Results 41 to 50 of about 6,287 (219)
Photoactivatable senolysis with single-cell resolution delays aging [PDF]
, 2023 Strategies that can selectively eliminate senescent cells (SnCs), namely senolytics, have been shown to promote healthy lifespan. However, it is challenging to achieve precise, broad-spectrum and tractable senolysis.
Gao, Ying +8 more
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Senolytic drugs: from discovery to translation [PDF]
Journal of Internal Medicine, 2020 AbstractSenolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis‐driven approach. SC accumulate with ageing and at causal sites of multiple chronic disorders, including diseases accounting for the bulk of morbidity, mortality ...
J. L. Kirkland, T. Tchkonia
openaire +2 more sources
Endothelial Senescence and the Chronic Vascular Diseases: Challenges and Therapeutic Opportunities in Atherosclerosis [PDF]
, 2022 Atherosclerosis is probably one of the paradigms of disease linked to aging. Underlying the physiopathology of atherosclerosis are cellular senescence, oxidative stress, and inflammation.
Alique Aguilar, Matilde +5 more
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DNA damage: A main determinant of vascular aging [PDF]
, 2016 Vascular aging plays a central role in health problems and mortality in older people. Apart from the impact of several classical cardiovascular risk factors on the vasculature, chronological aging remains the single most important determinant of ...
Bautista-Niño, P.K. (Paula) +4 more
core +2 more sources
From the divergence of senescent cell fates to mechanisms and selectivity of senolytic drugs
Open Biology, 2022 Senescence is a cellular stress response that involves prolonged cell survival, a quasi-irreversible proliferative arrest and a modification of the transcriptome that sometimes includes inflammatory gene expression.
Valentin L'Hôte +2 more
doaj +1 more source
The Evolving Role of CD8+CD28- Immunosenescent T Cells in Cancer Immunology [PDF]
, 2019 Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune response to cancer. Thus, induction of their activity is the ultimate aim of all immunotherapies.
Dey, Mahua +4 more
core +1 more source
From genoprotection to rejuvenation
Frontiers in Bioscience-Landmark, 2020 Aging results from aberrations in signaling mechanisms and decline in biologic activities and cellular functions. Anti-aging strategies include a number of dietary, genetic, and pharmacological interventions that converge on a core network of nutrient ...
Siamak Tabibzadeh
doaj +1 more source
New Trends in Aging Drug Discovery [PDF]
, 2022 Aging is considered the main risk factor for many chronic diseases that frequently appear at advanced ages. However, the inevitability of this process is being questioned by recent research that suggests that senescent cells have specific features that ...
Benhamú Salama, Bellinda +4 more
core +2 more sources
Pharmacology Research & Perspectives, 2023 Previous investigations have demonstrated that treatment of animals with rapamycin increases levels of autophagy, which is a process by which cells degrade intracellular detritus, thus suppressing the emergence of senescent cells, whose pro‐inflammatory ...
Kitti Szőke +8 more
doaj +1 more source
Nature Biotechnology, 2020 Despite early failures in the clinic, the idea of anti-aging therapies that purge the body of dying cells is gaining traction with a raft of startups now focused on senescence.
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