Role of Protein Kinase C (PKC) in Podocytes and Development of Glomerular Damage in Diabetic Nephropathy [PDF]
Frontiers in Endocrinology, 2014 The early glomerular changes in diabetes include a podocyte phenotype with loss of slit diaphragm proteins, changes in the actin cytoskeleton and foot process architecture.
Beina eTeng +4 more
doaj +3 more sources
Phosphorylation of slit diaphragm proteins NEPHRIN and NEPH1 upon binding of HGF promotes podocyte repair. [PDF]
J Biol Chem, 2021 Phosphorylation (activation) and dephosphorylation (deactivation) of the slit diaphragm proteins NEPHRIN and NEPH1 are critical for maintaining the kidney epithelial podocyte actin cytoskeleton and, therefore, proper glomerular filtration.
Solanki AK +15 more
europepmc +2 more sources
Apical-basal polarity regulators are essential for slit diaphragm assembly and endocytosis in Drosophila nephrocytes. [PDF]
Cell Mol Life Sci, 2021 Apical-basal polarity is a key feature of most epithelial cells and it is regulated by highly conserved protein complexes. In mammalian podocytes, which emerge from columnar epithelial cells, this polarity is preserved and the tight junctions are ...
Heiden S +8 more
europepmc +2 more sources
Crumbs2 Is an Essential Slit Diaphragm Protein of the Renal Filtration Barrier.
J Am Soc Nephrol, 2021 Visual Abstract Significance Statement Mutations in the Crumbs2 (CRB2) gene were recently identified as a cause of steroid-resistant nephrotic syndrome (SRNS), but it is unknown how Crumbs2 dysfunction damages the glomerular filtration barrier (GFB ...
Möller-Kerutt A +11 more
europepmc +2 more sources
New insight into podocyte slit diaphragm, a therapeutic target of proteinuria. [PDF]
Clin Exp Nephrol, 2020 Dysfunction of slit diaphragm, a cell–cell junction of glomerular podocytes, is involved in the development of proteinuria in several glomerular diseases. Slit diaphragm should be a target of a novel therapy for proteinuria.
Kawachi H, Fukusumi Y.
europepmc +2 more sources
Endocytosis mediated by an atypical CUBAM complex modulates slit diaphragm dynamics in nephrocytes.
Development, 2021 The vertebrate endocytic receptor CUBAM, consisting of three cubilin monomers complexed with a single amnionless molecule, plays a major role in protein reabsorption in the renal proximal tubule.
Atienza-Manuel A +4 more
europepmc +2 more sources
J Am Soc Nephrol, 2021 Visual Abstract Significance Statement Slit diaphragms between podocytes play a critical role in maintaining the filtration function in kidney. At each slit diaphragm there is an electron-dense junctional plaque crucial for slit diaphragm integrity and ...
Zhang H +9 more
europepmc +2 more sources
J Am Soc Nephrol, 2021 Significance Statement Apical polarity proteins are key regulators of podocyte function, particularly with respect to slit diaphragm (SD) integrity. However, no experimental evidence demonstrates basolateral polarity proteins regulate SDs, suggesting ...
Mysh M, Poulton JS.
europepmc +2 more sources
Selective endocytosis controls slit diaphragm maintenance and dynamics in Drosophila nephrocytes [PDF]
bioRxiv, 2022 The kidneys generate about 180 liters of primary urine per day by filtration of plasma. An essential part of the filtration barrier is the slit diaphragm, a multiprotein complex containing nephrin as major component.
Konrad Lang +12 more
semanticscholar +2 more sources
The molecular architecture of the kidney slit diaphragm
bioRxiv, 2023 Vertebrate life depends on renal function to filter excess fluid and remove low-molecular-weight waste products. An essential component of the kidney filtration barrier is the slit diaphragm (SD), a specialized cell-cell junction between podocytes ...
Alexandra N. Birtasu +8 more
semanticscholar +2 more sources