Results 111 to 120 of about 1,457 (176)

The role of chondrocyte senescence in osteoarthritis pathogenesis and therapeutic implications

Experimental Gerontology
Osteoarthritis (OA) is a common and debilitating joint disorder, with its pathogenesis significantly influenced by factors such as aging and obesity.
Kai Huang, Haili Cai
doaj   +1 more source

Viscosupplementation and Synovial Fluid Rheology: A Hidden Risk for Bacterial Biofilm Formation in Joint Infections? [PDF]

Synovial fluid (SF) plays a critical role in joint lubrication, load distribution, and maintaining homeostasis within the synovial cavity. Its rheological properties, primarily influenced by hyaluronic acid (HA) and other macromolecules, are essential ...
Fabiana Giarritiello, Lorenzo Drago, Luigi Regenburgh De La Motte   +2 more
core   +1 more source

ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation

Nature Communications
Senescence-associated secretory phenotype (SASP) mediates the biological effects of senescent cells on the tissue microenvironment and contributes to ageing-associated disease progression.
Li Yang, Jianwei You, Xincheng Yang, Ruishu Jiao, Jie Xu, Yue zhang, Wen Mi, Lingzhi Zhu, Youqiong Ye, Ruobing Ren, Delin Min, Meilin Tang, Li Chen, Fuming Li, Pingyu Liu   +14 more
doaj   +1 more source

Gene therapy for fat-1 prevents obesity-induced metabolic dysfunction, cellular senescence, and osteoarthritis [PDF]

Obesity is one of the primary risk factors for osteoarthritis (OA), acting through cross talk among altered biomechanics, metabolism, adipokines, and dietary free fatty acid (FA) composition.
Choi, Yun-Rak, Guilak, Farshid, Harasymowicz, Natalia S, Lenz, Kristin, Oswald, Sara J, Tang, Ruhang, Wu, Chia-Lung   +6 more
core   +2 more sources

Natural Products Acting as Senolytics and Senomorphics Alleviate Cardiovascular Diseases by Targeting Senescent Cells

Targets
Taken together, cardiovascular diseases (CVDs) have become one of the prime causes of the global disease burden. Aging is closely related to CVDs and is considered to be one of the crucial factors in the incidence of CVDs. In the process of aging, cellular senescence is an important cause of CVDs such as atherosclerosis and atrial fibrillation.
Hejing Tang, Xu Zhang, Senyang Hu, Yuhan Song, Wenhua Jin, Jianmin Zou, Yan Zhang, Jiayue Guo, Peng An, Junjie Luo, Pengjie Wang, Yongting Luo, Yinhua Zhu   +12 more
openaire   +1 more source

Apigenin and Phloretin Combination for Skin Aging and Hyperpigmentation Regulation

Cosmetics
Melasma is a pathology with multifactorial causes that results in hyperpigmentation of sun-exposed areas, particularly facial skin. New treatments targeting the different factors regulating this condition need to be effective with and have limited ...
Alfredo Martínez-Gutiérrez, Javier Sendros, Teresa Noya, Mari Carmen González   +3 more
doaj   +1 more source

Aging and Senotherapeutics [PDF]

, 2019
One of the key mechanisms of the aging process of an organism and of the dysfunctionality and chronic diseases related with aging is the so-called cell senescence.
Ivana Čepelak, Slavica Dodig
core   +2 more sources

Targeting senescent cells in aging and COVID-19: from cellular mechanisms to therapeutic opportunities

Cell Regeneration
The COVID-19 pandemic has caused a global health crisis and significant social economic burden. While most individuals experience mild or non-specific symptoms, elderly individuals are at a higher risk of developing severe symptoms and life-threatening ...
Yuan Yu, Kaixuan Lin, Haoyu Wu, Mingli Hu, Xuejie Yang, Jie Wang, Johannes Grillari, Jiekai Chen   +7 more
doaj   +1 more source

Targeting senescence in Lymphangioleyomyomatosis through senomorphic-like molecules as a paradigm to counteract senescence in lung tumor microenvironment [PDF]

Lymphangioleiomyomatosis (LAM) is a pulmonary low-grade, destructive, metastasizing rare neoplasm occurring in young women as a sporadic disorder or in association with tuberous sclerosis complex (TSC, LAM/TSC).
Bernardelli C., Cappello G., Di Fede E., Gervasini C., Lesma E., Massa V., Rosa S., Selvaggio P., Taci E.   +8 more
core  

The Quest for Eternal Youth: Hallmarks of Aging and Rejuvenating Therapeutic Strategies

Biomedicines
The impressive achievements made in the last century in extending the lifespan have led to a significant growth rate of elderly individuals in populations across the world and an exponential increase in the incidence of age-related conditions such as ...
Vharoon Sharma Nunkoo, Alexander Cristian, Anamaria Jurcau, Razvan Gabriel Diaconu, Maria Carolina Jurcau   +4 more
doaj   +1 more source