Results 21 to 30 of about 6,287 (219)

Unleashing endogenous regeneration by senolytics. [PDF]

J Transl Med
Boddu NK, Kesari S, Chavez BA, Bajnath A, Wheatley MD, Zhang Q, Wang Y, Ellis J, Lin E, Genovese J, Robles MFN.   +10 more
europepmc   +2 more sources

Strategies for senolytic drug discovery

Aging Cell, 2023
AbstractSenolytics are a category of drugs that reduce the impact of cellular senescence, an effect associated with a range of chronic and age‐related diseases. Since the discovery of the first senolytics in 2015, the number of known senolytic agents has grown dramatically.
Helen Power, Peter Valtchev, Fariba Dehghani, Aaron Schindeler   +3 more
openaire   +2 more sources

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

Nature Communications, 2020
Senolytics have the potential to extend healthspan by selectively killing senescent cells (SCs), but senolytics that target Bcl-xl may cause platelet toxicity.
Yonghan He, Xuan Zhang, Jianhui Chang, Ha-Neui Kim, Peiyi Zhang, Yingying Wang, Sajid Khan, Xingui Liu, Xin Zhang, Dongwen Lv, Lin Song, Wen Li, Dinesh Thummuri, Yaxia Yuan, Janet S. Wiegand, Yuma T. Ortiz, Vivekananda Budamagunta, Jennifer H. Elisseeff, Judith Campisi, Maria Almeida, Guangrong Zheng, Daohong Zhou   +21 more
doaj   +1 more source

Chemoinformatic Screening for the Selection of Potential Senolytic Compounds from Natural Products

Biomolecules, 2021
Cellular senescence is a cellular condition that involves significant changes in gene expression and the arrest of cell proliferation. Recently, it has been suggested in experimental models that the elimination of senescent cells with pharmacological ...
Oscar Salvador Barrera-Vázquez, Juan Carlos Gómez-Verjan, Gil Alfonso Magos-Guerrero   +2 more
doaj   +1 more source

A proteomic atlas of senescence-associated secretomes for aging biomarker development. [PDF]

, 2020
The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer.
Basisty, Nathan, Campisi, Judith, Ferrucci, Luigi, Holtz, Anja, Jeon, Ok Hee, Kale, Abhijit, Kuehnemann, Chisaka, Payne, Therese, Rao, Chirag, Schilling, Birgit, Shah, Samah, Sharma, Vagisha   +11 more
core   +1 more source

Is it the time of seno-therapeutics application in cardiovascular pathological conditions related to ageing? [PDF]

, 2021
It rates that in 2030, the cardiovascular diseases (CVD) will result in 40% of all deaths and rank as the leading cause. Thus, the research of appropriate therapies able to delay or retard their onset and progression is growing.
Balistreri, Carmela Rita, Ferdinandy, Peter, Madonna, Rosalinda   +2 more
core   +1 more source

Translating Senotherapeutic Interventions into the Clinic with Emerging Proteomic Technologies

Biology, 2023
Cellular senescence is a state of irreversible growth arrest with profound phenotypic changes, including the senescence-associated secretory phenotype (SASP).
Amit K. Dey, Reema Banarjee, Mozhgan Boroumand, Delaney V. Rutherford, Quinn Strassheim, Thedoe Nyunt, Bradley Olinger, Nathan Basisty   +7 more
doaj   +1 more source

Senescence under appraisal: hopes and challenges revisited. [PDF]

, 2021
In recent years, cellular senescence has become the focus of attention in multiple areas of biomedical research. Typically defined as an irreversible cell cycle arrest accompanied by increased cellular growth, metabolic activity and by a characteristic ...
Davan-Wetton, CSA, Montero-Melendez, T, Perretti, M, Pessolano, E   +3 more
core   +1 more source

Cellular Senescence in Cardiovascular Diseases: From Pathogenesis to Therapeutic Challenges

Journal of Cardiovascular Development and Disease, 2023
Cellular senescence (CS), classically considered a stable cell cycle withdrawal, is hallmarked by a progressive decrease in cell growth, differentiation, and biological activities.
Dan Li, Yongnan Li, Hong Ding, Yuqin Wang, Yafei Xie, Xiaowei Zhang   +5 more
doaj   +1 more source

Galactose‐modified duocarmycin prodrugs as senolytics [PDF]

Aging Cell, 2019
Abstract Senescence is a stable growth arrest that impairs the replication of damaged, old or preneoplastic cells, therefore contributing to tissue homeostasis. Senescent cells accumulate during ageing and are associated with cancer, fibrosis and many age‐related pathologies.
Guerrero, Ana, Guiho, Romain, Herranz, Nicolás, Uren, Anthony, Withers, Dominic J., Martínez-Barbera, Juan Pedro, Tietze, Lutz F., Gil, Jesús   +7 more
openaire   +7 more sources