Results 31 to 40 of about 120,164 (279)
Nature Communications, 2020 Aspartimide formation is a frequently occurring problem during peptide synthesis. Here, the authors present cyanosulfurylides as a protection group that masks aspartic acid residues during solid phase peptide synthesis, thus preventing aspartimide ...
Kevin Neumann +3 more
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DNA display III. Solid-phase organic synthesis on unprotected DNA. [PDF]
PLoS Biology, 2004 DNA-directed synthesis represents a powerful new tool for molecular discovery. Its ultimate utility, however, hinges upon the diversity of chemical reactions that can be executed in the presence of unprotected DNA.
David R Halpin +3 more
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Heterocycles as a Peptidomimetic Scaffold: Solid-Phase Synthesis Strategies
Pharmaceuticals, 2021 Peptidomimetics are a privileged class of pharmacophores that exhibit improved physicochemical and biological properties. Solid-phase synthesis is a powerful tool for gaining rapid access to libraries of molecules from small molecules to biopolymers and ...
Aizhan Abdildinova +2 more
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Lanthanide-Mediated Dephosphorylation Used for Peptide Cleavage during Solid Phase Peptide Synthesis
Molecules, 2013 Lanthanide(III) ions can accelerate the hydrolysis of phosphomonoesters and phosphodiesters in neutral aqueous solution. In this paper, lanthanide-mediated dephosphorylation has been applied in aqueous media as an orthogonal cleavage condition that can ...
Byunghee Yoo, Mark D. Pagel
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Aza-peptides: expectations and reality [PDF]
Proceedings of the Estonian Academy of Sciences, 2022 The replacement of the α-carbon atom in an α-amino acid structure by a nitrogen atom yields alkylcarbazic acids, also known as α-aza amino acids.
Anu Ploom +4 more
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Recent Reports of Solid-Phase Cyclohexapeptide Synthesis and Applications
Molecules, 2018 Macrocyclic peptides are privileged scaffolds for drug development and constitute a significant portion of macrocyclic drugs on the market today in fields spanning from infectious disease to oncology.
Allan M. Prior +3 more
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Evaluation of greener solvents for solid-phase peptide synthesis
Green Chemistry Letters and Reviews, 2021 Polar aprotic solvents such as N,N-Dimethylformamide (DMF), N-methyl-2-pyrrolidone (NMP), N,N’-dimethylacetamide (DMAc) and chlorinated solvent such dichloromethane (DCM) are the most widely used solvents for Fmoc solid-phase peptide synthesis (SPPS ...
Katarzyna Wegner +4 more
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Peptide synthesis: ball-milling, in solution, or on solid support, what is the best strategy?
Beilstein Journal of Organic Chemistry, 2017 While presenting particularly interesting advantages, peptide synthesis by ball-milling was never compared to the two traditional strategies, namely peptide syntheses in solution and on solid support (solid-phase peptide synthesis, SPPS).
Ophélie Maurin +5 more
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Peptides, solid-phase synthesis and characterization: Tailor-made methodologies
Electronic Journal of Biotechnology, 2023 Background: Solid-Phase Peptide Synthesis (SPPS) is a mature technique widely used in research and in production. There are different approaches that fulfill the diverse requirements, regarding the number, quantity and quality of peptides.
Fanny Guzmán +6 more
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Solid Phase Formylation of N-Terminus Peptides
Molecules, 2016 Formylation of amino groups is a critical reaction involved in several biological processes including post-translational modification of histones. The addition of a formyl group (CHO) to the N-terminal end of a peptide chain generates biologically active
Anna Lucia Tornesello +2 more
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