Results 141 to 150 of about 6,287 (219)

Senomorphic Activity of a Novel Standardized Propolis Extract in Human Dermal Fibroblasts: Molecular Insights Into Clinically Proven Anti‐Wrinkle Efficacy

Journal of Cosmetic Dermatology, Volume 25, Issue 3, March 2026.
ABSTRACT Background We recently demonstrated in a randomized controlled trial (RCT) that a Standardized Propolis Extract (SPE), produced via a patented non‐alcoholic PEG 400/lecithin process, achieves significant clinical anti‐wrinkle efficacy (34% wrinkle depth reduction).
Božo Radić, Jelena Šuran
wiley   +1 more source

Senolytic Interventions for Type 2 Diabetes: Current Evidence and Future Directions

Diabetology
Cellular senescence, a phenomenon characterized by the accumulation of dysfunctional, metabolically active cells, is increasingly recognized to be a key player in aging-related metabolic disorders.
Selene Sodini, Milton Fabián Suarez-Ortegón   +1 more
doaj   +1 more source

New Insights into the Role of Cellular Senescence and Its Therapeutic Implications in Ocular Diseases

Bioengineering
The process of aging exerts profound effects on various physiological systems, leading to the progression of chronic degenerative disorders and pathologies associated with advancing age.
Junying Wu, Xiuxing Liu, Yidan Liu, Wenru Su, Yehong Zhuo   +4 more
doaj   +1 more source

Regulation of intestinal senescence during cholestatic liver disease modulates barrier function and liver disease progression

JHEP Reports
Background & Aims: Senescence has been reported to have differential functions in cholangiocytes and hepatic stellate cells (HSCs) during human and murine cholestatic disease, being detrimental in biliary cells and anti-fibrotic in HSCs.
Mar Moreno-Gonzalez, Katherine Hampton, Paula Ruiz, Gemma Beasy, Falk SP. Nagies, Aimee Parker, James Lazenby, Caitlin Bone, Ane Alava-Arteaga, Meha Patel, Charlotte Hellmich, Pablo Luri-Martin, Ece Silan, Mark Philo, David Baker, Simon M. Rushbrook, Falk Hildebrand, Stuart A. Rushworth, Naiara Beraza   +18 more
doaj   +1 more source

Polyploid superficial uroepithelial bladder barrier cells express features of cellular senescence across the lifespan and are insensitive to senolytics. [PDF]

Lower urinary tract dysfunction (LUTD) increases with aging. Ensuing symptoms including incontinence greatly impact quality of life, isolation, depression, and nursing home admission.
Al-Naggar, Iman M, Antony, Maria, Baker, Dylan, Fraser, Matthew O, Godoy, Lucas Da Cunha, Kuchel, George A, Kuo, Chia-Ling, Smith, Phillip P, Wang, Lichao, Xu, Ming   +9 more
core   +2 more sources

Apoptotic vesicle-mediated senolytics requires mechanical loading

Theranostics
Rationale: Mechanical force plays crucial roles in extracellular vesicle biogenesis, release, composition and activity. However, it is unknown whether mechanical force regulates apoptotic vesicle (apoV) production. Methods: The effects of mechanical unloading on extracellular vesicles of bone marrow were evaluated through morphology, size distribution,
Xue, Zhulin, Jiang, Yexiang, Meng, Bowen, Lu, Lu, Hao, Meng, Zhang, Yi, Shi, Songtao, Li, Zili, Mao, Xueli   +8 more
openaire   +2 more sources

Senescence of skeletal stem cells and their contribution to age-related bone loss [PDF]

Human aging is linked to bone loss, resulting in bone fragility and an increased risk of fractures. This is primarily due to an age-related decline in the function of bone-forming osteoblastic cells and accelerated cellular senescence within the bone ...
Elkjær, Anna Sofie, Fernandez-Guerra, Paula, Figeac, Florence, Jeromdesella, Shakespeare, Kassem, Moustapha, Kjær, Pernille Kirkegaard, Nørgård, Mikkel Ørnfeldt, Wölfel, Eva M.   +7 more
core   +1 more source

Targeting anxiety and senescence with senolytics

Aging, 2022
Raffaele, Marco, Vinciguerra, Manlio
openaire   +2 more sources

Paradoxes of senolytics

Aging, 2018
openaire   +2 more sources

Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers. [PDF]

Aging Cell
Tripathi U, Suda M, Kulshreshtha V, Piatkowski BT, Palmer AK, Giorgadze N, Inman C, Gasek N, Xu M, Johnson KO, Pirtskhalava T, Chaib S, Langhi Prata LPG, Zhu Y, Kandhaya-Pillai R, Tullius SG, Wyles SP, Majji R, Yalamanchili HK, Allison DB, Tchkonia T, Kirkland JL.   +21 more
europepmc   +1 more source