Results 1 to 10 of about 1,771 (130)

From Orange to Oncology: Anti-Inflammatory and Anti-Cancer Mechanisms of Sinensetin [PDF]

Cells
Sinensetin, a polymethoxylated flavone abundant in citrus fruits, has been recognized for its broad biological activities and wide use in traditional medicine around the world. Emerging clinical evidence from flavonoid-enriched orange juice interventions
Dong Joon Kim, Songyeon Ahn, Xiaomeng Xie, Yeon-Sun Seong, Yong Weon Yi   +4 more
doaj   +2 more sources

Effect of Media Variation on the Induction and Phytochemical Profile of Callus in Two Varieties of Cat's Whiskers (Orthosiphon aristatus Blume Miq) [PDF]

Hayati Journal of Biosciences, 2022
The levels of rosmarinic acid and sinensetin in purple and white-purple varieties of Orthosiphon aristatus, cat's whiskers, can be increased using modified in vitro culture. This work focused on callus induction of the purple and white-purple variety of
Fahrauk Faramayuda, Akhirul Kahfi Syam, Totik Sri Mariani, Elfahmi, Sukrasno   +4 more
doaj   +3 more sources

HPLC and Anti-Inflammatory Studies of the Flavonoid Rich Chloroform Extract Fraction of Orthosiphon Stamineus Leaves [PDF]

Molecules, 2010
The aim of the present study was to verify the anti-inflammatory activity of Orthosiphon stamineus leaf extracts and to identify the active compound(s) contributing to its anti-inflammatory activity using a developed HPLC method.
Mun Fei Yam, Vuanghao Lim, Ibrahim Muhammad Salman, Omar Ziad Ameer, Lee Fung Ang, Noersal Rosidah, Muthanna Fawzy Abdulkarim, Ghassan Zuhair Abdullah, Rusliza Basir, Amirin Sadikun, Mohd Zaini Asmawi   +10 more
doaj   +4 more sources

Citrus flavonoids for overcoming breast cancer resistance to methotrexate: identification of potential targets of nobiletin and sinensetin [PDF]

Discover Oncology
Breast cancer is a potentially fatal illness that affects millions of women worldwide. Methotrexate (MTX) may be beneficial for treating breast cancer; however, high doses and prolonged use can cause drug resistance.
Adam Hermawan, Naufa Hanif, Dyaningtyas Dewi Pamungkas Putri, Nurul Fatimah, Heri Himawan Prasetio   +4 more
doaj   +2 more sources

Sinensetin attenuates hepatic ischemia-reperfusion injury through suppressing GRP78/CHOP-mediated endoplasmic reticulum (ER) stress in mice [PDF]

Frontiers in Pharmacology
ObjectiveHepatic ischemia-reperfusion injury (HIRI) frequently occurs as a complication in liver surgeries, which significantly impacting patient outcomes.
Yihong Yang, Guanghua Xiong, Huangqi Shi, Yulin Peng, Jinghong Liu, Yaxuan Jiang, Min Lu, Hongbo Liu, Yong Liu   +8 more
doaj   +2 more sources

Bioguided Identification of Polymethoxyflavones as Novel Vascular Ca_V1.2 Channel Blockers from Citrus Peel [PDF]

Molecules
The huge amount of citrus peel produced worldwide represents an economic burden for society. However, this agricultural by-product is a rich source of natural molecules, potentially endowed with interesting pharmacological activities.
Anna Ramunno, Rosa Maria Vitale, Pietro Amodeo, Carlo Crescenzi, Alice Panti, Paolo Fiorenzani, Michele De Luca, Umile Gianfranco Spizzirri, Donatella Restuccia, Francesca Aiello, Fabio Fusi   +10 more
doaj   +2 more sources

Effect Balance of Bokashi and Inorganic Fertilizer on Growth, Simplicia Yield, and Content Of Sinensetin of Kumis Kucing (Orthosiphon aristatus (Blume) Miq.) [PDF]

Sains Tanah: Journal of Soil Science and Agroclimatology, 2019
Growth potential, simplicia yields, and secondary metabolites of sinensetin varieties kumis kucing can be increased through fertilization management. The aim of this research was to examine the effect balance of bokashi and inorganic fertilizer on growth,
Yoviana Erdhika Adiarti, Bambang Pujiasmanto, Widyatmani Sih Dewi   +2 more
doaj   +3 more sources

“Drying effect” of fructus aurantii components and the mechanism of action based on network pharmacology and in vitro pharmacodynamic validation [PDF]

Frontiers in Pharmacology, 2023
Background: Fructus aurantii (FA) is the dried, unripe fruit of the plant Citrus aurantium L. and its cultivated varieties. We investigated the drying effect of FA components and how this drying affect is achieved.Methods: We employed systems ...
Jing Zhu, Yi Luo, Hengli Tong, Lingyun Zhong, Qianfeng Gong, Yaqi Wang, Ming Yang, Qing Song   +7 more
doaj   +2 more sources

Sinensetin serves as an AMPK activator to inhibit RANKL-induced osteoclastogenesis via osteoclast cytoskeleton reorganization [PDF]

Journal of Translational Medicine
Osteoporosis is a skeletal condition caused by an excess of osteoclasts, resulting in an imbalance in bone metabolism. Sinensetin (SIN), one of the main ingredients in citrus fruits, provides a variety of pharmacological properties, like antioxidant, but
Yijie Gao, Rui Zhou, Xixi Lin, Zhijuan Liu, Yuangang Su, Haoyu Lian, Bin Lin, Xiaofei Ding, Shijie Liao, Xiangde Li, Jinmin Zhao, Jiake Xu, Ren Xu, Qian Liu, Fangming Song   +14 more
doaj   +2 more sources

Utilizing network pharmacology and other tools to examine active components and mechanism of action of Magnolia officinalis rheum rhabarbarum decoction in treating Streptococcus pyogenes skin infections [PDF]

Bioresources and Bioprocessing
Infections caused by Streptococcus pyogenes and the growing threat of antibiotic resistance pose significant global health challenges. This study investigates the antibacterial properties of Magnolia officinalis Rheum rhabarbarum Decoction against ...
Yuanhao Wang, Xinrui Wang, Xueying Zhang, Mengyi Pan, Mingyang Sun, Zhiguo chen, Yingli Song   +6 more
doaj   +2 more sources