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MicroRNA-221-3p targets ESR1 and downregulates SLC7A11 to exacerbate hypoxia/reoxygenation-induced cardiomyocyte injury. [PDF]
Ye J, Xia H, Liu M, Yu L, Liu L.
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Protective Effect of Chinese Herbal Medicine on Cerebral Ischemia-Reperfusion Injury by Regulating Ferroptosis. [PDF]
Luo S, Zhu J, Yang L, Liu J, Deng Y.
europepmc +1 more source
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SLC7A11/xCT Prevents Cardiac Hypertrophy by Inhibiting Ferroptosis
Cardiovascular Drugs and Therapy, 2021Systemic hypertension may induce adverse hypertrophy of the left cardiac ventricle. Pathological cardiac hypertrophy is a common cause of heart failure. We investigated the significance of ferroptosis repressor xCT in hypertrophic cardiomyopathy.xCT expression in angiotensin II (Ang II)-treated mouse hearts and rat cardiomyocytes was determined using ...
Xiyu, Zhang +11 more
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xCT/SLC7A11 antiporter function inhibits HIV-1 infection
Virology, 2021Human macrophages are protected by intrinsic antiviral defenses that provide moderate protection against HIV-1 infection. Macrophages that do become infected can serve as long-lived reservoirs, to disseminate HIV-1 to CD4+ T cells. Infection of macrophages with HIV-1 and HIV-2 is inhibited by constitutive mobilization of antioxidant response master ...
Jesse Rabinowitz +7 more
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Die Pharmazie, 2017
Antisense lncRNAs play a key role in the progression of multiple cancers. Thus, it is important to elucidate the function and mechanism of antisense lncRNAs, which may play a role in the treatment of epithelial ovarian cancer (EOC). In the current study, for the first time, we showed that the level of As-SLC7A11 was markedly reduced in EOC cancer ...
Jinjin Yuan, Jinjin Yuan +2 more
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Antisense lncRNAs play a key role in the progression of multiple cancers. Thus, it is important to elucidate the function and mechanism of antisense lncRNAs, which may play a role in the treatment of epithelial ovarian cancer (EOC). In the current study, for the first time, we showed that the level of As-SLC7A11 was markedly reduced in EOC cancer ...
Jinjin Yuan, Jinjin Yuan +2 more
openaire +2 more sources

