Results 1 to 10 of about 6,287 (219)
Senolytics and senostatics as adjuvant tumour therapy [PDF]
EBioMedicine, 2019 Cell senescence is a driver of ageing, frailty, age-associated disease and functional decline. In oncology, tumour cell senescence may contribute to the effect of adjuvant therapies, as it blocks tumour growth. However, this is frequently incomplete, and
Susan Short +3 more
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The Role of Senolytics in Osteoporosis [PDF]
BiomoleculesCellular senescence is a fundamental contributor to numerous dysfunctions and degenerative diseases, including osteoporosis. In genetically modified and preclinical animal models, therapeutic strategies targeting persistent senescent cells have been ...
Erman Chen +3 more
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Targeting Cellular Senescence to Enhance Human Endometrial Stromal Cell Decidualization and Inhibit Their Migration [PDF]
BiomoleculesCellular senescence leads to stable cell cycle arrest and an inflammatory senescence-associated secretory phenotype that varies with stressor and cell type. To mitigate these effects and improve health, senotherapeutics (e.g., senolytics and senomorphics)
Julia Delenko +12 more
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Targeting Senescence: A Review of Senolytics and Senomorphics in Anti-Aging Interventions [PDF]
BiomoleculesCellular senescence is a fundamental mechanism in aging, marked by irreversible growth arrest and diverse functional changes, including, but not limited to, the development of a senescence-associated secretory phenotype (SASP). While transient senescence
Timur Saliev, Prim B. Singh
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Frontiers in Cell and Developmental Biology, 2022 Senolytics are a class of drugs that selectively eliminate senescent cells and ameliorate senescence-associated disease. Studies have demonstrated the accumulation of senescent disc cells and the production of senescence-associated secretory phenotype ...
Bolin Chen +9 more
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The costs and benefits of senotherapeutics for human health
The Lancet. Healthy Longevity, 2022 Summary: Cellular senescence is a major contributor to age-related diseases in humans; however, it also has a beneficial role in physiological and pathological processes, including wound healing, host immunity, and tumour suppression. Reducing the burden
Marco Raffaele, PhD +1 more
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Impact of senolytic treatment on immunity, aging, and disease
Frontiers in Aging, 2023 Cellular senescence has been implicated in the pathophysiology of many age-related diseases. However, it also plays an important protective role in the context of tumor suppression and wound healing.
Erica C. Lorenzo +4 more
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Senolytics as drugs or fashionable dietary supplements [PDF]
Farmacja Polska, 2021 : Senolytics are a group of medicinal substances that selectively remove the so-called aging cells. The available theories indicate that these cells are resistant to apoptosis and accumulate at the causal sites of many chronic disorders and diseases, are
Małgorzata Starek +2 more
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A versatile method for the identification of senolytic compounds
Cell Stress, 2023 The increased burden of senescent cells is as a well-established hallmark of aging and age-related diseases. This finding sparked significant interest in the identification of molecules capable of selectively eliminating senescent cells, so-called ...
Chiara Annunziata +8 more
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COVID-19 and chronological aging : senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection? [PDF]
, 2020 COVID-19, also known as SARS-CoV-2, is a new emerging zoonotic corona virus of the SARS (Severe Acute Respiratory Syndrome) and the MERS (Middle East Respiratory Syndrome) family.
Auwerx +30 more
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