Results 1 to 10 of about 1,434 (116)

The Synthesis of 3-Spirooxindole Derivatives. IV. The Conversion of 3-Spirooxindole to Indole Derivative.

Chemical and Pharmaceutical Bulletin, 1963
The conversion of 1-methylspiro (indoline-3, 1'-indolizine)-2-one to 12-methyl-1, 2, 3, 4, 6, 7, 12, 12b-octahydroindolo [2, 3-a] quinolizine is described as a preliminary for the chemical correlation of N-methylrhynchophyllane with N-methyldihydrocorynantheane.
Takeshi Oishi, Shizuo Maeno, Yoshio Ban
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Diastereoselective Synthesis and Structure of Spirooxindole Derivatives

HETEROCYCLES, 2003
Spiroindolinonisoxazolines (4 and 5h) are prepared from (E)- 1 or (Z)-3-arylidene-2-oxindoles (2) by nitrile oxide cycloaddition reactions. Only one regioisomer is detected in all cases, and the observed complete diastereoselection is established by unambigous structural assignments.
Francesco Risitano, Giovanni Grassi, Francesco Foti, Giuseppe Brunò, Archimede Rotondo   +4 more
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Nanoformulation of Spirooxindole and Methods for Treating Hepatocellular Carcinoma

Pharmaceutics
Objectives: This in vivo study introduces a newly developed spirooxindole derivative that is deemed safe and effective as a potential targeted therapy for various cancers. Methods: Extensive in vivo investigations, including histopathology, immunohistochemistry, and molecular biology, validated its potential for further preclinical and clinical ...
Assem Barakat, Fardous F. El‐Senduny, Mohammad Shahidul Islam, Abdullah Mohammed Al‐Majid, Yaseen A. M. M. Elshaier, Eman A. Mazyed, Farid A. Badria   +6 more
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Transition metal-catalyzed synthesis of spirooxindoles

RSC Advances, 2021
Spirooxindoles are used as anticancer-, antiviral-, antimicrobial agents etc. The use of transition metals as catalysts for the synthesis of spirooxindoles is advancing rapidly. Here, we focus on recent advances in transition metal-catalyzed synthesis of spirooxindoles.
P. V. Saranya, Mohan Neetha, Thaipparambil Aneeja, Gopinathan Anilkumar   +3 more
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Therapeutic Potential of Spirooxindoles as Antiviral Agents [PDF]

ACS Infectious Diseases, 2016
Antiviral therapeutics with profiles of high potency, low resistance, panserotype, and low toxicity remain challenging, and obtaining such agents continues to be an active area of therapeutic development. Due to their unique three-dimensional structural features, spirooxindoles have been identified as privileged chemotypes for antiviral drug ...
Pei Yong Shi, Jia Zhou, Eric A. Wold, Haiying Chen, Na Ye   +4 more
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Light‐Induced Domino and Multicomponent Reactions: How to Reach Molecular Complexity without a Catalyst

European Journal of Organic Chemistry, Volume 26, Issue 41, November 2, 2023., 2023
Is it possible to build up molecular complexity without the help of a catalyst? Yes, it is! With the suitable starting‐materials, a domino or multicomponent reaction can be initiated just turning on the right light. Abstract Achieving high molecular complexity can be not trivial, but the exploitation of domino reactions provides an atom‐ and step ...
Polyssena Renzi, Jacopo Scarfiello, Alberto Lanfranco, Annamaria Deagostino   +3 more
wiley   +1 more source

Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold

Molecules, 2023
Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural spirooxindole-containing compounds have been identified as bio-promising agents. Synthetic analogs have also been synthesized utilizing different pathways. The present article summarizes the recent development of both natural and synthetic spirooxindole-containing ...
Siva S. Panda, Adel S. Girgis, Marian N. Aziz, Mohamed S. Bekheit   +3 more
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Goldkatalysierte formale [4+2]‐Cycloaddition als Zugang zu antitumoraktiven spirozyklischen Oxindolen aus Alkinen und von Isatin abgeleiteten Ketiminen

Angewandte Chemie, Volume 135, Issue 34, August 21, 2023., 2023
Durch eine goldkatalysierte Cycloadditionsreaktion von Alkinen mit von Isatin abgeleiteten Ketiminen wurde ein neuartiges Protokoll zur Synthese von Spirooxindolen entwickelt, die eine hervorragende antiproliferative Aktivität auf menschliche Tumorzelllinien besitzen.
Yaowen Liu, Martin C. Dietl, Robin Heckershoff, Chunyu Han, Hongwei Shi, Matthias Rudolph, Frank Rominger, Isabella Caligiuri, Kanwal Asif, Muhammad Adeel, Thomas Scattolin, A. Stephen K. Hashmi   +11 more
wiley   +1 more source

Gold‐Catalyzed Formal [4+2] Cycloaddition as Access to Antitumor‐Active Spirocyclic Oxindoles from Alkynes and Isatin‐Derived Ketimines

Angewandte Chemie International Edition, Volume 62, Issue 34, August 21, 2023., 2023
A novel protocol for the synthesis of spirooxindoles that possess excellent antiproliferative activity on human tumor cell lines was achieved through a gold‐catalyzed cycloaddition reaction of alkynes with isatin‐derived ketimines. Various functionalized and readily available alkynes reacted under mild reaction conditions. Abstract Due to its excellent
Yaowen Liu, Martin C. Dietl, Robin Heckershoff, Chunyu Han, Hongwei Shi, Matthias Rudolph, Frank Rominger, Isabella Caligiuri, Kanwal Asif, Muhammad Adeel, Thomas Scattolin, A. Stephen K. Hashmi   +11 more
wiley   +1 more source

Stereoselective Synthesis of Multifunctional Spirooxindole-Dihydrofuran Derivatives

Polycyclic Aromatic Compounds, 2021
A facile and efficient protocol for the diastereoselective synthesis of novel spirooxindole-dihydrofurans has been developed by the three-component condensation of isatin derivatives, 3-cyanoacetyl indole, and N-phenacylpyridinium bromide in the presence of triethylamine base. The reaction was carried out in ethanol under reflux conditions, and various
Hashem Bagheri, Robabeh Baharfar, Razieh Azimi   +2 more
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