Results 31 to 40 of about 17,762 (221)
The Kantian Framework of Complementarity [PDF]
, 2010 A growing number of commentators have, in recent years, noted the important affinities in the views of Immanuel Kant and Niels Bohr. While these commentators are correct, the picture they present of the connections between Bohr and Kant is painted in ...
Allison +37 more
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Molecular Evolution of Podocyte Slit-diaphragm Proteins [PDF]
, 2020 AbstractVertebrates kidneys contribute to the homeostasis by regulating electrolyte, acid-base balance, and prevent protein loss into the urine. Glomerular podocytes constitute blood-urine barrier and podocyte slit-diaphragm, a modified tight junction contributes to the glomerular permselectivity. Nephrin, podocin, CD2AP, and TRPC6 are considered to be
NSK Mulukala +3 more
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A new outlook towards kidney injuries [PDF]
, 2012 Acute and chronic progression of injury to the kidney leads to the failure of the renal system and has become an increasingly important cause of morbidity and mortality.
Abhijeet Satwekar, Mahesh Satwekar
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The Glomerular Slit Diaphragm Is a Modified Adherens Junction [PDF]
Journal of the American Society of Nephrology, 2000 Abstract. The glomerular slit diaphragm between podocyte foot processes shares typical morphologic features with an adherens junction. Differentiated cultured podocytes form cellular structures comparable to filtration slits in vivo. At those sites, zonula occludens-1 (ZO-1) was coexpressed with P-cadherin as well as with α-, β-
Jochen, Reiser +3 more
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Frontiers in Cell and Developmental Biology, 2023 Introduction: The unique architecture of glomerular podocytes is integral to kidney filtration. Interdigitating foot processes extend from the podocyte cell body, wrap around fenestrated capillaries, and form specialized junctional complexes termed slit ...
Gary F. Gerlach +4 more
doaj +1 more source
Renal Failure, 2023 Diabetic kidney disease (DKD) is a primary cause of end-stage renal disease. Proteinuria is a clinical indicator of the different stages of DKD, and podocyte injury is a major cause of proteinuria.
Le Gong +7 more
doaj +1 more source
Selective endocytosis controls slit diaphragm maintenance and dynamics [PDF]
, 2022 SUMMARY The kidneys generate about 180 liters of primary urine per day by filtration of plasma. An essential part of the filtration barrier is the slit diaphragm, a multiprotein complex containing nephrin as major component.
Konrad Lang +12 more
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Lipid–Protein Interactions along the Slit Diaphragm of Podocytes [PDF]
Journal of the American Society of Nephrology, 2009 Podocytes are visceral epithelial cells supporting the function of the glomerular filter. Interdigitating foot processes of podocytes enwrap the glomerular capillaries and are connected by a highly specialized cell junction, the slit diaphragm. Signal transduction at the slit diaphragm is essential for the proper function of the kidney filtration ...
Bernhard, Schermer, Thomas, Benzing
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Structural continuity of filtration slit (slit diaphragm) to plasma membrane of podocyte
Kidney International, 1996 Murine monoclonal antibody 5-1-6 was reported to bind to the slit membrane and closely related structures in rat renal glomeruli; it induced heavy, reversible proteinuria and appeared to redistribute onto the plasma membrane of epithelial cells after binding at the original target sites.
Fujigaki, Yoshihide +8 more
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Kif21a deficiency leads to impaired glomerular filtration barrier function
Scientific Reports, 2023 The renal glomerulus represents the major filtration body of the vertebrate nephron and is responsible for urine production and a number of other functions such as metabolic waste elimination and the regulation of water, electrolyte and acid–base balance.
Hanna Riedmann +4 more
doaj +1 more source