Results 81 to 90 of about 14,138 (186)
Lymphatic Endothelial Cells in Health and Disease
MedComm, Volume 7, Issue 8, August 2026.Lymphatic endothelial cells (LECs) are dynamic regulators of tissue homeostasis and disease remodeling. In the healthy state, LECs coordinate interstitial fluid drainage, intestinal lipid transport, and immune trafficking and tolerance. Across disease settings, however, these same programs become maladaptively reprogrammed, contributing to barrier ...
Du Tang +5 more
wiley +1 more source
Molecular Genetics &Genomic Medicine, Volume 14, Issue 8, August 2026.A novel MC4R mutation (c.185A > G) was identified in a 10‐year‐old girl with severe obesity and hyperinsulinemia. Retrospective analysis of 64 pediatric cases revealed that mutation location influences BMI, modulated by underlying disease status, demonstrating that the genotype–phenotype relationship in MC4R‐associated obesity is clinically context ...
Xin Li +4 more
wiley +1 more source
eLife, 2017 The ellipsoid body (EB) in the Drosophila brain is a central complex (CX) substructure that harbors circumferentially laminated ring (R) neuron axons and mediates multifaceted sensory integration and motor coordination functions.
Xiaojun Xie +5 more
doaj +1 more source
The Journal of Physiology, Volume 604, Issue 15, Page 6281-6301, 1 August 2026.Abstract figure legend The β1‐adrenergic receptor is the predominant adrenergic subtype expressed on cardiac myocytes. Upon stimulation it activates downstream signalling pathways that increase the heart rate and cardiac output to meet metabolic demands.
Parham Diba +13 more
wiley +1 more source
Sema3E‐plexinD1 Axis Is a Modulator of Foxp3+ Regulatory T‐Cells in House Dust Mite Model of Asthma
The FASEB Journal, Volume 40, Issue 14, 31 July 2026.Airway epithelial‐derived Sema3E enhances both the number and proliferation of Foxp3+ regulatory T (Treg) cells in an acute model of asthma. Mechanistically, deletion of PlexinD1, the receptor for Sema3E, specifically in Foxp3+ cells was associated with a breakdown in immune regulation in this model.
Mojdeh Matloubi +6 more
wiley +1 more source
Semaphorin 3F and Netrin-1: The Novel Function as a Regulator of Tumor Microenvironment
Frontiers in Physiology, 2018 Axon guidance molecules play an important role in regulating proper neuronal networking during neuronal development. They also have non-neuronal properties, which include angiogenesis, inflammation, and tumor development. Semaphorin 3F (SEMA3F), a member
Hironao Nakayama +5 more
doaj +1 more source
Immunohistochemical distribution of Plexin A4 in the adult rat central nervous system
Frontiers in Neuroanatomy, 2010 PlexinA4 is the latest member to be identified of the plexin A subfamily, critical transducers of class 3 semaphorin signaling as co-receptors to neuropilins 1 and 2.
Claire-Anne Gutekunst +2 more
doaj +1 more source
Neural Regeneration ResearchThe nervous system processes a vast amount of information, performing computations that underlie perception, cognition, and behavior. During development, neuronal guidance genes, which encode extracellular cues, their receptors, and downstream signal ...
Junichi Yuasa-Kawada +8 more
doaj +1 more source
Frontiers in Neural Circuits, 2009 Fragile X syndrome, the most frequent form of familial mental retardation, is caused by mutation of the Fmr1 gene. Fmr1 encodes the Fragile X Mental Retardation Protein (FMRP), an mRNA binding protein regulating local, postsynaptic mRNA translation ...
Chanxia Li +3 more
doaj +1 more source