Results 1 to 10 of about 527 (134)

Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold. [PDF]

Molecules, 2023
Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural spirooxindole-containing compounds have been identified as bio-promising agents. Synthetic analogs have also been synthesized utilizing different pathways. The present article summarizes the recent development of both natural and synthetic spirooxindole-containing ...
Panda SS, Girgis AS, Aziz MN, Bekheit MS.   +3 more
europepmc   +5 more sources

The Therapeutic Potential of Spirooxindoles in Cancer: A Focus on p53-MDM2 Modulation. [PDF]

Pharmaceuticals (Basel)
The p53, often referred to as the “guardian of the genome”, is a well-established tumor-suppressor protein that plays a critical role in regulating the cell cycle, DNA repair, differentiation, and apoptosis, with its activity primarily modulated by the ...
Girgis AS, Zhao Y, Nkosi A, Ismail NSM, Bekheit MS, Aboshouk DR, Aziz MN, Youssef MA, Panda SS.   +8 more
europepmc   +2 more sources

Preparation of spirocyclic oxindoles by cyclisation of an oxime to a nitrone and dipolar cycloaddition. [PDF]

Beilstein J Org Chem
Oxindoles are an important class of compounds with significant biological activities. Spirocyclic derivatives are present in a variety of natural products.
Ritchie BL, Longcake A, Coldham I.
europepmc   +2 more sources

Organocatalytic Access to Enantioenriched Spirooxindole-Based 4-Methyleneazetidines [PDF]

Molecules, 2017
This work describes the synthesis of enantioenriched spiro compounds, incorporating the azetidine and the oxindole motifs. The preparation relies on a formal [2 + 2] annulation reaction of isatin-derived N-tert-butylsulfonyl ketimines with allenoates. The asymmetric induction is secured by an organocatalytic strategy, exploiting a bifunctional cinchona-
Rainoldi, Giulia, Faltracco, Matteo, Spatti, Claudia, Silvani, Alessandra, Lesma, Giordano   +4 more
openaire   +4 more sources

Base-Catalyzed Reaction of Isatins and (3-Hydroxyprop-1-yn-1-yl)phosphonates as a Tool for the Synthesis of Spiro-1,3-dioxolane Oxindoles with Anticancer and Anti-Platelet Properties. [PDF]

Molecules
An approach to the synthesis of phosphoryl substituted spiro-1,3-dioxolane oxindoles was developed from the base-catalyzed reaction of various isatins with (3-hydroxyprop-1-yn-1-yl)phosphonates.
Murashkina AV, Bogdanov AV, Voloshina AD, Lyubina AP, Samorodov AV, Mitrofanov AY, Beletskaya IP, Smolyarchuk EA, Zavadich KA, Valiullina ZA, Nazmieva KA, Korunas VI, Krylova ID.   +12 more
europepmc   +2 more sources

Quantitative structure-activity relationship and ADME prediction studies on series of spirooxindoles derivatives for anti-cancer activity against colon cancer cell line HCT-116. [PDF]

Heliyon
Forty-one derivatives of spirooxindoles, active against HCT-116 colon cancer cells, underwent pharmacophore-based 3D-QSAR analysis to understand their correlation with anti-cancer activity. The study identified a seven-point pharmacophore model (ADHHRRR1)
Kaur S, Kaur J, Zarger BA, Islam N, Mir N.   +4 more
europepmc   +2 more sources

Discovery of a cytochrome P450 enzyme catalyzing the formation of spirooxindole alkaloid scaffold. [PDF]

Front Plant Sci, 2023
Spirooxindole alkaloids feature a unique scaffold of an oxindole ring sharing an atom with a heterocyclic moiety. These compounds display an extensive range of biological activities such as anticancer, antibiotics, and anti-hypertension.
Nguyen TM, Grzech D, Chung K, Xia Z, Nguyen TD, Dang TT.   +5 more
europepmc   +2 more sources

Optimized spirooxindole-pyrazole hybrids targeting the p53-MDM2 interplay induce apoptosis and synergize with doxorubicin in A549 cells. [PDF]

Sci Rep, 2023
Recently, cancer research protocols have introduced clinical-stage spirooxindole-based MDM2 inhibitors. However, several studies reported tumor resistance to the treatment.
Islam MS, Al-Majid AM, Sholkamy EN, Barakat A, Viale M, Menichini P, Speciale A, Loiacono F, Azam M, Verma VP, Yousuf S, Teleb M.   +11 more
europepmc   +2 more sources

Diastereoselective Three-Component 1,3-Dipolar Cycloaddition to Access Functionalized β-Tetrahydrocarboline- and Tetrahydroisoquinoline-Fused Spirooxindoles. [PDF]

Molecules
A chemselective catalyst-free three-component 1,3-dipolar cycloaddition has been described. The unique polycyclic THPI and THIQs were creatively employed as dipolarophiles, which led to the formation of functionalized β-tetrahydrocarboline- and ...
Wang Y, Chen Y, Duan S, Cao Y, Sun W, Zhang M, Zhao D, Hu D, Dong J.   +8 more
europepmc   +2 more sources

Selective construction of dispiro[indoline-3,2'-quinoline-3',3''-indoline] and dispiro[indoline-3,2'-pyrrole-3',3''-indoline] via three-component reaction. [PDF]

Beilstein J Org Chem, 2023
A convenient synthetic procedure for the construction of novel dispirooxindole motifs was successfully developed by base-promoted three-component reaction of ammonium acetate, isatins and in situ-generated 3-isatyl-1,4-dicarbonyl compounds.
Xiao Z, Xu F, Sun J, Yan CG.
europepmc   +2 more sources