An Efficient Synthesis of Oxygen-Bridged Spirooxindoles via Microwave-Promoted Multicomponent Reaction [PDF]
Molecules, 2023 A microwave-promoted multicomponent reaction of isatins, α-amino acids and 1,4-dihydro-1,4-epoxynaphthalene is achieved under environmentally friendly conditions, delivering oxygen-bridged spirooxindoles within 15 min in good to excellent yields.
Yaojing Shi, Hua Zhao, Yufen Zhao
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Diastereoselective Three-Component 1,3-Dipolar Cycloaddition to Access Functionalized β-Tetrahydrocarboline- and Tetrahydroisoquinoline-Fused Spirooxindoles [PDF]
MoleculesA chemselective catalyst-free three-component 1,3-dipolar cycloaddition has been described. The unique polycyclic THPI and THIQs were creatively employed as dipolarophiles, which led to the formation of functionalized β-tetrahydrocarboline- and ...
Yongchao Wang +8 more
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The Therapeutic Potential of Spirooxindoles in Cancer: A Focus on p53–MDM2 Modulation [PDF]
PharmaceuticalsThe p53, often referred to as the “guardian of the genome”, is a well-established tumor-suppressor protein that plays a critical role in regulating the cell cycle, DNA repair, differentiation, and apoptosis, with its activity primarily modulated by the ...
Adel S. Girgis +8 more
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Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold [PDF]
Molecules, 2023 Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural spirooxindole-containing compounds have been identified as bio-promising agents. Synthetic analogs have also been synthesized utilizing different pathways.
Siva S. Panda +3 more
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Synthesis and Characterization of New Spirooxindoles Including Triazole and Benzimidazole Pharmacophores via [3+2] Cycloaddition Reaction: An MEDT Study of the Mechanism and Selectivity [PDF]
Molecules, 2023 A new series of spirooxindoles based on benzimidazole, triazole, and isatin moieties were synthesized via a [3+2] cycloaddition reaction protocol in one step. The single X-ray crystal structure of the intermediate triazole-benzimidazole 4 was solved. The
Saeed Alshahrani +7 more
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Natural-Product-Inspired Microwave-Assisted Synthesis of Novel Spirooxindoles as Antileishmanial Agents: Synthesis, Stereochemical Assignment, Bioevaluation, SAR, and Molecular Docking Studies. [PDF]
Molecules, 2023 Leishmaniasis is a neglected tropical disease, and there is an emerging need for the development of effective drugs to treat it. To identify novel compounds with antileishmanial properties, a novel series of functionalized spiro[indoline-3,2′-pyrrolidin]-
Sahu NK +12 more
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In Vitro and In Silico Evaluation of Isatin-Derived Spirooxindoles as Antituberculosis Drug Candidates. [PDF]
Chem Biol Drug DesTwo compounds, A16 and A17, were active against multidrug‐resistant Mycobacterium tuberculosis isolates (PT‐12 and PT‐20), overcoming key resistance mutations in katG and rpoB, while cytotoxicity assays confirmed that they are non‐toxic. A17 exhibited the highest antituberculosis activity, with molecular docking suggesting enoyl‐[acyl‐carrier‐protein ...
de Lima FR +11 more
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Morphological Profiling Identifies the Motor Protein Eg5 as Cellular Target of Spirooxindoles [PDF]
Angewandte Chemie, 2023 Oxindoles and iso-oxindoles are natural product-derived scaffolds that provide inspiration for the design and synthesis of novel biologically relevant compound classes.
Jie Liu +13 more
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Synthesis of COF-SO3H immobilized on manganese ferrite nanoparticles as an efficient nanocomposite in the preparation of spirooxindoles. [PDF]
Sci Rep, 2023 The synthesis of sulfonamide-functionalized magnetic porous nanocomposites is highly significant in chemistry due to their exceptional properties and potential as catalysts.
Moein Najafabadi S, Safaei Ghomi J.
europepmc +2 more sources
Green Synthesis of Spirooxindoles via Lipase-Catalyzed One-Pot Tandem Reaction in Aqueous Media [PDF]
Catalysts, 2023 The development of non-natural enzymatic catalysis is important for multicomponent tandem organic transformations. However, the delicate acting environments of biological enzymes still present some challenges in the synthesis of spirooxindole skeleton ...
Yong Tang +7 more
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