Results 41 to 50 of about 17,762 (221)

Current concepts of the podocyte in nephrotic syndrome

Kidney Research and Clinical Practice, 2012
Nephrotic syndrome is a disorder of the glomerular filtration barrier, and central to the filtration mechanism of the glomerular filtration barrier is the podocyte.
Wen Y. Ding, Moin A. Saleem
doaj   +1 more source

New perspectives on the renal slit diaphragm protein podocin [PDF]

Modern Pathology, 2011
Podocin is a critical component of the glomerular filtration barrier, its mutations causing recessive steroid-resistant nephrotic syndrome. A GenBank analysis of the human podocin (NPHS2) gene resulted in the possible existence of a new splice variant of podocin in the kidney, missing the in-frame of exon 5, encoding the prohibitin homology domain ...
Relle, Manfred, Cash, Hannes, Brochhausen, Christoph, Strand, Dennis, Menke, Julia, Galle, Peter R, Schwarting, Andreas   +6 more
openaire   +2 more sources

Morphine induces albuminuria by compromising podocyte integrity.

PLoS ONE, 2013
Morphine has been reported to accelerate the progression of chronic kidney disease. However, whether morphine affects slit diaphragm (SD), the major constituent of glomerular filtration barrier, is still unclear.
Xiqian Lan, Partab Rai, Nirupama Chandel, Kang Cheng, Rivka Lederman, Moin A Saleem, Peter W Mathieson, Mohammad Husain, John T Crosson, Kalpna Gupta, Ashwani Malhotra, Pravin C Singhal   +11 more
doaj   +1 more source

Genetic Basis of Steroid Resistant Nephrotic Syndrome [PDF]

Childhood Kidney Diseases, 2019
Steroid-resistant nephrotic syndrome (SRNS) has long been a challenge for clinicians due to its poor responsiveness to immunosuppressants, and rapid progression to end-stage renal disease.
Eujin Park
doaj   +1 more source

Podocytic PKC-alpha is regulated in murine and human diabetes and mediates nephrin endocytosis. [PDF]

PLoS ONE, 2010
BACKGROUND: Microalbuminuria is an early lesion during the development of diabetic nephropathy. The loss of high molecular weight proteins in the urine is usually associated with decreased expression of slit diaphragm proteins.
Irini Tossidou, Beina Teng, Jan Menne, Nelli Shushakova, Joon-Keun Park, Jan U Becker, Friedrich Modde, Michael Leitges, Hermann Haller, Mario Schiffer   +9 more
doaj   +1 more source

WWC1 promotes podocyte survival via stabilizing slit diaphragm protein dendrin. [PDF]

Mol Med Rep, 2017
Previous studies have indicated that glomerular podocyte injury serves a crucial role in proteinuria during the process of chronic kidney disease. The slit diaphragm of podocytes forms the final barrier to proteinuria. Dendrin, a constituent of the slit diaphragm protein complex, has been observed to relocate from the slit diaphragm to the nuclei in ...
Lin T, Zhang L, Liu S, Chen Y, Zhang H, Zhao X, Li R, Zhang Q, Liao R, Huang Z, Zhang B, Wang W, Liang X, Shi W.   +13 more
europepmc   +4 more sources

The number of podocyte and slit diaphragm is decreased in experimental diabetic nephropathy O número de podócitos e fendas diafragmáticas estão alterados na nefropatia diabética

Acta Cirúrgica Brasileira, 2006
PURPOSE: To determine the number of podocyte, slit diaphragms, slit diaphragm extensions and GBM thickness in diabetic nephropathy. METHODS: Sixty "Rattus Wistar"of both sexes weighing 200-300g were divided in two experimental groups: normal group 10 ...
Mauro Masson Lerco, Célia Sperandéo Macedo, Reinaldo José Silva, Daniela de Oliveira Pinheiro, César Tadeu Spadella   +4 more
doaj   +1 more source

The structural and functional organization of the podocyte filtration slits is regulated by Tjp1/ZO-1. [PDF]

PLoS ONE, 2014
Blood filtration in the kidney glomerulus is essential for physiological homeostasis. The filtration apparatus of the kidney glomerulus is composed of three distinct components: the fenestrated endothelial cells, the glomerular basement membrane, and ...
Masahiko Itoh, Kazuhiko Nakadate, Yasuhiro Horibata, Taiji Matsusaka, Jianliang Xu, Walter Hunziker, Hiroyuki Sugimoto   +6 more
doaj   +1 more source

Absence of Pressure-Driven Supersolid Flow at Low Frequency

, 2009
An important unresolved question in supersolid research is the degree to which the non-classical rotational inertia (NCRI) phenomenon observed in the torsional oscillator experiments of Kim and Chan, is evidence for a Bose-condensed supersolid state with
A. Andreev, Ann Sophie C. Rittner, Erich J. Mueller, G. Bonfait, John D. Reppy, Wonsuk Choi   +5 more
core   +1 more source

Abundances in planetary nebulae: NGC1535, NGC6629, He2-108, and Tc1 [PDF]

, 2011
The aim of the paper is to determine abundances in a group of PNe with uniform morphology. The PNe discussed are circular excited by rather low-temperature central stars. The relation between abundance and evolution is discussed. The mid-infrared spectra
Adams, Aller, Aller, Aller, Banerjee, Barker, Benjamin, Bernard Salas, Blocker, Cahn, Cami, Ciardullo, Condon, Corradi, Davey, de Freitas Pacheco, Feibelman, Fluks, Gathier, Gathier, Gregory, Grevesse, Griffith, Guerrero, Guiles, Henry, Herald, Higdon, Houck, Hummer, J. Bernard-Salas, Kerber, Kingsburgh, Kingsburgh, Krabbe, McKenna, Mendez, Mendez, Milingo, Milingo, Milingo, Milne, Milne, Napiwotzki, Pauldrach, Peimbert, Peimbert, Peimbert, Phillips, Porter, Pottasch, Pottasch, Pottasch, Pottasch, Pottasch, Pottasch, Pottasch, Pottasch, Pottasch, Preite-Martinez, R. Surendiranath, Rauch, S. R. Pottasch, Schwarz, Stanghellini, Stoy, Surendiranath, Torres-Peimbert, Tylenda, Weidemann, Williams, Wright   +71 more
core   +4 more sources