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Emerging use of senolytics and senomorphics against aging and chronic diseases
Medicinal Research Reviews, 2020AbstractSenescence is a state of cell cycle arrest that plays an important role in embryogenesis, wound healing and protection against cancer. Senescent cells also accumulate during aging and contribute to the development of age‐related disorders and chronic diseases, such as atherosclerosis, type 2 diabetes, osteoarthritis, idiopathic pulmonary ...
Jan Martel +7 more
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Biogerontology, 2022
Senescent cells accumulate within tissues during aging and secrete an array of pro-inflammatory molecules known as senescent-associated secretory phenotype (SASP), which contribute to the appearance and progression of various chronic degenerative diseases.
Kevin Samael Olascoaga-Del Angel +4 more
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Senescent cells accumulate within tissues during aging and secrete an array of pro-inflammatory molecules known as senescent-associated secretory phenotype (SASP), which contribute to the appearance and progression of various chronic degenerative diseases.
Kevin Samael Olascoaga-Del Angel +4 more
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Senomorphic properties of miR-181b in aged human aortic smooth muscle cells
Physiology, 2023Introduction: Age associated large artery stiffness (LAS) is an independent predictor of adverse cardiovascular health outcomes in humans and has also been shown to be associated with the development of heart failure, kidney disease, and even dementia.
Denisse Moreno +5 more
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Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction
2023The accumulation of senescent cells in the aging individual is associated with an increase in the occurrence of age-associated pathologies that contribute to poor health, frailty, and mortality. The number and type of senescent cells is viewed as a contributor to the body's senescence burden.
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Free Radical Biology and Medicine, 2021
Cellular senescence is a heterogeneous process guided by genetic, epigenetic and environmental factors, characterizing many types of somatic cells. It has been suggested as an aging hallmark that is believed to contribute to aging and chronic diseases.
Lagoumtzi, Sofia M, Chondrogianni, Niki
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Cellular senescence is a heterogeneous process guided by genetic, epigenetic and environmental factors, characterizing many types of somatic cells. It has been suggested as an aging hallmark that is believed to contribute to aging and chronic diseases.
Lagoumtzi, Sofia M, Chondrogianni, Niki
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Senomorphic, senolytic, and rejuvenation therapies
2022Xiang Yang Zhu, Lilach O. Lerman
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HYDROCHLOROTHIAZIDE AS A NEW SENOMORPHIC DRUG CANDIDATE
Amaç: Konvansiyonel kanser tedavisinde kullanılan kemoterapötiklerin hem kanser hem de kanser olmayan hücrelerde hücresel senesensi indüklediği bilinmektedir. Senesent hücrelerin önemli özellikleri, hücre morfolojilerinde belirgin değişikliklerin olması ve bu hücrelerden senesens ilişkili sekretuvar fenotip (SASP) olarak adlandırılan çeşitli sitokin ...Şimay Demir, Yaprak Dilber +1 more
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Advanced Materials
AbstractSenescence plays a critical role in the development and progression of various diseases. This study introduces an amorphous, high‐entropy alloy (HEA)‐based nanozyme designed to combat senescence. By adjusting the nanozyme's composition and surface properties, this work analyzes its catalytic performance under both normal and aging conditions ...
Chengjin Ding +9 more
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AbstractSenescence plays a critical role in the development and progression of various diseases. This study introduces an amorphous, high‐entropy alloy (HEA)‐based nanozyme designed to combat senescence. By adjusting the nanozyme's composition and surface properties, this work analyzes its catalytic performance under both normal and aging conditions ...
Chengjin Ding +9 more
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Journal of the American Society of Nephrology, 2023
Giuseppe Castellano +5 more
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Giuseppe Castellano +5 more
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