Results 81 to 90 of about 16,976 (234)

The MTRAP-Semaphorin-7A interaction is not influenced by glycans.

, 2012
(A) PNGase F treatment of Semaphorin-7A. Biotinylated Semaphorin-7A was incubated with PNGase F for 10, 30 or 60 minutes. Enzyme-treated and untreated Semaphorin-7A were resolved by SDS-PAGE under reducing conditions and detected by Western blotting ...
Susan Lea (121195), Cecile Crosnier (121193), Gavin J. Wright (121201), Leyla Y. Bustamante (121191), S. Josefin Bartholdson (121189), Steven Johnson (41082), Julian C. Rayner (121198)   +6 more
core   +1 more source

Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish

eLife
In a developing nervous system, axonal arbors often undergo complex rearrangements before neural circuits attain their final innervation topology. In the lateral line sensory system of the zebrafish, developing sensory axons reorganize their terminal ...
Agnik Dasgupta, Caleb C Reagor, Sang Peter Paik, Lauren M Snow, Adrian Jacobo, AJ Hudspeth   +5 more
doaj   +1 more source

RhoA is dispensable for axon guidance of sensory neurons in the mouse dorsal root ganglia

Frontiers in Molecular Neuroscience, 2012
RhoA, a member of Rho family small GTPases, has been shown to play important roles in axon guidance. However, it remains unknown whether RhoA is actually required for any axon guidance events in vivo in the mammalian nervous system.
Jennifer R Leslie, Fumiyasu eImai, Xuan eZhou, Richard A Lang, Yi eZheng, Yutaka eYoshida   +5 more
doaj   +1 more source

Synchronizing the Osteochondral Regeneration Process through Spatial Patterning of Stable and Hypertrophic Cartilage Organoids

Advanced Materials, Volume 38, Issue 33, 12 June 2026.
Zonated osteochondral assembloid implants are engineered through scaffold‐free spatial assembly of induced pluripotent stem cell (iPSC)‐derived chondrocyte organoids and periosteum‐derived osteogenic organoids. Implanted into full‐thickness rat osteochondral defects, they promote hyaline‐like cartilage repair, support subchondral bone formation with ...
Liuqi Peng, Isaak Decoene, Hanna Svitina, Ioannis Papantoniou   +3 more
wiley   +1 more source

Semaphorin 6C expression in innervated and denervated skeletal muscle

, 2008
Semaphorins are secreted or transmembrane proteins important for axonal guidance and for the structuring of neuronal systems. Semaphorin 6C, a transmembrane Semaphorin, has growth cone collapsing activity and is expressed in adult skeletal muscle. In the
Libelius, Rolf,, Svensson, Anna, Tågerud, Sven   +2 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 35, 24 June 2026.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Spatial transcriptomics reveals a new cluster of fibroblasts to promote the progression of lung adenocarcinoma

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
1. Spatial transcriptomics reveals two types of colocation patterns between lung cancer cells and fibroblasts in LUAD. SPP1+ TM4SF4+ epithelial cells and COL+ fibroblasts were co‐located in a highly malignant region, while SFTPC+ epithelial cells and DCN+ fibroblasts were in a low malignant region. 2.
Liyang Li, Xiaoxia Liu, Yifei Liu, Xuanqi Liu, Wanxin Duan, Yujia Jiang, Jian Chen, Tianxiang Chen, Gang Chen, Ao Chen, Duojiao Wu, Dongli Song, Yuanlin Song   +12 more
wiley   +1 more source

A 70 Amino Acid Region within the Semaphorin Domain Activates Specific Cellular Response of Semaphorin Family Members

, 1997
The semaphorin family contains secreted and transmembrane signaling proteins that function in the nervous, immune, and cardiovascular systems. Chick collapsin-1 is a repellent for specific growth cones. Two other secreted members of the semaphorin family,
Koppel, Adam M, Feiner, Leonard, Kobayashi, Hiroaki, Raper, Jonathan A   +3 more
core   +1 more source

Epigenetic Aging in Brain Tissue of the Self‐Fertilizing Vertebrate, Kryptolebias marmoratus

Ecology and Evolution, Volume 16, Issue 6, June 2026.
Using the self‐fertilizing vertebrate Kryptolebias marmoratus, we developed an epigenetic clock from brain tissue that predicts chronological age with high accuracy, demonstrating that DNA methylation changes consistently with age even in the near absence of genetic variation. The 40 age‐associated CpG sites identified map to genes with conserved roles
Justine Bélik, Frédéric Silvestre
wiley   +1 more source

Semaphorin-7A and MTRAP form an equimolar complex.

, 2012
(A) Size exclusion chromatography of purified His-tagged Semaphorin-7A and MTRAP, individually and as a complex. Semaphorin-7A (with Cd4-tag; top panel) and MTRAP (without Cd4-tag; middle panel) were analysed by SEC separately and as a complex (bottom ...
Susan Lea (121195), Cecile Crosnier (121193), Gavin J. Wright (121201), Leyla Y. Bustamante (121191), S. Josefin Bartholdson (121189), Steven Johnson (41082), Julian C. Rayner (121198)   +6 more
core   +1 more source