Results 11 to 20 of about 30,050 (236)

Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype [PDF]

Journal of Proteome Research, 2020
Primary diploid cells exit the cell cycle in response to exogenous stress or oncogene activation through a process known as cellular senescence. This cell-autonomous tumor-suppressive mechanism is also a major mechanism operative in organismal aging. To date, temporal aspects of senescence remain understudied.
Peter F. Doubleday, Luca Fornelli, Neil L. Kelleher   +2 more
openaire   +2 more sources

Acute ischemic stroke triggers a cellular senescence-associated secretory phenotype [PDF]

Scientific Reports, 2021
Abstract Senescent cells are capable of expressing a myriad of inflammatory cytokines and this pro-inflammatory phenomenon is known as senescence-associated secretory phenotype (SASP). The contribution of this phenomenon in brain ischemia was scarce.
Torres Querol, Coral, Torres, Pascual, Vidal, Noemí, Portero-Otin, Manuel, Arque, Gloria, Purroy, Francisco   +5 more
openaire   +4 more sources

MLL1 is essential for the senescence-associated secretory phenotype [PDF]

Genes & Development, 2016
Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominently includes an array of cytokines known as the senescence-associated secretory phenotype (SASP ...
Capell, Brian C., Drake, Adam M., Zhu, Jiajun, Shah, Parisha P., Dou, Zhixun, Dorsey, Jean, Simola, Daniel F., Donahue, Greg, Sammons, Morgan, Rai, Taranjit, Natale, Christopher, Ridky, Todd W., Adams, Peter D., Berger, Shelley L.   +13 more
openaire   +3 more sources

Suppression of p16 alleviates the senescence-associated secretory phenotype

Aging, 2021
Oncogene-induced senescence (OIS) is characterized by increased expression of the cell cycle inhibitor p16, leading to a hallmark cell cycle arrest. Suppression of p16 in this context drives proliferation, senescence bypass, and contributes to tumorigenesis.
Buj, Raquel, Leon, Kelly E., Anguelov, Marlyn A., Aird, Katherine M.   +3 more
openaire   +2 more sources

The Paradoxical Role of Cellular Senescence in Cancer

Frontiers in Cell and Developmental Biology, 2021
Cellular senescence occurs in proliferating cells as a consequence of various triggers including telomere shortening, DNA damage, and inappropriate expression of oncogenes.
Jing Yang, Jing Yang, Mengmeng Liu, Mengmeng Liu, Dongchun Hong, Dongchun Hong, Musheng Zeng, Xing Zhang   +7 more
doaj   +1 more source

NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype. [PDF]

Inflamm Res
Abstract Background Senescence is a cellular aging-related process triggered by different stresses and characterized by the secretion of various inflammatory factors referred to as senescence-associated secretory phenotype (SASP), some of which are produced by the NLRP3 inflammasome.
Muela-Zarzuela I, Suarez-Rivero JM, Gallardo-Orihuela A, Wang C, Izawa K, de Gregorio-Procopio M, Couillin I, Ryffel B, Kitaura J, Sanz A, von Zglinicki T, Mbalaviele G, Cordero MD.   +12 more
europepmc   +3 more sources

The Role of Senescence-Associated Secretory Phenotype in Bone Loss [PDF]

Frontiers in Cell and Developmental Biology, 2022
As the population of most nations have a large proportion of older individuals, there is an increase in the prevalence of osteoporosis. Consequently, scientists have focused their attention on the pathogenic mechanisms of osteoporosis. Owing to an increase in studies on cellular senescence in recent years, research has begun to focus on the function of
Runjiu Zhu, Runjiu Zhu, Haoyang Wan, Haoyang Wan, Hong Yang, Mingrui Song, Mingrui Song, Yu Chai, Yu Chai, Bin Yu, Bin Yu   +10 more
openaire   +3 more sources

Senescence: Definition, mechanisms of occurence and detection in tissues [PDF]

Medicinski Podmladak
A cellular senescence represents a state, which is defined as a stable blockage of the cellular cycle in the G1 phase, as an answer to multiple triggers and their qualitative and quantitative characteristics. Alongside the blockage of the cellular cycle,
Mijajlović Vladimir, de Luka Silvio, Manojlović-Gačić Emilija   +2 more
doaj   +1 more source

Late Depression and Senescence-Associated Secretory Phenotype (SASP) [PDF]

Eur Psychiatry
IntroductionNeurobiological mechanisms of late depression include abnormal regulation and interaction of multiple biological processes, as well as abnormalities of brain structures and organs.Objectivesliterature analysisMethodsgeneral scientific methodResultsThe results of the study show that the SASP index as an integral indicator of changes in ...
Sidenkova A.
europepmc   +2 more sources

NF90 coordinately represses the senescence-associated secretory phenotype

Aging, 2012
A hallmark trait of cellular senescence is the acquisition of a senescence-associated secretory phenotype (SASP). SASP factors include cytokines and their receptors (IL-6, IL-8, osteoprotegerin, GM-CSF), chemokines and their ligands (MCP-1, HCC4), and oncogenes (Gro1 and Gro2), many of them encoded by mRNAs whose stability and translation are tightly ...
Kumiko, Tominaga-Yamanaka, Kotb, Abdelmohsen, Jennifer L, Martindale, Xiaoling, Yang, Dennis D, Taub, Myriam, Gorospe   +5 more
openaire   +2 more sources