Results 11 to 20 of about 6,287 (219)

Discovery of senolytics using machine learning

Nature Communications, 2023
Cellular senescence is a stress response involved in ageing and diverse disease processes including cancer, type-2 diabetes, osteoarthritis and viral infection.
Vanessa Smer-Barreto, Andrea Quintanilla, Richard J. R. Elliott, John C. Dawson, Jiugeng Sun, Víctor M. Campa, Álvaro Lorente-Macías, Asier Unciti-Broceta, Neil O. Carragher, Juan Carlos Acosta, Diego A. Oyarzún   +10 more
doaj   +6 more sources

Senolytics in the treatment of diabetic retinopathy

Frontiers in Pharmacology, 2022
Diabetic retinopathy (DR) is the most common complication of diabetes. DR is characterized by damage to retinal vasculature resulting in vision impairment and, if untreated, could eventually lead to blindness.
Jannah Waled Hassan, Ashay D. Bhatwadekar   +1 more
doaj   +4 more sources

A pipeline for senolytics

The Journal of Clinical Investigation
There is intense interest in identifying compounds that selectively kill senescent cells, termed senolytics, for ameliorating age-related comorbidities.
Sundeep Khosla
doaj   +3 more sources

Cardiac glycosides are broad-spectrum senolytics [PDF]

Nature Metabolism, 2019
Senescence is a cellular stress response that results in the stable arrest of old, damaged or pre-neoplastic cells. Oncogene-induced senescence is tumour suppressive but can also exacerbate tumorigenesis through the secretion of proinflammatory factors ...
Guerrero, A, Herranz, N, Sun, B, Wagner, V, Gallage, S, Guiho, R, Wolter, K, Pombo, J, Irvine, EE, Innes, AJ, Birch, J, Glegola, J, Manshaei, S, Heide, D, Dharmalingam, G, Harbig, J, Olona, A, Behmoaras, J, Dauch, D, Uren, AG, Zender, L, Vernia, S, Martínez-Barbera, JP, Heikenwalder, M, Withers, DJ, Gil, J   +25 more
core   +7 more sources

DNA Methylation Signatures of Cellular Senescence Are Not Reversed by Senolytic Treatment. [PDF]

Aging Cell
We found very little overlap between CpGs that were correlated with in vitro senescence, chronological age, and mortality. While we were able to train epigenetic clocks with CpGs that accelerated with cellular senescence, these clocks did not decelerate with Senolytic treatment. ABSTRACT Epigenetic clocks are commonly used aging biomarkers based on DNA
Kasamoto J, González J, Markov Y, Sehgal R, Lee E, Dwaraka VB, Smith R, Higgins-Chen AT.   +7 more
europepmc   +2 more sources

Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. [PDF]

, 2020
The accumulation of senescent cells (SnCs) is a causal factor of various age-related diseases as well as some of the side effects of chemotherapy. Pharmacological elimination of SnCs (senolysis) has the potential to be developed into novel therapeutic ...
Budamagunta, Vivekananda, Campisi, Judith, He, Yonghan, Li, Wen, Lv, Dongwen, Ortiz, Yuma T, Zhang, Xin, Zhang, Xuan, Zheng, Guangrong, Zhou, Daohong   +9 more
core   +1 more source

Cardiac Glycosides as Senolytic Compounds [PDF]

Trends in Molecular Medicine, 2020
The identification of senolytics, compounds that eliminate senescent cells, is presently a key priority given their therapeutic promise in cancer and aging-associated diseases. Two recent papers by Triana-Martínez et al. and Guerrero et al. report the senolytic activity of cardiac glycosides (CGs) and their efficacy in these pathophysiological contexts.
Martin, Nadine, Soriani, Olivier, Bernard, David   +2 more
openaire   +2 more sources

The emerging role of cellular senescence in renal diseases [PDF]

, 2020
Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco, Chen, Rong, Francis, Heather, Glaser, Shannon, Li, Siwen, Li, Xuesen, Meng, Fanyin, Wan, Ying, Wu, Nan, Zhang, Chunmei, Zhou, Bingru, Zhou, Tianhao, Zou, Ping   +12 more
core   +1 more source

Bone marrow senescence and the microenvironment of hematological malignancies [PDF]

, 2020
Senescence is the irreversible arrest of cell proliferation that has now been shown to play an important role in both health and disease. With increasing age senescent cells accumulate throughout the body, including the bone marrow and this has been ...
Bowles, Kristian M., Hellmich, Charlotte, Moore, Jamie A., Rushworth, Stuart A.   +3 more
core   +1 more source

Bioinformatics procedure for investigating senolytic (anti‐aging) agents: A digital signal processing technique

Aging Medicine, 2023
Objective Cell growth involves cell division. This stops after reaching a certain limit. Some cells become inactive and unable to undergo apoptosis (programmed cell death).
Norbert Nwankwo, Ignatius Okafor
doaj   +1 more source