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SLC7A11/xCT Prevents Cardiac Hypertrophy by Inhibiting Ferroptosis

Cardiovascular Drugs and Therapy, 2021
Systemic hypertension may induce adverse hypertrophy of the left cardiac ventricle. Pathological cardiac hypertrophy is a common cause of heart failure. We investigated the significance of ferroptosis repressor xCT in hypertrophic cardiomyopathy.xCT expression in angiotensin II (Ang II)-treated mouse hearts and rat cardiomyocytes was determined using ...
Xiyu, Zhang   +11 more
openaire   +2 more sources

xCT/SLC7A11 antiporter function inhibits HIV-1 infection

Virology, 2021
Human macrophages are protected by intrinsic antiviral defenses that provide moderate protection against HIV-1 infection. Macrophages that do become infected can serve as long-lived reservoirs, to disseminate HIV-1 to CD4+ T cells. Infection of macrophages with HIV-1 and HIV-2 is inhibited by constitutive mobilization of antioxidant response master ...
Jesse Rabinowitz   +7 more
openaire   +2 more sources

Antisense lncRNA As-SLC7A11 suppresses epithelial ovarian cancer progression mainly by targeting SLC7A11.

Die Pharmazie, 2017
Antisense lncRNAs play a key role in the progression of multiple cancers. Thus, it is important to elucidate the function and mechanism of antisense lncRNAs, which may play a role in the treatment of epithelial ovarian cancer (EOC). In the current study, for the first time, we showed that the level of As-SLC7A11 was markedly reduced in EOC cancer ...
Jinjin Yuan, Jinjin Yuan   +2 more
openaire   +2 more sources

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