Proteostasis decline and endoplasmic reticulum stress in aging: Implications for cellular senescence and senescence-associated secretory phenotype regulation. [PDF]
Neural Regen ResPihán P, Ellerby LM, Hetz C.
europepmc +1 more source
Biomarkers to predict outcomes in diabetic foot ulcers
VIEW, EarlyView.Studies attempting to predict the healing outcome of diabetic foot ulcers (DFUs) have investigated various biological materials and recovered molecules that may aid in discriminating wounds that will heal and those that will not heal. This graphical abstract captures the commonly studied classes of biomarkers in the context of DFUs.
Julie Okiro +6 more
wiley +1 more source
Senescence-associated secretory phenotype in lung cancer: remodeling the tumor microenvironment for metastasis and immune suppression. [PDF]
Front OncolChen C, Chen J, Zhang Y, Zhang Q, Shi H.
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Progress in bone tissue engineering biomaterials: Development, challenges, and prospects
VIEW, EarlyView.Scheme 1 Application of biomaterials in immunomodulation during bone tissue engineering. Abstract Bone defect repair remains a major clinical challenge in orthopedics. Over 2 million cases caused by trauma, tumors, and other factors occur annually, with large‐scale defects posing a particular bottleneck due to limited self‐healing capacity.
Yuanbin Zhang +7 more
wiley +1 more source
The Journal of Dermatology, EarlyView.ABSTRACT Hard‐to‐heal wounds, such as diabetic foot ulcers and pressure injuries, pose major clinical challenges due to chronic inflammation and cellular senescence. Cellular senescence‐associated mechanisms, including stress‐responsive p53/p21 signaling and senescence‐associated secretory phenotype‐related inflammation, contribute to impaired wound ...
Daijiro Haba +6 more
wiley +1 more source
Cell enlargement modulated by GATA4 and YAP instructs the senescence-associated secretory phenotype. [PDF]
Nat CommunJoung J +12 more
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Microbiology and Immunology, EarlyView.ABSTRACT In this review, we introduce a promising strain for studying pathogenesis of nontuberculous mycobacterial pulmonary disease (NTM‐PD), Mycobacterium intracellulare M.i.198. M.i.198 was isolated from a patient with progressive Mycobacterium avium‐intracellulare complex pulmonary disease (MAC‐PD) in whom surgical operation was required to ...
Yoshitaka Tateishi +3 more
wiley +1 more source
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT Objective To explore trends of gestational diabetes (GDM) prevalence, as well as fasting, 1 h and 2 h post‐load glucose and its determinants in Hungary between 2010 and 2017. Design Cross‐sectional universal screening programme for GDM (3‐point 75 g OGTT at 24–28 weeks of gestation). Setting Tolna County (South‐Western Hungary). Population All
István Panykó +11 more
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Editorial: Immunosenescence in organ transplantation
Frontiers in TransplantationJasper Iske +5 more
doaj +1 more source
Profiling with senescence-associated secretory phenotype score identifies GDC-0879 as a small molecule sensitizing glioblastoma to anti-PD1. [PDF]
Cell Death DisLiu Y +5 more
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