Results 81 to 90 of about 241 (129)

Spermidine restricts neonatal inflammation via metabolic shaping of polymorphonuclear myeloid-derived suppressor cells

The Journal of Clinical Investigation
Newborns exhibit a heightened vulnerability to inflammatory disorders due to their underdeveloped immune system, yet the underlying mechanisms remain poorly understood.
Jiale Chen, Lin Zhu, Zhaohai Cui, Yuxin Zhang, Ran Jia, Dongmei Zhou, Bo Hu, Wei Zhong, Jin Xu, Lijuan Zhang, Pan Zhou, Wenyi Mi, Haitao Wang, Zhi Yao, Ying Yu, Qiang Liu, Jie Zhou   +16 more
doaj   +1 more source

GhSPDS11 up-regulated spermidine synthase responding to alkaline tolerance in cotton

Plant Stress
Alkaline stress causes significant adverse effects that slows down the growth of plants and lowers the yield of crops; hence, it is a major challenge in cotton farming.
Hao Lan, Maohua Dai, Xiugui Chen, Juyun Zheng, Ruize Song, Xuke Lu, Fange Wu, Xin Yu, Xinrui Zhang, Zhining Yang, Menghao Zhang, Lixue Guo, Shuai Wang, Lanjie Zhao, Yupeng Cui, Xue-Rong Zhou, Xueyuan Li, Wuwei Ye   +17 more
doaj   +1 more source

Abnormal Polyamine Metabolism in Pancreatic Epithelial Cells aggravates chronic pancreatitis-associated preneoplastic lesions

Frontiers in Bioscience-Landmark
Background:Chronic pancreatitis (CP) is an independent risk factor for pancreatic cancer (PC). Investigation of the pathological progression of CP may help to elucidate the mechanisms underlying the progression of preneoplastic lesions in CP.Methods ...
Yuhong Zhang, Hongbin Wang, Xiaxia Shao, Yang Ling, Yongping Liu   +4 more
doaj   +1 more source

Fruit Architecture in Polyamine-Rich Tomato Germplasm Is Determined via a Medley of Cell Cycle, Cell Expansion, and Fruit Shape Genes

Plants, 2019
Shape and size are important features of fruits. Studies using tomatoes expressing yeast Spermidine Synthase under either a constitutive or a fruit-ripening promoter showed obovoid fruit phenotype compared to spherical fruit in controls, suggesting that ...
Raheel Anwar, Shazia Fatima, Autar K. Mattoo, Avtar K. Handa   +3 more
doaj   +1 more source

Loss-of-function variant in spermidine/spermine N1-acetyl transferase like 1 (SATL1) gene as an underlying cause of autism spectrum disorder

Scientific Reports
Autism spectrum disorder (ASD) is a complicated, lifelong neurodevelopmental disorder affecting verbal and non-verbal communication and social interactions. ASD signs and symptoms appear early in development before the age of 3 years.
Abdulfatah M. Alayoubi, Muhammad Iqbal, Hassan Aman, Jamil A. Hashmi, Laila Alayadhi, Khalid Al-Regaiey, Sulman Basit   +6 more
doaj   +1 more source

Enhancing the Spermidine Synthase-Based Polyamine Biosynthetic Pathway to Boost Rapid Growth in Marine Diatom Phaeodactylum tricornutum

Biomolecules
Diatoms, efficient carbon capture organisms, contribute to 20% of global carbon fixation and 40% of ocean primary productivity, garnering significant attention to their growth.
Hung-Yun Lin, Chung-Hsiao Liu, Yong-Ting Kang, Sin-Wei Lin, Hsin-Yun Liu, Chun-Ting Lee, Yu-Chen Liu, Man-Chun Hsu, Ya-Yun Chien, Shao-Ming Hong, Yun-Hsuan Cheng, Bing-You Hsieh, Han-Jia Lin   +12 more
doaj   +1 more source

The Aspergillus flavus Spermidine Synthase (spds) Gene, Is Required for Normal Development, Aflatoxin Production, and Pathogenesis During Infection of Maize Kernels

Frontiers in Plant Science, 2018
Aspergillus flavus is a soil-borne saprophyte and an opportunistic pathogen of both humans and plants. This fungus not only causes disease in important food and feed crops such as maize, peanut, cottonseed, and tree nuts but also produces the toxic and ...
Rajtilak Majumdar, Matt Lebar, Brian Mack, Rakesh Minocha, Subhash Minocha, Carol Carter-Wientjes, Christine Sickler, Kanniah Rajasekaran, Jeffrey W. Cary   +8 more
doaj   +1 more source

trans-4-Methylcyclohexylamine, a potent new inhibitor of spermidine synthase.

Chemical and Pharmaceutical Bulletin, 1988
Trans-4-methylcyclohexylamine was found to inhibit pig spermidine synthase potently in assay conditions containing 50 μM of decarboxylated S-adenosylmethionine. It showed 50% inhibition at 1.7 μM compared to 8.1 μM for cyclohexylamine, and 2.5 μM for S-adenosyl-1, 8-diamino-3-thiooctane, known as the most potent inhibitor.
Shirahata, Akira, Morohoshi, Toru, Samejima, Keijiro   +2 more
openaire   +3 more sources

Reduction of spermine synthase enhances autophagy to suppress Tau accumulation

Cell Death and Disease
Precise polyamine metabolism regulation is vital for cells and organisms. Mutations in spermine synthase (SMS) cause Snyder–Robinson intellectual disability syndrome (SRS), characterized by significant spermidine accumulation and autophagy blockage in ...
Xianzun Tao, Jiaqi Liu, Zoraida Diaz-Perez, Jackson R. Foley, Ashley Nwafor, Tracy Murray Stewart, Robert A. Casero, R. Grace Zhai   +7 more
doaj   +1 more source

7-Prenyloxycoumarins as Promising Antileishmanial Agents: In Vitro, In Vivo, and In Silico Evaluation Against Leishmania amazonensis

Pharmaceuticals
Background/Objectives: Leishmaniasis remains a major neglected tropical disease, and current chemotherapeutic options are limited by toxicity and resistance in Leishmania species, including L. amazonensis.
Dirlei Nico, Daniel Clemente de Moraes, Anna Claudia Silva, Igor Nunes Taveira, Yasmin da Silva Fontes, Rosangela Sabbatini Capella Lopes, Cláudio Cerqueira Lopes, Antonio Ferreira-Pereira   +7 more
doaj   +1 more source