Results 41 to 50 of about 217,308 (243)
From slit diaphragm to autoantigen formation: a SUMOylation-based perspective on minimal change disease. [PDF]
Front NephrolLeventoğlu E +2 more
europepmc +2 more sources
Slit Diaphragms Contain Tight Junction Proteins [PDF]
Journal of the American Society of Nephrology, 2009 Slit diaphragms are essential components of the glomerular filtration apparatus, as changes in these junctions are the hallmark of proteinuric diseases. Slit diaphragms, considered specialized adherens junctions, contain both unique membrane proteins (e.g., nephrin, podocin, and Neph1) and typical adherens junction proteins (e.g., P-cadherin, FAT, and ...
Hirotaka, Fukasawa +3 more
openaire +2 more sources
In vivo characterization of a podocyte-expressed short podocin isoform
BMC Nephrology, 2023 The most common genetic causes of steroid-resistant nephrotic syndrome (SRNS) are mutations in the NPHS2 gene, which encodes the cholesterol-binding, lipid-raft associated protein podocin. Mass spectrometry and cDNA sequencing revealed the existence of a
Linus Butt +8 more
doaj +1 more source
A novel domain regulating degradation of the glomerular slit diaphragm protein podocin in cell culture systems. [PDF]
PLoS ONE, 2013 Mutations in the gene NPHS2 are the most common cause of hereditary steroid-resistant nephrotic syndrome. Its gene product, the stomatin family member protein podocin represents a core component of the slit diaphragm, a unique structure that bridges the ...
Markus Gödel +4 more
doaj +1 more source
Structural features and oligomeric nature of human podocin domain
Biochemistry and Biophysics Reports, 2020 Podocytes are crucial cells of the glomerular filtration unit and plays a vital role at the interface of the blood-urine barrier. Podocyte slit-diaphragm is a modified tight junction that facilitates size and charge-dependent permselectivity.
Sandeep K.N. Mulukala +6 more
doaj +1 more source
, 2022 A quantum model of Fraunhofer diffraction by an aperture is presented. The diaphragm is considered as a device for measuring the three spatial coordinates of the particles passing through the aperture.
Fabbro, Bernard
core +2 more sources
Sensitizing the Slit Diaphragm with TRPC6 Ion Channels [PDF]
Journal of the American Society of Nephrology, 2009 Physiologic permeability of the glomerular capillary depends on the normal structure of podocyte foot processes forming a functioning slit diaphragm in between. Mutations in several podocyte genes as well as specific molecular pathways have been identified as the cause for progressive kidney failure with urinary protein loss.
Clemens C, Möller +2 more
openaire +2 more sources
Diabetes, 2021 Foot process effacement is an important feature of early diabetic nephropathy (DN), which is closely related to the development of albuminuria. Under certain nephrotic conditions, the integrity and function of the glomerular slit diaphragm (SD) structure
Bin Wang +12 more
semanticscholar +1 more source
FAT is a component of glomerular slit diaphragms [PDF]
Kidney International, 2001 Slit diaphragms are intercellular junctions of podocytes of the renal glomerulus. The molecular composition of slit diaphragms is still elusive. Slit diaphragms are characterized by the presence of a wide intercellular space. The morphological feature is shared by desmosomes and adherens junctions, which contain members of the cadherin superfamily ...
Inoue, Tsutomu +11 more
openaire +2 more sources
Identification of a putative network of actin-associated cytoskeletal proteins in glomerular podocytes defined by co-purified mRNAs. [PDF]
PLoS ONE, 2009 The glomerular podocyte is a highly specialized and polarized kidney cell type that contains major processes and foot processes that extend from the cell body.
Behnam Nabet +3 more
doaj +1 more source