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Mitochondria-targeted senotherapeutic interventions
Biogerontology, 2022Healthy aging is the art of balancing a delicate scale. On one side of the scale, there are the factors that make life difficult with aging, and on the other side are the products of human effort against these factors. The most important factors that make the life difficult with aging are age-related disorders. Developing senotherapeutic strategies may
Mehmet Can Atayik, Ufuk Çakatay
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Recent Advances in Senotherapeutics Delivery
Tissue Engineering Part B: Reviews, 2022Accumulation of senescent cells (SnCs) in various tissue types has been connected to an occurrence of different age-related diseases that are indicated by its own tissue-specific hallmarks. Discovery of novel senolytic compounds that target major cellular mechanisms to inhibit the level of SnCs within the specific tissues or organs has been an emerging
Ji Young Choi +4 more
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Senotherapeutics and HIV-1 Persistence
Current HIV/AIDS Reports, 2020To review the potential use of senotherapeutics, pharmacologic agents that target senescent cells, in addressing HIV-1 persistence.Treated HIV-1 infection results in a state of immune exhaustion, which may involve reprogramming of infected and bystander cells toward a state of cellular senescence.
Matthew A, Szaniawski, Adam M, Spivak
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Senotherapeutics for mesenchymal stem cell senescence and rejuvenation
Drug Discovery Today, 2023Mesenchymal stem cells (MSCs) are susceptible to replicative senescence and senescence-associated functional decline, which hampers their use in regenerative medicine. Senotherapeutics are drugs that target cellular senescence through senolytic and senomorphic functions to induce apoptosis and suppress chronic inflammation caused by the senescence ...
Wong, Pooi Fong +2 more
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Cellular Senescence in Human Skin Aging: Leveraging Senotherapeutics
Gerontology, 2023Background: As the largest organ in the human body, the skin is continuously exposed to intrinsic and extrinsic stimuli that impact its functionality and morphology with aging. Skin aging entails dysregulation of skin cells and loss, fragmentation, or fragility of extracellular matrix fibers that are manifested macroscopically by wrinkling, laxity, and
Saranya P, Wyles +7 more
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Marine phycocompound screening reveals a potential source of novel senotherapeutics
Journal of Biomolecular Structure and Dynamics, 2021Cells undergo a controlled and systematic cycle of growth, replication and death. However, the integrity of this process gradually declines, leading to accumulation of senescent cells, a major hallmark of biological ageing. Dietary algae, particularly marine algae, have been long reported to exert anti-ageing benefits as cosmeceuticals and ...
Rahagir Salekeen +6 more
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Stem cell-derived extracellular vesicles as senotherapeutics
Ageing Research ReviewsCellular senescence (CS) is recognized as one of the hallmarks of aging, and an important player in a variety of age-related pathologies. Accumulation of senescent cells can promote a pro-inflammatory and pro-cancerogenic microenvironment. Among potential senotherapeutics are extracellular vesicles (EVs) (40-1000 nm), including exosomes (40-150 nm ...
Ekaterina, Rudnitsky +6 more
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Osteoarthritis in time for senotherapeutics
Joint Bone Spine, 2021Damien, Veret +2 more
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Cellular parabioisis as a senotherapeutic approach
Beyond cell death and differentiation, cell senescence is profoundly influenced by the social nature of cells, which is intricately linked to cell communication as a fundamental aspect of biological systems shaping both individual and collective cellular behaviors.Sencan, Sevide, Onaran, Ilhan
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