Results 91 to 100 of about 241 (129)
Juglorin, a new spermidine synthase inhibitor.
The Journal of Antibiotics, 1987 K, Hamaguchi +5 more
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Helicobacter pylori does not use spermidine synthase to produce spermidine
Biochemical and Biophysical Research Communications, 2017Helicobacter pylori is the primary pathogen associated to gastritis and gastric cancer. Growth of H. pylori depends on the availability of spermidine in vivo. Interestingly, the genome of H. pylori contains an incomplete set of genes for the classical pathway of spermidine biosynthesis.
Shannon Wing Ngor Au, Huawei Zhang
exaly +3 more sources
Nucleotide Sequence of Mouse Spermidine Synthase cDNA
DNA Sequence, 1994The nucleotide sequence of mouse cDNA for spermidine synthase appeared to contain 75 nucleotides of 5' untranslated region, an open reading frame of 909 nucleotides and 297 nucleotides of 3' untranslated region. The open reading frame encoded a polypeptide of 302 amino acids, displaying 95% similarity to human and 33% similarity to E.
Leena Alhonen +2 more
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Characterization of spermidine synthase from Trypanosoma brucei brucei
Molecular and Biochemical Parasitology, 1984Spermidine synthase from Trypanosoma brucei brucei was characterized and found to be similar to spermidine synthase from other sources. The Km for putrescine was found to be 0.2 mM and the Km for decarboxylated S-adenosylmethionine 0.1 microM. The approximate molecular weight of the enzyme was 74 000 as determined by a combination of molecular sieve ...
A J Bitonti, Peter P McCann, P P McCann
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Androgen regulation of spermidine synthase expression in the rat prostate
Prostate, 2002AbstractBACKGROUNDSpermidine synthase, an essential enzyme in the polyamine synthesis pathway, was identified as one of the androgen‐response genes in the rat ventral prostate. Characterization of androgen regulation of spermidine synthase is important to the understanding of androgenic regulation of polyamine synthesis.METHODSFull‐length cDNA encoding
Zhou Wang
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Genetic analysis of spermidine synthase from Leishmania donovani
Molecular and Biochemical Parasitology, 2001The polyamine biosynthetic pathway of protozoan parasites has been validated as a target in antiparasitic chemotherapy. To investigate this pathway at the biochemical and genetic level in a model parasite, the gene encoding spermidine synthase (SPDSYN), a key polyamine biosynthetic enzyme, has been cloned and sequenced from Leishmania donovani.
Sigrid Roberts +2 more
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Biochemical Pharmacology, 1993
Several inhibitors of aminopropyltransferases, developed recently in this laboratory, were tested for their specificity by measuring their effects on six enzyme activities related to polyamine biosynthesis and interconversion. Two of them, trans-4-methylcyclohexylamine (4MCHA) and N-(3-aminopropyl)cyclohexylamine (APCHA), selectively and potently ...
Keijiro Samejima +2 more
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Several inhibitors of aminopropyltransferases, developed recently in this laboratory, were tested for their specificity by measuring their effects on six enzyme activities related to polyamine biosynthesis and interconversion. Two of them, trans-4-methylcyclohexylamine (4MCHA) and N-(3-aminopropyl)cyclohexylamine (APCHA), selectively and potently ...
Keijiro Samejima +2 more
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Structure and Mechanism of Spermidine Synthases
Biochemistry, 2007Aminopropyltransferases transfer aminopropyl groups from decarboxylated S-adenosylmethionine to amine acceptors, forming polyamines. Structural and biochemical studies have been carried out with the human spermidine synthase, which is highly specific for putrescine as the amine acceptor, and the Thermotoga maritima spermidine synthase, which prefers ...
Hong, Wu +7 more
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Immunolocalisation of spermidine synthase in Solanum tuberosum
Phytochemistry, 2013Spermidine synthase (SPDS) catalyses the formation of spermidine, which is an essential polyamine and widespread in living organisms. Spermidine is formed from putrescine by transfer of an aminopropyl group from decarboxylated S-adenosylmethionine. Spermidine is also a precursor to further polyamines, such as spermine and thermospermine, most of which ...
Yvonne, Sichhart, Birgit, Dräger
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Putrescine derivatives as substrates of spermidine synthase
International Journal of Biochemistry, 19871. Derivatives of 1,4-butanediamine (putrescine) were studied in vitro and in vivo as potential substrates of spermidine synthase. 2. Substituents in the 1-position decreased the reaction rate by steric hindrance, and in the case of electron withdrawing groups there was an additional decrease due to the lowered basicity of the vicinal amino group.
S, Sarhan, F, Dezeure, N, Seiler
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