Results 211 to 220 of about 51,520 (299)

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Loss of p62 Binding Allows TIF-IA Accumulation in Senescence, Which Promotes Phenotypic Changes to Nucleoli and the Senescence Associated Secretory Phenotype. [PDF]

Aging Cell
Thoms HC, Brant TS, Duckett K, Yang Y, Dong J, Wang H, Derby F, Akeke OF, Al-Alayeen F, Newell A, Manasterski P, Gopalakrishnan A, Mann D, Millar FR, Von Kriegsheim A, Acosta JC, Oakley F, Stark LA.   +17 more
europepmc   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, EarlyView.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma. [PDF]

Oncol Rep
Kitano Y, Miyashita T, Shimasaki T, Makino I, Endo Y, Yamamoto Y, Inaki N, Yagi S.   +7 more
europepmc   +1 more source

The Role of the Senescence-Associated Secretory Phenotype in Cardiovascular Disease Among the Elderly

Henry Sutanto, Deasy Fetarayani, Modigari Narendra, Sally Aman Nasution   +3 more
openalex   +2 more sources

Holistic bone developing microenvironment engineered apoptotic extracellular vesicles recapitulate multidimensional developmental signatures in adult and senile bone repair

Interdisciplinary Medicine, EarlyView.
The developing bone was identified as an M2a‐like macrophage driven immune microenvironment with multidimensional developmental signatures. hME‐ApoEVs were successfully fabricated via stimulating the M2a‐like developing microenvironment in vitro and confirmed its recapitulation of developmental features.
Xiaoran Yu, Jieyun Xu, Yuan Zhao, Xinyu Guo, Hongcheng Chen, Junlong Xue, Yong Ao, Linjun Zhang, Xiaomeng Gao, Xueli Mao, Songtao Shi, Zetao Chen   +11 more
wiley   +1 more source

NFATc1 facilitates hepatocellular carcinoma progression by regulating the senescence-associated secretory phenotype. [PDF]

Sci Rep
Chen Z, Huang L, Ding L, Zhang C, Li Y, Wang B, Shi J, Zhang J.   +7 more
europepmc   +1 more source

Features of senescence associated secretory phenotype (sasp) in gastrointestinal stromal tumors (GIsTs)

, 2014
Bulat R. Ramazanov, S. V. Boichuk, Albert A. Rizvanov   +2 more
openalex   +2 more sources

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Circulating senescence-associated secretory phenotype factors across the stages of type 1 diabetes in a cross-sectional cohort. [PDF]

Sci Rep
Préfontaine C, Pipella J, Heidinger I, Alcasid N, Thompson PJ.   +4 more
europepmc   +1 more source