Results 21 to 30 of about 17,762 (221)
Structural features and oligomeric nature of human podocin domain
Biochemistry and Biophysics Reports, 2020 Podocytes are crucial cells of the glomerular filtration unit and plays a vital role at the interface of the blood-urine barrier. Podocyte slit-diaphragm is a modified tight junction that facilitates size and charge-dependent permselectivity.
Sandeep K.N. Mulukala +6 more
doaj +1 more source
, 2022 A quantum model of Fraunhofer diffraction by an aperture is presented. The diaphragm is considered as a device for measuring the three spatial coordinates of the particles passing through the aperture.
Fabbro, Bernard
core +2 more sources
Linking Basement Membrane and Slit Diaphragm in Drosophila Nephrocytes.
J Am Soc NephrolKey Points Drosophila nephrocytes feature a special basement membrane that may serve to model joint function of the glomerular filtration barrier.Silencing of Drosophila laminin and collagen IV genes reduced the density of slit diaphragms in ...
Leroy C +9 more
europepmc +4 more sources
Sensitizing the Slit Diaphragm with TRPC6 Ion Channels [PDF]
Journal of the American Society of Nephrology, 2009 Physiologic permeability of the glomerular capillary depends on the normal structure of podocyte foot processes forming a functioning slit diaphragm in between. Mutations in several podocyte genes as well as specific molecular pathways have been identified as the cause for progressive kidney failure with urinary protein loss.
Clemens C, Möller +2 more
openaire +2 more sources
FAT is a component of glomerular slit diaphragms [PDF]
Kidney International, 2001 Slit diaphragms are intercellular junctions of podocytes of the renal glomerulus. The molecular composition of slit diaphragms is still elusive. Slit diaphragms are characterized by the presence of a wide intercellular space. The morphological feature is shared by desmosomes and adherens junctions, which contain members of the cadherin superfamily ...
Inoue, Tsutomu +11 more
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Identification of a putative network of actin-associated cytoskeletal proteins in glomerular podocytes defined by co-purified mRNAs. [PDF]
PLoS ONE, 2009 The glomerular podocyte is a highly specialized and polarized kidney cell type that contains major processes and foot processes that extend from the cell body.
Behnam Nabet +3 more
doaj +1 more source
Optimized background suppression in near field lidar telescopes [PDF]
, 2003 It is shown that a tilted slit in the focal plane of the lidar telescope limits the telescopes field of view efficiently and suppresses the background in the lidar signal by up to an order of magnitude better than a circular ...
Freudenthaler, Volker
core +1 more source
Signaling at the Slit Diaphragm [PDF]
Journal of the American Society of Nephrology, 2004 Diseases of the glomerular filter of the kidney are a leading cause of end-stage renal failure. Recent studies have emphasized the critical role of the slit diaphragm of podocytes for the size-selective filtration barrier of the kidney and revealed novel aspects of the mechanisms that lead ...
openaire +3 more sources
The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm. [PDF]
, 2008 The nephron is the basic structural and functional unit of the vertebrate kidney. It is composed of a glomerulus, the site of ultrafiltration, and a renal tubule, along which the filtrate is modified. Although widely regarded as a vertebrate adaptation, '
Bader, Augustinus +16 more
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Slit Diaphragm Protein Neph1 and Its Signaling [PDF]
Journal of Biological Chemistry, 2014 Podocytes are specialized epithelial cells that are critical components of the glomerular filtration barrier, and their dysfunction leads to proteinuria and renal failure. Therefore, preserving podocyte function is therapeutically significant. In this study, we identified Neph1 signaling as a therapeutic target that upon inhibition prevented podocyte ...
Ehtesham Arif +6 more
openaire +1 more source