Scientific ReportsIntrinsic and extrinsic factors, including lifestyle and sun exposure, can contribute to cell senescence, which impairs skin homeostasis, that may in turn lead to skin aging.
Patrick Bogdanowicz +10 more
doaj +1 more source
Inhibition of the metalloprotease ADAM19 as a novel senomorphic strategy to ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP). [PDF]
Accumulation of DNA damage can accelerate aging through cellular senescence. Previously, we established a Drosophila model to investigate the effects of radiation-induced DNA damage on the intestine.
Bar, Sudipta +10 more
core +2 more sources
The interplay between cell death and senescence in cancer [PDF]
Seminars in Cancer Biology.
Inuzuka, Hiroyuki +2 more
core +1 more source
Aging Cell, Volume 25, Issue 2, February 2026.Using in vitro DNA damage assays in human T cells, ex vivo profiling of aged immune subsets and a small placebo‐controlled in vivo study, authors show that low‐dose rapamycin, a potent life‐extending mTOR inhibitor, enhances resilience against DNA damage in the human immune system.
Loren Kell +8 more
wiley +1 more source
Senotherapeutics to Counteract Senescent Cells Are Prominent Topics in the Context of Anti-Ageing Strategies [PDF]
Cellular senescence is implicated in ageing and associated with a broad spectrum of agerelated diseases. Importantly, a cell can initiate the senescence program irrespective of the organism’s age.
Accardi, Giulia +5 more
core +1 more source
The Secretome of Human Trophoblast Stem Cells Attenuates Senescence‐Associated Traits
Aging Cell, Volume 25, Issue 2, February 2026.Human trophoblast stem cell‐derived secretome/conditioned medium (hTSC‐CM) and the extracellular vesicles (EVs) therein suppress DNA damage and NF‐κB activation in senescent fibroblasts, in turn reducing the production of senescence‐associated secretory phenotype (SASP) factors. This study highlights hTSC‐CM and EVs as potential senotherapeutic agents.
Kotb Abdelmohsen +18 more
wiley +1 more source
Senescent cells as a target for anti-aging interventions: From senolytics to immune therapies [PDF]
Aging and age-related diseases are major drivers of multimorbidity and mortality worldwide. Cellular senescence is a hallmark of aging. The accumulation of senescent cells is causally associated with pathogenesis of various age-associated disorders.
Fu, Tianlu Esther, Zhou, Zhongjun
core +1 more source
Engineering Aging: Approaches to Model and Deconstruct Biological Complexity
Advanced Materials, Volume 38, Issue 1, 2 January 2026.The macro‐experiences of aging are the result of an accumulation of micro‐changes that occur over time. Abstract The disparity between the global increase in life expectancy and the steady decline in health outcomes with age has been a major driver for developing new ways to research aging.
Habib Joukhdar +7 more
wiley +1 more source
Effective and Stable Senomorphic Apigenin Delivery System Obtained by Supercritical Carbon Dioxide Processing. [PDF]
Int J Mol SciApigenin (AP) is a natural flavonoid with senomorphic potential and neuroprotective action; however, poor aqueous solubility (<1 μg/mL) limits its bioavailability and therapeutic use. Therefore, the aim of this study was to obtain an amorphous dispersion of AP and evaluate its biological properties.
Stasiłowicz-Krzemień A +4 more
europepmc +3 more sources
Screening for senolytic and senomorphic compounds in HDF76 fibroblasts and their effects as geroprotectors in C. elegans [PDF]
El envejecimiento es el principal factor de riesgo para muchas enfermedades, y la senescencia celular es un factor clave en este proceso y sus patologías relacionadas.
Sanguinet Rumayor, Sybila
core