Results 101 to 110 of about 1,457 (176)

Integrative Omics Reveal Female‐Specific Benefits of p16+ Cell Clearance in Aging Mice

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Aging causes accumulation of p16⁺ senescent cells that promote inflammation and dysfunction. Multi‐omics analyses reveal striking sex differences in senescent cell burden and clearance: females accumulate more p16⁺ cells, especially in the liver, and their removal rejuvenates molecular and functional profiles.
Yao Lin, Boshi Wang, Mengling Huang, Justina C. Wolters, Marco Demaria   +4 more
wiley   +1 more source

The role of p21 in cellular senescence and aging-related diseases

Molecules and Cells
: During the aging process or disease progression, normal cells and tissues in the body undergo various stresses, leading to cell damage and the need for repair, adaptation, apoptosis, or defense responses.
Jiayu Yan, Siyi Chen, Zimei Yi, Ruowen Zhao, Jiayu Zhu, Shuwen Ding, Junhua Wu   +6 more
doaj   +1 more source

Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging [PDF]

Endothelial cell senescence is a key driver of cardiovascular aging, yet little is known about the mechanisms by which it is induced in vivo. Here we show that the gut bacterial metabolite phenylacetic acid (PAA) and its byproduct, phenylacetylglutamine (
Alimonti, Andrea, Allemann, Meret Sarah, Attaye, Ilias, Beer, Jürg H, Colucci, Manuel, Constancias, Florentin, Falchi, Mario, Karsai, Gergely, Le Gludic, Sylvain, Lee, Pratintip, Menni, Cristina, Paneni, Francesco, Pugin, Benoit, Ruschitzka, Frank, Saeedi Saravi, Seyed Soheil, Shabanian, Khatereh, Shabanian, Taraneh, Spalinger, Marianne, Thomas, Aurélien, Visconti, Alessia, Zhang, Xinyuan   +20 more
core   +4 more sources

Senolytic‐Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers

Aging Cell, Volume 25, Issue 1, January 2026.
The SC subtype with a pro‐inflammatory, proapoptotic, tissue‐damaging SASP is susceptible to senolytics. The SC subset not killed by senolytics has a pro‐growth/repair SASP. “Senosensitizers” that induce senolytic‐resistant SCs to be converted into SCs that are susceptible to senolytics could enable removal of relatively silent SCs.
Utkarsh Tripathi, Masayoshi Suda, Vagisha Kulshreshtha, Bryan T. Piatkowski, Allyson K. Palmer, Nino Giorgadze, Christina Inman, Nathan Gasek, Ming Xu, Kurt O. Johnson, Tamar Pirtskhalava, Selim Chaib, Larissa P. G. Langhi Prata, Yi Zhu, Renuka Kandhaya‐Pillai, Stefan G. Tullius, Saranya P. Wyles, Rambabu Majji, Hari Krishna Yalamanchili, David B. Allison, Tamar Tchkonia, James L. Kirkland   +21 more
wiley   +1 more source

Divergent regulation of long non-coding RNAs H19 and PURPL affects cell senescence in human dermal fibroblasts [PDF]

Cellular senescence is a permanent cell growth arrest that occurs in response to various intrinsic and extrinsic stimuli and is associated with cellular and molecular changes.
Anceschi, Cecilia, Battaglia, Cristina, Chillà, Anastasia, Del Rosso, Mario, Fibbi, Gabriella, Frediani, Elena, Germiniani, Claudia Elena Zoe, Giovannelli, Lisa, Laurenzana, Anna, Margheri, Francesca, Mocali, Alessandra, Nerini, Alice, Ristori, Sara, Ruzzolini, Jessica, Venturin, Marco   +14 more
core   +4 more sources

Cellular Senescence, Inflammaging and Cardiovascular Disease

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Aging is the most important yet unmodifiable risk factor for cardiovascular disease (CVD). As a result, targeting cardiovascular aging has emerged as a promising strategy to promote long‐term cardiovascular health. This review summarizes current knowledge on the effects of aging within the cardiovascular system as well as systemic processes ...
Lukas Zanders, Denada Arifaj, Julian U. G. Wagner, Stefanie Dimmeler   +3 more
wiley   +1 more source

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy [PDF]

, 2019
Research paper[Abstract] Background. Ageing-related failure of homeostasis mechanisms contributes to articular cartilage degeneration and osteoarthritis (OA), for which disease-modifying treatments are not available.
Blanco García, Francisco J, Caramés, Beatriz, Domínguez, Eduardo, Grassi, Diego, Lorenzo-Gómez, Irene, Lotz, Martin, Loza, María Isabel, Nogueira Recalde, Uxía, Robbins, Paul D., Shirinsky, Ivan, Shirinsky, Valery   +10 more
core   +2 more sources

Editorial: Cellular senescence in physiology and pathophysiology

Frontiers in Physiology, 2023
Mustafa Ark, Mohammad Nasir Uddin
doaj   +1 more source

Regorafenib as a potential drug for severe COVID‐19: inhibition of inflammasome activation in mice

FEBS Open Bio
SARS‐CoV‐2 infection can lead to severe COVID‐19, particularly in elderly individuals and those with compromised immunity. Cellular senescence has been implicated as a key pathogenic mechanism.
Ju Hwan Jeong, Sun‐Ok Kim, Seong Cheol Min, Eung‐Gook Kim, Min‐Suk Song, Eun‐Young Shin   +5 more
doaj   +1 more source

Senescence and SASP Are Potential Therapeutic Targets for Ischemic Stroke

Pharmaceuticals
Aging is a known co-morbidity of ischemic stroke with its risk and severity increasing every year past 55+. While many of the current stroke therapies have shown success in reducing mortality, post-stroke morbidity has not seen the same substantial ...
Blake Ouvrier, Saifudeen Ismael, Gregory Jaye Bix   +2 more
doaj   +1 more source