Results 111 to 120 of about 6,287 (219)

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Exploring the Intersections of Immunosenescence and Cellular Senescence in Health and Disease [PDF]

This thesis provides a comprehensive investigation into the role of cellular senescence in immune cells, focusing on macrophages and microglia in aging, diseases, and therapeutic responses, as well as the immune landscape during COVID-19.
Melo, Letícya
core   +1 more source

Dual‐Target ROS‐Driven Spatiotemporal Senolysis for Vascular Repair and Immune Microenvironment Reprogramming in the Treatment of Ocular Fundus Neovascularization

Advanced Science, Volume 13, Issue 16, 18 March 2026.
We developed a senolytic approach using procyanidin C1 (PCC1)‐loaded platform, a clinically established and safe hyaluronic acid‐based scaffold, to selectively eliminate senescent endothelial and microglial cells. This dual‐targeting strategy significantly suppresses pathological neovascularization and promotes vascular repair, presenting a safe and ...
Yali Zhou, Tianxing Chen, Peiyu Liu, Kangjia Lv, Yifan Wang, Xiaoqian Wang, Junwei Fang, Chong Chen, Zhaoyang Wang, Fang Wei, Xun Xu   +10 more
wiley   +1 more source

Targeting senescent cells in translational medicine. [PDF]

, 2019
Organismal ageing is a complex process driving progressive impairment of functionality and regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest occurring in response to damage and stress and is considered a ...
Doherty, Gary J, González-Gualda, Estela, Muñoz-Espín, Daniel, Paez-Ribes, Marta   +3 more
core   +2 more sources

Dasatinib and Quercetin Combination Increased Kidney Damage in Acute Folic Acid-Induced Experimental Nephropathy

Pharmaceuticals
Background/Objectives: Acute kidney injury (AKI) remains an unsolved medical problem due to the lack of effective treatments, high mortality, and increased susceptibility to progression to chronic kidney disease (CKD), especially in the elderly. Cellular
Antonio Battaglia-Vieni, Vanessa Marchant, Lucia Tejedor-Santamaria, Cristina García-Caballero, Elena Flores-Salguero, María Piedad Ruiz-Torres, Sandra Rayego-Mateos, Ana Belen Sanz, Alberto Ortiz, Marta Ruiz-Ortega   +9 more
doaj   +1 more source

Nanomotor‐Driven Extracellular Vesicles With Effective Tissue Penetration for Targeted Therapy of Primary Ovarian Insufficiency

Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
ABSTRACT Stem cells and their derived extracellular vesicles (EVs) offer hope for functional reconstruction and fertility in premature ovarian insufficiency (POI) caused by gonadotoxic drugs. However, the clinical application of EVs is impeded by their instability, limited tissue penetration, and lack of targeted delivery to ovarian injury sites. Here,
Yaoqin Mu, Jiachen Wu, Mingwei Lv, Xinyi Zhang, Yinhua Song, Jihui Ai, Ding Ma, Kezhen Li   +7 more
wiley   +1 more source

Cholesterol accumulation promotes photoreceptor senescence and retinal degeneration [PDF]

PURPOSE: Dysregulated cholesterol metabolism is critical in the pathogenesis of AMD. Cellular senescence contributes to the development of numerous age-associated diseases.
Apte, Rajendra S, Colasanti, Jason, Lee, Tae Jun, Lin, Joseph B, Pfeifer, Charles W, Santeford, Andrea, Sohn, Brian S, Terao, Ryo, Yamaguchi, Shinobu, Yamamoto, Taku, Yoshida, Mitsukuni   +10 more
core   +2 more sources

Translational Pathways for Smart and Bioactive Dental Biomaterials: Biocompatibility Standards, Sterilisation, Sustainability and Regulation

MedComm – Biomaterials and Applications, Volume 5, Issue 1, March 2026.
Smart and bioactive dental biomaterials can do more than replace tissue, but getting them into the clinic requires more than promising lab results. This review brings together practical requirements for translation, covering ISO‐based biocompatibility planning, low‐temperature sterilisation for sensitive materials, life‐cycle assessment for ...
Katarzyna Chojnacka, Marcin Mikulewicz
wiley   +1 more source

Senolytic treatment for low back pain

Science Advances
Senescent cells (SnCs) accumulate because of aging and external cellular stress throughout the body. They adopt a senescence-associated secretory phenotype (SASP) and release inflammatory and degenerative factors that actively contribute to age-related diseases, such as low back pain (LBP). The senolytics, o
Mannarino, Matthew, Cherif, Hosni, Ghazizadeh, Saber, Martinez, Oliver Wu, Sheng, Kai, Cousineau, Elsa, Lee, Seunghwan, Millecamps, Magali, Gao, Chan, Gilbert, Alice, Peirs, Cedric, Naeini, Reza Sharif, Ouellet, Jean, S. Stone, Laura, Haglund, Lisbet   +14 more
openaire   +3 more sources

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source