Results 121 to 130 of about 6,287 (219)

Examining the effects of quercetin on phenotypic characteristics of human mesenchymal stem cells [PDF]

Introduction A significant obstacle to mesenchymal stem cell (MSC) potency and therapeutic utility is in vitro senescence, an irreversible cessation of replication associated with age-related complications.
Needy, Thomas M
core   +3 more sources

The effect of dihydroquercetin therapy on clinical status and the burden of senescent cells in elderly patients with chronic heart failure: rationale and study design

Российский журнал гериатрической медицины
RELEVANCE. Chronic heart failure (CHF) is an age-related disease affecting approximately 63 million people worldwide. In Russia, the prevalence of CHF has increased from 6.1 % to 8.2 % over the past 20 years, with most experts attributing this growth to ...
I. Sh. Daudov, A. G. Plisyuk, R. A. Abramovich, O. G. Potanina, A. G. Klementeva, Zh. A. Akopyan, A. Yu. Efimenko, Ya. A. Orlova   +7 more
doaj   +1 more source

Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Cellular senescence shapes tumor progression through both antitumor and protumor mechanisms. Senescence triggered by telomere shortening restricts malignant transformation and limits tumor cell proliferation, while the senescence‐associated secretory phenotype (SASP) secretion enhances antitumor immunity by activating cytotoxic T cells.
Huajie Mao, Wanning Liu, Yuanyuan Su, Yuxuan Ma, Xiaodi Zhao, Yuanyuan Lu   +5 more
wiley   +1 more source

Dasatinib and Quercetin alleviate type 2 diabetic osteoporosis by regulating serum metabolite and gut microbiome

Frontiers in Microbiology
Type 2 diabetic osteoporosis (T2DOP) is a complex metabolic bone disorder characterized by reduced bone density and increased risk of osteoporosis in patients with type 2 diabetes mellitus. The etiology of T2DOP is multifactorial, involving hyperglycemia,
Junzheng Yang, Junzheng Yang, Junzheng Yang, Junzheng Yang, Hua Zhang, Zhuoxu Gu, Zhuoxu Gu, Zhuoxu Gu, Guanghui Zhou, Guanghui Zhou, Guanghui Zhou, Guihong Liang, Guihong Liang, Guihong Liang, Lingfeng Zeng, Lingfeng Zeng, Lingfeng Zeng, Jinlong Zhao, Jinlong Zhao, Jinlong Zhao, Weiyi Yang, Weiyi Yang, Weiyi Yang, Jun Liu, Jun Liu, Jun Liu, Jun Liu, Jun Liu, Jun Liu, Jianke Pan, Jianke Pan, Jianke Pan   +31 more
doaj   +1 more source

Senescent Mesenchymal Stromal Cells Differentially Alter Adipogenesis in Adipose Tissue, Skeletal Muscle, and Bone Marrow

Obesity, Volume 34, Issue 3, Page 652-661, March 2026.
ABSTRACT Objective Aging alters mesenchymal stromal cell (MSC) function, leading to dysregulated adipogenesis across tissues through biased lineage commitment. Fat redistribution from adipose depots to skeletal muscle and bone marrow is common in aging, but the underlying mechanisms remain unclear.
Xu Zhang, Madison L. Doolittle, Ting Fan, Utkarsh Tripathi, Yan Er Ng, Xinyi Jiang, João F. Passos, Diana Jurk, David G. Monroe, Tamara Tchkonia, James L. Kirkland, Paul D. Robbins, Sundeep Khosla, Nathan K. LeBrasseur   +13 more
wiley   +1 more source

Senolytic therapy reduces inflammation in epithelial cells from COPD patients and in smoke-exposure mice [PDF]

INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a disease of accelerated lung aging, with increased numbers of senescent cells found within the COPD Lung.
Baker, Jonathan R, Daly, Leah, Hassibi, Shyreen, Ito, Kazuhiro, Kimura, Genki, Kizawa, Yasuo, Nishimoto, Yuki   +6 more
core   +1 more source

Cellular Senescence: The Driving Force of Musculoskeletal Diseases [PDF]

The aging of the world population is closely associated with an increased prevalence of musculoskeletal disorders, such as osteoporosis, sarcopenia, and osteoarthritis, due to common genetic, endocrine, and mechanical risk factors.
Angela Chiavoghilefu, Angela Falvino, Annalisa Botta, Beatrice Gasperini, Elena Gasbarra, Ida Cariati, Roberto Bonanni, Umberto Tarantino, Virginia Tancredi   +8 more
core   +1 more source

Host Aging Induces a Senescent‐Like Phenotype in Neutrophils and Altered Transcriptional Responses to Streptococcus pneumoniae

Aging Cell, Volume 25, Issue 3, March 2026.
Aging is associated with a senescent‐like phenotype in neutrophils that emerges in bone marrow cells; however, many facets of this phenotype are only fully acquired upon entry into peripheral tissues. This neutrophil senescent‐like phenotype is in part driven by TNFα and impairs resistance of aged hosts to S. pneumoniae. Created in BioRender. Boughanem
Michael C. Battaglia, Manmeet Bhalla, Brandon Marzullo, Anagha Betadpur, Alexsandra P. Lenhard, Rania Hassan Mohamed, Murat C. Kalem, Lauren R. Heinzinger, Pathricia A. Leus, Samuel Labarron, Lee Ann Garrett‐Sinha, Joan Mecsas, Anna Blumental‐Perry, Elsa N. Bou Ghanem   +13 more
wiley   +1 more source

Decoding Senescence‐Driven Heterogeneity in Early‐Onset Colorectal Cancer for Prognostic and Therapeutic Stratification

Cancer Science, Volume 117, Issue 3, Page 818-835, March 2026.
We uncovered pronounced and heterogeneous tumor senescence in EOCRC, independent of age. By integrating multi‐omics and single‐cell analyses, we developed EO‐Senscore, a prognostic tool that stratifies patients by immune phenotype and therapy response, enabling precision treatment using immunotherapy or senolytic agents. ABSTRACT Early‐onset colorectal
Du Cai, Mingru Mai, Rende Huang, Haoning Qi, Xingzhi Feng, Qianling Gao, Yinmeng Zhang, Chenghang Li, Xiaojian Wu, Yize Mao, Zihuan Yang, Feng Gao   +11 more
wiley   +1 more source

Mechanisms of Senescence and Anti-Senescence Strategies in the Skin

Biology
The skin is the layer of tissue that covers the largest part of the body in vertebrates, and its main function is to act as a protective barrier against external environmental factors, such as microorganisms, ultraviolet light and mechanical damage.
Evangelia Konstantinou, Eliane Longange, Gürkan Kaya   +2 more
doaj   +1 more source