Results 21 to 30 of about 30,050 (236)
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
Frontiers in Cell and Developmental Biology, 2021 Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in response to various intrinsic and extrinsic stimuli, as well as developmental signals.
Ruchi Kumari, Parmjit Jat
doaj +1 more source
Engineering mammalian cells to seek senescence-associated secretory phenotypes [PDF]
Journal of Cell Science, 2017 ABSTRACT Since the removal of senescent cells in model organisms has been linked to rejuvenation and increased lifespan, senotherapies have emerged to target senescent cells for death. In particular, interleukin-6 (IL6) is a prominent senescence-associated secretory phenotype (SASP) and, thus, seeking IL6 could potentially localize ...
Anam Qudrat, Janice Wong, Kevin Truong
openaire +2 more sources
G3BP1 controls the senescence-associated secretome and its impact on cancer progression
Nature Communications, 2020 The mechanisms that control the deleterious behaviour of senescent cells is unclear. Here, the authors show that G3BP1 is required for the induction of the senescence-associated secretory phenotype (SASP), without affecting senescence, and that SASP ...
Amr Omer +6 more
doaj +1 more source
Radiation-induced senescence: therapeutic opportunities
Radiation Oncology, 2023 The limitation of cancer radiotherapy does not derive from an inability to ablate tumor, but rather to do so without excessively damaging critical tissues and organs and adversely affecting patient’s quality of life.
Jae Ho Kim +2 more
doaj +1 more source
Antioxidants, 2023 Inflammaging is a potential risk factor for cardiovascular diseases. It results in the development of thrombosis and atherosclerosis. The accumulation of senescent cells in vessels causes vascular inflammaging and contributes to plaque formation and ...
Huakang Zhou +6 more
doaj +1 more source
Redox control of senescence and age-related disease
Redox Biology, 2017 The signaling networks that drive the aging process, associated functional deterioration, and pathologies has captured the scientific community's attention for decades.
Akshaya Chandrasekaran +2 more
doaj +1 more source
Effect of menopausal hormone therapy on proteins associated with senescence and inflammation
Physiological Reports, 2020 Background Estrogen may inhibit cell senescence that contributes to age‐related disorders. This study determined the effects of menopausal hormone treatments on circulating levels of markers of cell senescence.
Laura Faubion +7 more
doaj +1 more source
Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype [PDF]
Scientific Reports, 2018 AbstractProcesses that have been linked to aging and cancer include an inflammatory milieu driven by senescent cells. Senescent cells lose the ability to divide, essentially irreversibly, and secrete numerous proteases, cytokines and growth factors, termed the senescence-associated secretory phenotype (SASP).
Wiley, Christopher D +9 more
openaire +4 more sources
The Senescence-Associated Secretory Phenotype Promotes Benign Prostatic Hyperplasia
The American Journal of Pathology, 2014 Benign prostatic hyperplasia (BPH) is characterized by increased tissue mass in the transition zone of the prostate, which leads to obstruction of urine outflow and considerable morbidity in a majority of older men. Senescent cells accumulate in human tissues, including the prostate, with increasing age.
Vital, Paz +3 more
openaire +2 more sources
Mettl14-driven senescence-associated secretory phenotype facilitates somatic cell reprogramming
Stem Cell Reports, 2022 The METTL3-METTL14 complex, the "writer" of N6-methyladenosine (m6A), plays an important role in many biological processes. Previous studies have shown that Mettl3 overexpression can increase the level of m6A and promote somatic cell reprogramming. Here, we demonstrate that Mettl14, another component of the methyltransferase complex, can significantly ...
Chenxiang Xi +18 more
openaire +2 more sources