Sinensetin: An Insight on Its Pharmacological Activities, Mechanisms of Action and Toxicity [PDF]
Frontiers in Pharmacology, 2021 Sinensetin, a plant-derived polymethoxylated flavonoid found in Orthosiphon aristatus var. aristatus and several citrus fruits, has been found to possess strong anticancer activities and a variety of other pharmacological benefits and promising potency ...
Lee Han Jie +4 more
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Sinensetin protects against periodontitis through binding to Bach1 enhancing its ubiquitination degradation and improving oxidative stress [PDF]
International Journal of Oral SciencePeriodontitis is a chronic inflammatory and immune reactive disease induced by the subgingival biofilm. The therapeutic effect for susceptible patients is often unsatisfactory due to excessive inflammatory response and oxidative stress.
Zhiyao Yuan +8 more
doaj +4 more sources
Isolasi Sinensetin dari Kumis Kucing (Orthosiphon aristatus Blume miq.) Varietas Putih [PDF]
JPSCR: Journal of Pharmaceutical Science and Clinical Research, 2021 Kumis kucing mengandung metabolit sekunder sinensetin yang termasuk ke dalam golongan senyawa flavonoid. Sinensetin berpotensi sebagai agen antivirus dan imunomodulator.
Fahrauk Faramayuda +5 more
doaj +2 more sources
Sinensetin suppresses influenza a virus-triggered inflammation through inhibition of NF-κB and MAPKs signalings [PDF]
BMC Complementary Medicine and Therapies, 2020 Background Human respiratory system infected with influenza A virus (IAV) elicited a robust pro-inflammatory response that resulted in severe illness and even death.
Jiashun Li +7 more
doaj +3 more sources
The Potential Role of Rosmarinic Acid and Sinensetin as α-Amylase Inhibitor: In Silico Study [PDF]
Journal of Pure and Applied Chemistry Research, 2019 The study of natural compound as α-amylase inhibitor has been a concern since the synthetic drugs for the management of type 2 diabetes mellitus have several side effects.
Hazna Noor Meidinna +1 more
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Sinensetin-Rich Fraction Solid Dispersion Inhibits Cancer Cell Cycle [PDF]
KnE Life Sciences, 2017 Drug development efforts to find new selective and safe drugs for cancer from natural resources are promising ones. The natural products are obtained in the multiple or single compounds. One of them is a sinensetin found in ethanol extract of Orthosiphon
Arifianti, Lusiana +2 more
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Sinensetin regulates age-related sarcopenia in cultured primary thigh and calf muscle cells [PDF]
BMC Complementary and Alternative Medicine, 2019 Background Sarcopenia, the decline of skeletal muscle tissue attributed to primary aging is a major concern in older adults. Flavonoids might have potential benefits by modulating the regulation of satellite cells, thus preventing muscle loss. Sinensetin
Jin-A Kim +6 more
doaj +3 more sources
Indonesian Journal of Chemistry, 2012 Sinensetin-like molecules have been searched virtually to find a dummy template for Molecular Imprinted Polymer (MIP) synthesis. The aim of this study is to find a novel adsorbent for Solid Phase Extraction (SPE) of sinensetin based on tailored method ...
Iqmal Tahir +3 more
doaj +4 more sources
Enhancement and optimization of sinensetin extract from orthosiphon stamineus using supercrtitical carbon dioxide extraction [PDF]
Malaysian Journal of Analytical Science, 2018 Sinensetin is a rare valuable flavonoid compound that contains 5 methoxy groups attached on the flavone backbone. This compound is abundantly established in citrus peel and can also be found in medicinal herb, ‘misai kucing’.
Abdul Aziz, Ahmad Hazim +6 more
core +3 more sources
Sinensetin Attenuated Macrophagic NLRP3 Inflammasomes Formation via SIRT1-NRF2 Signaling
ACS Omega, 2023 Macrophage-mediated inflammation plays essential roles in multiple-organ injury. Sinensetin (SNS) at least exhibits anti-inflammation, antioxidant, and antitumor properties. However, the underlying mechanism of SNS-targeted macrophage-mediated inflammation remains elusive. In the present study, our results showed that SNS suppressed lipopolysaccharide (
Lin Lin +5 more
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