Results 11 to 20 of about 217,308 (243)

Linking Basement Membrane and Slit Diaphragm in Drosophila Nephrocytes. [PDF]

J Am Soc Nephrol
Visual Abstract Key Points Drosophila nephrocytes feature a special basement membrane that may serve to model joint function of the glomerular filtration barrier.
Leroy C, Lang K, Spitz D, Milosavljevic J, Heinkele H, Kayser S, Helmstädter M, Walz G, Ulbrich MH, Hermle T.   +9 more
europepmc   +5 more sources

Piezo, Nephrocyte Function, and Slit Diaphragm Maintenance in Drosophila.

J Am Soc Nephrol
Visual Abstract Key Points Piezo channels, known for detecting mechanical pressure, were found to be expressed at the lacuna channel membranes of nephrocytes.
Zhao Y, Duan J, Han ID, van de Leemput J, Ray PE, Han Z.   +5 more
europepmc   +4 more sources

Endocytic Trafficking at the Mature Podocyte Slit Diaphragm. [PDF]

Front Pediatr, 2017
Endocytic trafficking couples cell signaling with the cytoskeletal dynamics by organizing a crosstalk between protein networks in different subcellular compartments.
Swiatecka-Urban A.
europepmc   +5 more sources

Selective endocytosis controls slit diaphragm maintenance and dynamics in Drosophila nephrocytes. [PDF]

Elife, 2022
The kidneys generate about 180 l of primary urine per day by filtration of plasma. An essential part of the filtration barrier is the slit diaphragm, a multiprotein complex containing nephrin as major component.
Lang K, Milosavljevic J, Heinkele H, Chen M, Gerstner L, Spitz D, Kayser S, Helmstädter M, Walz G, Köttgen M, Spracklen A, Poulton J, Hermle T.   +12 more
europepmc   +2 more sources

Mechanotransduction and the Integrity of the Slit Diaphragm.

J Am Soc Nephrol
Hill RZ.
europepmc   +4 more sources

WWC1 promotes podocyte survival via stabilizing slit diaphragm protein dendrin. [PDF]

Mol Med Rep, 2017
Previous studies have indicated that glomerular podocyte injury serves a crucial role in proteinuria during the process of chronic kidney disease. The slit diaphragm of podocytes forms the final barrier to proteinuria.
Lin T, Zhang L, Liu S, Chen Y, Zhang H, Zhao X, Li R, Zhang Q, Liao R, Huang Z, Zhang B, Wang W, Liang X, Shi W.   +13 more
europepmc   +5 more sources

Using Drosophila Nephrocytes to Understand the Formation and Maintenance of the Podocyte Slit Diaphragm. [PDF]

Front Cell Dev Biol, 2022
The podocyte slit diaphragm (SD) is an essential component of the glomerular filtration barrier and its disruption is a common cause of proteinuria and many types of kidney disease.
van de Leemput J, Wen P, Han Z.
europepmc   +2 more sources

Activation of Hippo Pathway Damages Slit Diaphragm by Deprivation of Ajuba Proteins.

J Am Soc Nephrol, 2023
Significance Statement Nuclear exclusion of the cotranscription factor YAP, which is a consequence of activation of the Hippo signaling pathway, leads to FSGS and podocyte apoptosis.
Gilhaus K, Cepok C, Kamm D, Surmann B, Nedvetsky PI, Emich J, Sundukova A, Saatkamp K, Nüsse H, Klingauf J, Wennmann DO, George B, Krahn MP, Pavenstädt HJ, Vollenbröker BA.   +14 more
europepmc   +2 more sources

An acytokinetic cell division creates PIP2-enriched membrane asymmetries leading to slit diaphragm assembly in Drosophila nephrocytes.

Development, 2023
Vertebrate podocytes and Drosophila nephrocytes display slit diaphragms, specialised cell junctions that are essential for the execution of the basic excretory function of ultrafiltration.
Carrasco-Rando M, Culi J, Campuzano S, Ruiz-Gómez M.   +3 more
europepmc   +2 more sources

PI(4,5)P2 controls slit diaphragm formation and endocytosis in Drosophila nephrocytes. [PDF]

Cell Mol Life Sci, 2022
Drosophila nephrocytes are an emerging model system for mammalian podocytes and proximal tubules as well as for the investigation of kidney diseases. Like podocytes, nephrocytes exhibit characteristics of epithelial cells, but the role of phospholipids ...
Gass MM, Borkowsky S, Lotz ML, Siwek R, Schröter R, Nedvetsky P, Luschnig S, Rohlmann A, Missler M, Krahn MP.   +9 more
europepmc   +2 more sources