Results 31 to 40 of about 62,581 (273)

NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype. [PDF]

Inflamm Res
Senescence is a cellular aging-related process triggered by different stresses and characterized by the secretion of various inflammatory factors referred to as senescence-associated secretory phenotype (SASP), some of which are produced by the NLRP3 ...
Muela-Zarzuela I, Suarez-Rivero JM, Gallardo-Orihuela A, Wang C, Izawa K, de Gregorio-Procopio M, Couillin I, Ryffel B, Kitaura J, Sanz A, von Zglinicki T, Mbalaviele G, Cordero MD.   +12 more
europepmc   +2 more sources

Role of cellular senescence and NOX4-mediated oxidative stress in systemic sclerosis pathogenesis. [PDF]

, 2015
Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by progressive fibrosis of skin and numerous internal organs and a severe fibroproliferative vasculopathy resulting frequently in severe disability and high mortality.
A Diazdeleon, A Dooley, A Erol, A Freund, A Gabrielli, A Gabrielli, A Gabrielli, A MacIntyre, A Salminen, A Servettaz, A Siani, A Sturrock, A Volpe, A Volpe, A Yoshizaki, AN Lyle, AZ Debbi, B Eckes, B Laleu, CB Harley, CD Bondi, CM Arlett, CM Stein, D Gvaramia, D Muñoz-Espin, D Muñoz-Espin, D Volonte, DE Furst, DF Murrell, E Rosato, E Savas, E Sikora, E Tourkina, E Tufvesson, ER Jarman, F Boin, F Gaggini, F Galdo Del, F Galdo Del, F Jiang, F Ogawa, F Ogawa, F Ogawa, F Tarhan, G Bai, G Simonini, GL Erre, GL Erre, H Sumimoto, H Xia, I Ben-Porath, I Cucoranu, I Montorfano, J Avouac, J Campisi, J El-Benna, J Goronzy, J Varga, JA Kim, JD Lambeth, JD Morrow, JF Passos, JF Passos, JH Chen, JL Barnes, JL Cracowski, JL Cracowski, JM Deursen van, JP Coppe, K Bedard, K Shimizu, KM Holmström, L Hayflick, L Hayflick, L Hecker, L Hecker, L Serrander, LL Song, M Böhm, M Chilosi, M Collado, M Elhai, M Geiszt, M Matucci-Cerinic, M Muller, M Schieber, M Storer, MD Mayes, MP Steele, MY Armanios, N Amara, N Duerrschmidt, N Manickam, N Sampson, O Babalola, P Cipriani, P Sambo, P Sambo, P Sambo, P Shivshankar, PS Tsou, Q Chen, QM Chen, R Salama, S Altenhöfer, S Bhattacharyya, S Parrinello, S Svegliati, Sergio A. Jimenez, SJ An, SK Parapuram, Sonsoles Piera-Velazquez, SR Datla, T Aoyama, T Finkel, T Kawahara, T Kuilman, T Ohtsuka, T Tchkonia, TK Kim, TR Katsumoto, VG Gorgoulis, VI Dumit, VJ Thannickal, WK Marut, WL Shen, X Duan, XM Wang, Y Allanore, Y Allanore, YH Paik   +130 more
core   +2 more sources

Proteomic Analysis of the Senescence-Associated Secretory Phenotype: GDF-15, IGFBP-2, and Cystatin-C Are Associated With Multiple Aging Traits

The journals of gerontology. Series A, Biological sciences and medical sciences, 2023
Cellular senescence, a hallmark of aging, results in a senescence-associated secretory phenotype (SASP) with an increased production of proinflammatory cytokines, growth factors, and proteases.
Daniel S. Evans, Danielle Young, Toshiko Tanaka, Nathan Basisty, S. Bandinelli, L. Ferrucci, Judith Campisi, Birgit Schilling   +7 more
semanticscholar   +1 more source

Radiation-induced senescence: therapeutic opportunities

Radiation Oncology, 2023
The limitation of cancer radiotherapy does not derive from an inability to ablate tumor, but rather to do so without excessively damaging critical tissues and organs and adversely affecting patient’s quality of life.
Jae Ho Kim, Stephen L. Brown, Marcia N. Gordon   +2 more
doaj   +1 more source

Disuse‐induced muscle fibrosis, cellular senescence, and senescence‐associated secretory phenotype in older adults are alleviated during re‐ambulation with metformin pre‐treatment

Aging Cell, 2023
Muscle inflammation and fibrosis underlie disuse‐related complications and may contribute to impaired muscle recovery in aging. Cellular senescence is an emerging link between inflammation, extracellular matrix (ECM) remodeling and poor muscle recovery ...
Jonathan J Petrocelli, Alec I. McKenzie, N. M. de Hart, P. Reidy, Z. Mahmassani, A. R. Keeble, Katie Kaput, Matthew P Wahl, M. Rondina, R. Marcus, C. Welt, W. Holland, K. Funai, C. Fry, M. Drummond   +14 more
semanticscholar   +1 more source

RUNX-mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins [PDF]

, 2018
RUNX gene over-expression inhibits growth of primary cells but transforms cells with tumor suppressor defects, consistent with reported associations with tumor progression.
Anderson, Gail, Bell, Margaret, Borland, Gillian, Cameron, Ewan, Gilroy, Kathryn, Hassanudin, Siti Ayuni, Hay, Jodie, Kilbey, Anna, Mackay, Nancy, McDonald, Alma, Neil, James C.   +10 more
core   +1 more source

The light and shadow of senescence and inflammation in cardiovascular pathology and regenerative medicine [PDF]

, 2017
Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised ...
Cavarretta, Elena, Dal Sasso, Eleonora, Forte, Maurizio, Frati, Giacomo, Gerosa, Gino, Iop, Laura, Palmerio, Silvia, Peruzzi, Mariangela, Schirone, Leonardo, Sciarretta, Sebastiano   +9 more
core   +4 more sources

Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination.

Cell Reports, 2021
In the tumor microenvironment, senescent non-malignant cells, including cancer-associated fibroblasts (CAFs), exhibit a secretory profile under stress conditions; this senescence-associated secretory phenotype (SASP) leads to cancer progression and ...
Tadahito Yasuda, Mayu Koiwa, Atsuko Yonemura, K. Miyake, R. Kariya, Sho Kubota, Takako Yokomizo-Nakano, Noriko Yasuda-Yoshihara, Tomoyuki Uchihara, R. Itoyama, L. Bu, Lingfeng Fu, K. Arima, Daisuke Izumi, S. Iwagami, K. Eto, M. Iwatsuki, Y. Baba, N. Yoshida, H. Ohguchi, S. Okada, K. Matsusaki, G. Sashida, Akiko Takahashi, P. Tan, H. Baba, T. Ishimoto   +26 more
semanticscholar   +1 more source

Redox control of senescence and age-related disease

Redox Biology, 2017
The signaling networks that drive the aging process, associated functional deterioration, and pathologies has captured the scientific community's attention for decades.
Akshaya Chandrasekaran, Maria del Pilar Sosa Idelchik, J. Andrés Melendez   +2 more
doaj   +1 more source

Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression.

Molecules and Cells, 2021
Cellular senescence is a state of stable proliferative arrest triggered by damaging signals. Senescent cells persist during aging and promote age-related pathologies via the pro-inflammatory senescence-associated secretory phenotype (SASP), whose ...
T. van Vliet, M. Varela-Eirín, Boshi Wang, M. Borghesan, S. Brandenburg, R. Franzin, K. Evangelou, M. Seelen, V. Gorgoulis, M. Demaria   +9 more
semanticscholar   +1 more source