Results 31 to 40 of about 217,308 (243)

A novel in vivo method to quantify slit diaphragm protein abundance in murine proteinuric kidney disease. [PDF]

PLoS One, 2017
Injury of the glomerular filter causes proteinuria by disrupting the sensitive interplay of the glomerular protein network. To date, studies of the expression and trafficking of glomerular proteins have been mostly limited to in vitro or histologic ...
Haase R, Potthoff SA, Meyer-Schwesinger C, Frosch C, Wiech T, Panzer U, Königshausen E, Stegbauer J, Sellin L, Rump LC, Quack I, Woznowski M.   +11 more
europepmc   +2 more sources

Exocyst Genes Are Essential for Recycling Membrane Proteins and Maintaining Slit Diaphragm in Drosophila Nephrocytes.

J Am Soc Nephrol, 2020
BACKGROUND Studies have linked mutations in genes encoding the eight-protein exocyst protein complex to kidney disease, but the underlying mechanism is unclear.
Wen P, Zhang F, Fu Y, Zhu JY, Han Z.
europepmc   +2 more sources

Mutations in KIRREL1, a slit diaphragm component, cause steroid-resistant nephrotic syndrome. [PDF]

Kidney Int, 2019
Steroid-resistant nephrotic syndrome is a frequent cause of chronic kidney disease almost inevitably progressing to end-stage renal disease. More than 58 monogenic causes of SRNS have been discovered and majority of known steroid-resistant nephrotic ...
Solanki AK, Widmeier E, Arif E, Sharma S, Daga A, Srivastava P, Kwon SH, Hugo H, Nakayama M, Mann N, Majmundar AJ, Tan W, Gee HY, Sadowski CE, Rinat C, Becker-Cohen R, Bergmann C, Rosen S, Somers M, Shril S, Huber TB, Mane S, Hildebrandt F, Nihalani D.   +23 more
europepmc   +2 more sources

Nephrin Signaling in the Podocyte: An Updated View of Signal Regulation at the Slit Diaphragm and Beyond. [PDF]

Front Endocrinol (Lausanne), 2018
Podocytes are a major component of the glomerular blood filtration barrier, and alterations to the morphology of their unique actin-based foot processes (FP) are a common feature of kidney disease. Adjacent FP are connected by a specialized intercellular
Martin CE, Jones N.
europepmc   +2 more sources

Kidney Injury by Variants in the COL4A5 Gene Aggravated by Polymorphisms in Slit Diaphragm Genes Causes Focal Segmental Glomerulosclerosis. [PDF]

Int J Mol Sci, 2019
Kidney injury due to focal segmental glomerulosclerosis (FSGS) is the most common primary glomerular disorder causing end-stage renal disease. Homozygous mutations in either glomerular basement membrane or slit diaphragm genes cause early renal failure ...
Frese J, Kettwig M, Zappel H, Hofer J, Gröne HJ, Nagel M, Sunder-Plassmann G, Kain R, Neuweiler J, Gross O.   +9 more
europepmc   +2 more sources

Hypoxia decreases podocyte expression of slit diaphragm proteins

International Journal of Nephrology and Renovascular Disease, 2012
Hong Lu,1 Gaurav Kapur,1 Tej K Mattoo,1 William D Lyman1,21Carman and Ann Adams Department of Pediatrics, 2Children's Research Center of Michigan, Children's Hospital of Michigan, Detroit, MI, USABackground: Chronic hypoxia contributes to
Lu H, Kapur G, Mattoo TK, Lyman WD
doaj   +6 more sources

The human nephrin Y¹¹³⁹RSL motif is essential for podocyte foot process organization and slit diaphragm formation during glomerular development. [PDF]

J Biol Chem, 2019
Nephrin is an immunoglobulin-type cell-adhesion molecule with a key role in the glomerular interpodocyte slit diaphragm. Mutations in the nephrin gene are associated with defects in the slit diaphragm, leading to early-onset nephrotic syndrome, typically
Espiritu EB, Jiang H, Moreau-Marquis S, Sullivan M, Yan K, Beer Stolz D, Sampson MG, Hukriede NA, Swiatecka-Urban A.   +8 more
europepmc   +2 more sources

Thrombospondin Type 1 Domain-Containing 7A Localizes to the Slit Diaphragm and Stabilizes Membrane Dynamics of Fully Differentiated Podocytes.

J Am Soc Nephrol, 2019
BACKGROUND About 3%-5% of adults with membranous nephropathy have autoantibodies directed against thrombospondin type 1 domain-containing 7A (THSD7A), a podocyte-expressed transmembrane protein.
Herwig J, Skuza S, Sachs W, Sachs M, Failla AV, Rune G, Meyer TN, Fester L, Meyer-Schwesinger C.   +8 more
europepmc   +2 more sources

Tyrosine Phosphorylation of CD2AP Affects Stability of the Slit Diaphragm Complex.

J Am Soc Nephrol, 2019
BACKGROUND CD2-associated protein (CD2AP), a slit diaphragm-associated scaffolding protein involved in survival and regulation of the cytoskeleton in podocytes, is considered a "stabilizer" of the slit diaphragm complex that connects the slit diaphragm ...
Tossidou I, Teng B, Worthmann K, Müller-Deile J, Jobst-Schwan T, Kardinal C, Schroder P, Bolanos-Palmieri P, Haller H, Willerding J, Drost DM, de Jonge L, Reubold T, Eschenburg S, Johnson RI, Schiffer M.   +15 more
europepmc   +2 more sources

Structural Basis of Highly Specific Interaction between Nephrin and MAGI1 in Slit Diaphragm Assembly and Signaling.

J Am Soc Nephrol, 2018
BACKGROUND The slit diaphragm is a specialized adhesion junction between opposing podocytes, establishing the final filtration barrier that prevents passage of proteins from the capillary lumen into the urinary space.
Weng Z, Shang Y, Ji Z, Ye F, Lin L, Zhang R, Zhu J.   +6 more
europepmc   +2 more sources