Results 31 to 40 of about 30,050 (236)

Primary high-grade serous ovarian cancer cells are sensitive to senescence induced by carboplatin and paclitaxel in vitro

Cellular & Molecular Biology Letters, 2021
Background Various types of normal and cancer cells undergo senescence in response to carboplatin and paclitaxel, which are considered the gold standard treatments in ovarian cancer management.
Paweł Uruski, Agnieszka Sepetowska, Corinna Konieczna, Martyna Pakuła, Michał Wyrwa, Akylbek Tussupkaliyev, Andrzej Tykarski, Justyna Mikuła-Pietrasik, Krzysztof Książek   +8 more
doaj   +1 more source

QS2: Aberrant Breast Adipose Stromal Cell Biology In Women At High Risk For Developing Breast Cancer

Plastic and Reconstructive Surgery, Global Open, 2021
Purpose: Our laboratory studies contributions of breast adipose stromal cells (bASCs) to breast cancer initiation and progression. To date, most studies of ASC biology have focused on abdominal ASCs.
Mahsa Taskindoust, BS, Tingjun Xie, MD, Valery Nelson, MS, Bryanna Stukes, MHS, Scott Hollenbeck, MD, Robin Bachelder, PhD   +5 more
doaj   +1 more source

HMGB2 holds the key to the senescence-associated secretory phenotype [PDF]

Journal of Cell Biology, 2016
The senescence-associated secretory phenotype (SASP) is a hallmark of senescence with an important physiological impact, but how it is established is unclear. In this issue, Aird et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201608026) describe how chromatin-bound HMGB2 fine tunes SASP expression by avoiding heterochromatin spreading.
Guerrero a, Gil, J
openaire   +4 more sources

Pro-cancerogenic effects of spontaneous and drug-induced senescence of ovarian cancer cells in vitro and in vivo: a comparative analysis

Journal of Ovarian Research, 2022
Background Clinical outcomes of cancer cell senescence are still elusive. Here, we reveal and compare pro-cancerous activity of spontaneously and drug-inducible senescent ovarian cancer cells.
Szymon Rutecki, Paulina Szulc, Martyna Pakuła, Paweł Uruski, Artur Radziemski, Eryk Naumowicz, Rafał Moszyński, Andrzej Tykarski, Justyna Mikuła-Pietrasik, Krzysztof Książek   +9 more
doaj   +1 more source

Glucocorticoids suppress selected components of the senescence‐associated secretory phenotype [PDF]

Aging Cell, 2012
SummaryCellular senescence suppresses cancer by arresting the proliferation of cells at risk for malignant transformation. Recently, senescent cells were shown to secrete numerous cytokines, growth factors, and proteases that can alter the tissue microenvironment and may promote age‐related pathology.
Remi-Martin, Laberge, Lili, Zhou, Melissa R, Sarantos, Francis, Rodier, Adam, Freund, Peter L J, de Keizer, Su, Liu, Marco, Demaria, Yu-Sheng, Cong, Pankaj, Kapahi, Pierre-Yves, Desprez, Robert E, Hughes, Judith, Campisi   +12 more
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Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype

Nature Metabolism, 2023
Abstract Fibrogenesis is part of a normal protective response to tissue injury that can become irreversible and progressive, leading to fatal diseases. Senescent cells are a main driver of fibrotic diseases through their secretome, known as senescence-associated secretory phenotype (SASP). Here, we report that cellular senescence, and
Mate Maus, Vanessa López-Polo, Lidia Mateo, Miguel Lafarga, Mònica Aguilera, Eugenia De Lama, Kathleen Meyer, Anna Sola, Cecilia Lopez-Martinez, Ines López-Alonso, Marc Guasch-Piqueras, Fernanda Hernandez-Gonzalez, Selim Chaib, Miguel Rovira, Mayka Sanchez, Rosa Faner, Alvar Agusti, Rodrigo Diéguez-Hurtado, Sagrario Ortega, Anna Manonelles, Stefan Engelhardt, Freddy Monteiro, Camille Stephan-Otto Attolini, Neus Prats, Guillermo Albaiceta, Josep M. Cruzado, Manuel Serrano   +26 more
openaire   +5 more sources

Senescence and SASP Are Potential Therapeutic Targets for Ischemic Stroke

Pharmaceuticals
Aging is a known co-morbidity of ischemic stroke with its risk and severity increasing every year past 55+. While many of the current stroke therapies have shown success in reducing mortality, post-stroke morbidity has not seen the same substantial ...
Blake Ouvrier, Saifudeen Ismael, Gregory Jaye Bix   +2 more
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Isolation methodology is essential to the evaluation of the extracellular vesicle component of the senescence‐associated secretory phenotype

Journal of Extracellular Vesicles, 2021
A hallmark of senescence is the acquisition of an enhanced secretome comprising inflammatory mediators and tissue remodelling agents – the senescence‐associated secretory phenotype (SASP).
Ryan Wallis, Natasa Josipovic, Hannah Mizen, Arturo Robles‐Tenorio, Eleanor J. Tyler, Argyris Papantonis, Cleo L. Bishop   +6 more
doaj   +1 more source

A Model for p38MAPK-Induced Astrocyte Senescence.

PLoS ONE, 2015
Experimental evidence indicates that aging leads to accumulation of senescent cells in tissues and they develop a secretory phenotype (also known as SASP, for senescence-associated secretory phenotype) that can contribute to chronic inflammation and ...
José C M Mombach, Bruno Vendrusculo, Cristhian A Bugs   +2 more
doaj   +1 more source

Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy

Frontiers in Oncology, 2018
In addition to promoting various forms of cell death, most conventional anti-tumor therapies also promote senescence. There is now extensive evidence that therapy-induced senescence (TIS) might be transient, raising the concern that TIS could represent ...
Tareq Saleh, Tareq Saleh, Liliya Tyutynuk-Massey, Liliya Tyutynuk-Massey, Emmanuel K. Cudjoe, Michael O. Idowu, Joseph W. Landry, Joseph W. Landry, David A. Gewirtz, David A. Gewirtz   +9 more
doaj   +1 more source