Proteinuric Kidney Diseases: A Podocyte's Slit Diaphragm and Cytoskeleton Approach [PDF]
Frontiers in Medicine, 2018 Proteinuric kidney diseases are a group of disorders with diverse pathological mechanisms associated with significant losses of protein in the urine.
Samuel Mon-Wei Yu +4 more
doaj +5 more sources
A novel in vivo method to quantify slit diaphragm protein abundance in murine proteinuric kidney disease. [PDF]
PLoS ONE, 2017 Injury of the glomerular filter causes proteinuria by disrupting the sensitive interplay of the glomerular protein network. To date, studies of the expression and trafficking of glomerular proteins have been mostly limited to in vitro or histologic ...
Raphael Haase +11 more
doaj +2 more sources
Organoids from Nephrotic Disease-Derived iPSCs Identify Impaired NEPHRIN Localization and Slit Diaphragm Formation in Kidney Podocytes [PDF]
Stem Cell Reports, 2018 Summary: Mutations in the NPHS1 gene, which encodes NEPHRIN, cause congenital nephrotic syndrome, resulting from impaired slit diaphragm (SD) formation in glomerular podocytes.
Shunsuke Tanigawa +13 more
doaj +2 more sources
Hypoxia decreases podocyte expression of slit diaphragm proteins
International Journal of Nephrology and Renovascular Disease, 2012 Hong Lu,1 Gaurav Kapur,1 Tej K Mattoo,1 William D Lyman1,21Carman and Ann Adams Department of Pediatrics, 2Children's Research Center of Michigan, Children's Hospital of Michigan, Detroit, MI, USABackground: Chronic hypoxia contributes to
Lu H, Kapur G, Mattoo TK, Lyman WD
doaj +6 more sources
Endocytic Trafficking at the Mature Podocyte Slit Diaphragm. [PDF]
Front Pediatr, 2017 Endocytic trafficking couples cell signaling with the cytoskeletal dynamics by organizing a crosstalk between protein networks in different subcellular compartments. Proteins residing in the plasma membrane are internalized and transported as cargo in endocytic vesicles (i.e., endocytosis). Subsequently, cargo proteins can be delivered to lysosomes for
Swiatecka-Urban A.
europepmc +4 more sources
From slit diaphragm to autoantigen formation: a SUMOylation-based perspective on minimal change disease [PDF]
Frontiers in NephrologyEmre Leventoğlu +2 more
doaj +2 more sources
Slit Diaphragms Contain Tight Junction Proteins [PDF]
Journal of the American Society of Nephrology, 2009 Slit diaphragms are essential components of the glomerular filtration apparatus, as changes in these junctions are the hallmark of proteinuric diseases. Slit diaphragms, considered specialized adherens junctions, contain both unique membrane proteins (e.g., nephrin, podocin, and Neph1) and typical adherens junction proteins (e.g., P-cadherin, FAT, and ...
Hirotaka, Fukasawa +3 more
openaire +2 more sources
In vivo characterization of a podocyte-expressed short podocin isoform
BMC Nephrology, 2023 The most common genetic causes of steroid-resistant nephrotic syndrome (SRNS) are mutations in the NPHS2 gene, which encodes the cholesterol-binding, lipid-raft associated protein podocin. Mass spectrometry and cDNA sequencing revealed the existence of a
Linus Butt +8 more
doaj +1 more source
A novel domain regulating degradation of the glomerular slit diaphragm protein podocin in cell culture systems. [PDF]
PLoS ONE, 2013 Mutations in the gene NPHS2 are the most common cause of hereditary steroid-resistant nephrotic syndrome. Its gene product, the stomatin family member protein podocin represents a core component of the slit diaphragm, a unique structure that bridges the ...
Markus Gödel +4 more
doaj +1 more source
Wtip- and gadd45a-interacting protein dendrin is not crucial for the development or maintenance of the glomerular filtration barrier. [PDF]
PLoS ONE, 2013 Glomerular podocyte cells are critical for the function of the renal ultrafiltration barrier. Especially, the highly specialized cell-cell junction of podocytes, the slit diaphragm, has a central role in the filtration barrier. This is highlighted by the
Zhijie Xiao +5 more
doaj +1 more source