter the salinity fluctuations experienced by tidal creek systems. Understanding how resident organisms, such as the Gulf killifish, respond to these changes is critical, as development along the coastline is projected to triple in the coming decades.
Antrelle D. Clark, Adam Hallaj, Christopher J. Anderson, Moisés A. Bernal   +3 more
wiley   +1 more source

RhoA is dispensable for axon guidance of sensory neurons in the mouse dorsal root ganglia

Frontiers in Molecular Neuroscience, 2012
RhoA, a member of Rho family small GTPases, has been shown to play important roles in axon guidance. However, it remains unknown whether RhoA is actually required for any axon guidance events in vivo in the mammalian nervous system.
Jennifer R Leslie, Fumiyasu eImai, Xuan eZhou, Richard A Lang, Yi eZheng, Yutaka eYoshida   +5 more
doaj   +1 more source

Plasma Membrane Remodeling During Microglial Activation: A Hypothesis Linking Microglial Shape and Lipid Droplet Formation

Glia, Volume 74, Issue 8, August 2026.
Microglial morphology changes in response to damage by Aβ and aging result in significant reductions in cell surface area. Transcriptomic analyses suggest that fatty acid synthesis and triacylglycerol formation drive redistribution of surface membrane into intracellular lipid droplets.
G. William Rebeck, Giorgi Shautidze, Jordy Sepulveda, Gracie S. Healey, Priyanka S. Narayan   +4 more
wiley   +1 more source

Keratan Sulfate: An Electroconductive Glycosaminoglycan at the Interface of Sensory Perception and Neural Signaling

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
Laboratory studies show KS has electroconductive properties with the ability to trap and transport protons in neurotransductive processes (Grotthuss proton shuttling). This maintains electrochemical gradients and fluxes at the neuronal cell surface in neural activation. Such processes are central to neuronal cell signaling and communication.
James Melrose
wiley   +1 more source

New Eukaryotic Semaphorins with Close Homology to Semaphorins of DNA Viruses

Genomics, 1998
Semaphorins were initially described as a family of repulsive guidance molecules in embryonal development. Their basic structure consists of an N-terminal signal sequence, the defining semaphorin domain ofapproximately 500 amino acids, an Ig-like domain,and a variable carboxy-terminus.
C, Lange, T, Liehr, M, Goen, E, Gebhart, B, Fleckenstein, A, Ensser   +5 more
openaire   +2 more sources

Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish

eLife
In a developing nervous system, axonal arbors often undergo complex rearrangements before neural circuits attain their final innervation topology. In the lateral line sensory system of the zebrafish, developing sensory axons reorganize their terminal ...
Agnik Dasgupta, Caleb C Reagor, Sang Peter Paik, Lauren M Snow, Adrian Jacobo, AJ Hudspeth   +5 more
doaj   +1 more source