Results 1 to 10 of about 30,050 (236)

Measuring the Senescence-Associated Secretory Phenotype [PDF]

Biomedicines
Cellular senescence is a fundamental hallmark of aging, contributing to tissue dysfunction and chronic disease through the senescence-associated secretory phenotype (SASP).
Achilleas Karras, Georgios Lioulios, Konstantia Kantartzi, Asimina Fylaktou, Stylianos Panagoutsos, Maria Stangou   +5 more
doaj   +4 more sources

Cell senescence, the senescence-associated secretory phenotype, and cancers. [PDF]

PLoS Biology, 2023
Cellular senescence is a cell fate caused by multiple stresses. A 2008 article in PLOS Biology reported a senescence-associated secretory phenotype that can promote inflammation and cancer, eventually enabling the development of senolytic drugs.
Larissa G P Langhi Prata, Tamar Tchkonia, James L Kirkland   +2 more
doaj   +4 more sources

Recent advances in senescence-associated secretory phenotype and osteoporosis [PDF]

Heliyon
The worldwide elderly population is on the rise, and aging is a major osteoporosis risk factor. Senescent cells accumulation can have a detrimental effect the body as we age.
Haonan Fan, Zhi Qiao, Jitian Li, Guowei Shang, Chunfeng Shang, Songfeng Chen, Zikuan Leng, Huifang Su, Hongwei Kou, Hongjian Liu   +9 more
doaj   +4 more sources

Mechanisms and therapeutic strategies for senescence-associated secretory phenotype in the intervertebral disc degeneration microenvironment [PDF]

Journal of Orthopaedic Translation
As a permanent state of cell cycle arrest, cellular senescence has become an important factor in aging and age-related diseases. As a central regulator of physiology and pathology associated with cellular senescence, the senescence associated secretory ...
Yang Liu, Yiming Dou, Xun Sun, Qiang Yang   +3 more
doaj   +2 more sources

Analysis of molecular subtypes and prognostic signature of senescence-associated secretory phenotype in pancreatic cancer [PDF]

PeerJ
Background Pancreatic cancer (PC) exhibits an extremely poor prognosis due to its high heterogeneity. The senescence-associated secretory phenotype (SASP), a distinct secretory profile displayed by senescent cells, has been increasingly studied. However,
Yuewen Kuang, Mingkun Jia, Yuming Zhu, Zhiyong Xiang   +3 more
doaj   +3 more sources

Reduction in Lens Epithelial Cell Senescence Burden through Dasatinib Plus Quercetin or Rapamycin Alleviates D-Galactose-Induced Cataract Progression

Journal of Functional Biomaterials, 2022
Senescent cells accumulate in aged organisms and promote the progression of age-related diseases including cataracts. Therefore, we aimed to study the therapeutic effects of senescence-targeting drugs on cataracts.
Yinhao Wang, Yulin Tseng, Keyu Chen, Xinglin Wang, Zebin Mao, Xuemin Li   +5 more
doaj   +1 more source

Growth differentiation factor‐15 is associated with age‐related monocyte dysfunction

Aging Medicine, 2021
Objective Age‐associated decreases in immune functions are precipitated by a variety of mechanisms and affect nearly every immune cell subset. In myeloid cells, aging reduces numbers of phagocytes and impairs their functional abilities, including antigen
Brandt D. Pence, Johnathan R. Yarbro, Russell S. Emmons   +2 more
doaj   +1 more source

Altered regulation of mesenchymal cell senescence in adipose tissue promotes pathological changes associated with diabetic wound healing

Communications Biology, 2022
Type-2 diabetic adipose tissue impairs transient senescence during wound healing with expression of different components of the senescence-associated secretory phenotype (SASP), and this is associated with deteriorated wound healing.
Arisa Kita, Yuki Saito, Norihiro Miura, Maki Miyajima, Sena Yamamoto, Tsukasa Sato, Takatoshi Yotsuyanagi, Mineko Fujimiya, Takako S. Chikenji   +8 more
doaj   +1 more source

Overcoming the senescence‐associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer

Molecular Oncology, 2021
Senescence is a cellular state in which cells undergo persistent cell cycle arrest in response to nonlethal stress. In the treatment of cancer, senescence induction is a potent method of suppressing tumour cell proliferation.
Cecilia R. Chambers, Shona Ritchie, Brooke A. Pereira, Paul Timpson   +3 more
doaj   +1 more source

Senescent cells and macrophages: key players for regeneration? [PDF]

Open Biology, 2020
Over the last decade, our understanding of the physiological role of senescent cells has drastically evolved, from merely indicators of cellular stress and ageing to having a central role in regeneration and repair.
Sonia S. Elder, Elaine Emmerson
doaj   +1 more source