Results 131 to 140 of about 6,287 (219)
The senotherapeutic potential of phytochemicals for age-related intestinal disease [PDF]
During the last few decades, life expectancy has increased worldwide along with the prevalence of several age-related diseases. Among aging pathways, cellular senescence and chronic inflammation (or “inflammaging”) appear to be connected to gut ...
Costa, Célia Maria +4 more
core +1 more source
A Senolytic Strategy for Metabolic Health: Why the Endothelium Matters
iNew Medicine, Volume 2, Issue 1, March 2026.
He Liang +3 more
wiley +1 more source
European Journal of Haematology, Volume 116, Issue 3, Page 302-310, March 2026.ABSTRACT Since 2004, patients receiving imatinib with relapse in non‐marrow sites were given dasatinib to preserve control of leukemic marrow. Remissions in CNS and other organs began to be reported and are continuously observed to present. With resistance to one BCR::ABL1 tyrosine kinase inhibitor and sensitivity to a dual BCR::ABL1/SRC inhibitor ...
I. Cunningham +4 more
wiley +1 more source
Integrative Omics Reveal Female‐Specific Benefits of p16+ Cell Clearance in Aging Mice
Advanced ScienceAging is marked by the accumulation of cells expressing the cyclin‐dependent kinase inhibitor p16Ink4a. These p16⁺ cells, largely senescent, contribute to inflammation and tissue dysfunction. While eliminating p16⁺ cells improves healthspan, sex‐specific
Yao Lin +4 more
doaj +1 more source
Journal of the American Geriatrics Society, Volume 74, Issue 3, Page 854-867, March 2026.ABSTRACT Introduction Although frailty is considered a potentially modifiable risk factor for dementia, its influence on health outcomes in individuals with established dementia remains unclear. This study aims to systematize the current evidence to understand the impact of frailty on the development of adverse outcomes in older adults with dementia ...
Miguel German Borda +11 more
wiley +1 more source
Therapy-induced senescence in prostate cancer: mechanisms, therapeutic strategies, and clinical implications [PDF]
Cellular senescence; Prostate cancer; Senescence-associated secretory phenotypeSenescència cel·lular; Càncer de pròstata; Fenotip secretor associat a la senescènciaSenescencia celular; Cáncer de próstata; Fenotipo secretor asociado a la ...
Bacca, Luisa +5 more
core +1 more source
The “Reducing Inflammation for Greater Health Trial (RIGHT)” Study—Concept, Rationale, and Design
Journal of the American Geriatrics Society, Volume 74, Issue 3, Page 636-647, March 2026.ABSTRACT The Reducing Inflammation for Greater Health Trial's (RIGHT) study is a single‐center, randomized, double‐blind, placebo‐controlled trial designed to test whether clazkizumab, an interleukin‐6 (IL‐6) inhibitor, can improve or slow decline in physical, cognitive, and vascular function in older adults, when compared to a placebo.
Sebastian E. Sattui +11 more
wiley +1 more source
Frontiers in ImmunologyThe senescence of immune cells has also emerged as a key hallmark of immunological dysregulation and chronic inflammation in autoimmunity. Senescent immune cells are irreversibly arrested in the cell cycle, exhibit antimetabolic characteristics, and ...
Fei Yin, Yangfang He, Jian Li, Yuan Gao
doaj +1 more source