Results 31 to 40 of about 6,287 (219)
Ethical perspectives on advances in biogerontology [PDF]
, 2019 Worldwide populations are aging with economic development as a result of public health initiatives and advances in therapeutic discoveries. Since 1850, life expectancy has advanced by 1 year for every four.
Archard, David +8 more
core +1 more source
Deletion of SA β-Gal+ Cells Using Senolytics Improves Muscle Regeneration in Old Mice [PDF]
, 2021 Systemic deletion of senescent cells leads to robust improvements in cognitive, cardiovascular, and whole-body metabolism, but their role in tissue reparative processes is incompletely understood.
Brightwell, Camille R. +12 more
core +2 more sources
Senescence and the SASP: many therapeutic avenues [PDF]
, 2020 Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP).
Birch, J, Gil, J
core +1 more source
EBioMedicine, 2019 Background: Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with ageing and at etiological sites in multiple chronic diseases.
LaTonya J. Hickson +32 more
doaj +1 more source
Black Ginseng Ameliorates Cellular Senescence via p53-p21/p16 Pathway in Aged Mice
Biology, 2022 Cellular senescence, one of the hallmarks of aging, refers to permanent cell cycle arrest and is accelerated during the aging process. Black ginseng (BG), prepared by a repeated steaming and drying process nine times from fresh ginseng (Panax ginseng C.A.
Su-Jeong Lee +4 more
doaj +1 more source
Primary Graft Dysfunction: The Role of Aging in Lung Ischemia-Reperfusion Injury
Frontiers in Immunology, 2022 Transplant centers around the world have been using extended criteria donors to remedy the ongoing demand for lung transplantation. With a rapidly aging population, older donors are increasingly considered.
Maximilian J. Roesel +10 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Objective: The field of targeting cellular senescence with drug candidates to address age-related comorbidities has witnessed a notable surge of interest and research and development.
Li Ping Wong +7 more
doaj +1 more source
A novel suicide gene therapy for the treatment of p16-overexpressing tumors [PDF]
, 2017 p16Ink4ais a potent cell cycle inhibitor engaged to support cell cycle arrest during cellular senescence. However, in tumors carrying mutations in key downstream effectors, p16Ink4ais highly expressed but fails to block cell proliferation.
Campisi, Judith +2 more
core +2 more sources
Evaluating the neuroprotective impact of senolytic drugs on human vision
Scientific Reports, 2020 Glaucoma, a chronic neurodegenerative disease of retinal ganglion cells (RGCs), is a leading cause of irreversible blindness worldwide. Its management currently focuses on lowering intraocular pressure to slow disease progression.
Nevin W. El-Nimri +6 more
doaj +1 more source
Cells, 2023 Landmark genetic studies have revealed the effect of complement biology and its regulation on the pathogenesis of age-related macular degeneration (AMD).
Adnan H. Khan +2 more
doaj +1 more source