Results 91 to 100 of about 3,124 (225)
Beilstein Journal of Organic Chemistry, 2011 A thermal [2 + 2] cycloaddition reaction of allene-ynes has been used to transform chiral non-racemic allenyl oxindoles into chiral non-racemic spirooxindoles containing an alkylidene cyclobutene moiety.
Kay M. Brummond, Joshua M. Osbourn
doaj +1 more source
Advanced Synthesis &Catalysis, Volume 366, Issue 19, Page 3926-3942, October 8, 2024.Abstract Chiral N‐heterocyclic compounds are key structures in natural compounds and pharmaceuticals, and they serve as essential building blocks of functional materials. Catalytic asymmetric cycloaddition reactions represent one of the most efficient synthetic strategies for constructing optically active heterocycles.
Jong‐Un Park, Ju Hyun Kim
wiley +1 more source
ChemistrySelect, Volume 9, Issue 37, October 4, 2024.We report a visible‐light‐mediated, catalyst‐free multicomponent reaction for the efficient synthesis of spirooxindole‐linked fused pyrans. The reaction involves isatin, malononitrile or its derivatives, and various cyclic 1,3‐dicarbonyl compounds such as 4‐hydroxy‐1‐methyl‐2(1H)‐quinolone, 4‐hydroxycoumarin, 4‐hydroxythiocoumarin, or barbituric acid ...
Nurabul Mondal +3 more
wiley +1 more source
Dynamic stereoselective annulation via aldol-oxa-cyclization cascade reaction to afford spirooxindole pyran polycycles [PDF]
, 2019 Spiro polycyclic compounds bearing pyran ring systems are found in bioactive molecules, and we recently reported the construction of spirooxindole all-carbon polycycles.
Fujie Tanaka, Muhammad Sohail
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Stereoselective Synthesis of Spirooxindole Amides through Nitrile Hydrozirconation [PDF]
Organic Letters, 2010 Spirooxindole amides can be prepared by the intramolecular addition of functionalized indoles into acylimines that are accessed from nitriles by hydrozirconation and acylation. The stereochemical outcome at the quaternary center was controlled by the steric bulk of the substituent at the 2-position of the indole unit.
Qing Xiao +2 more
openaire +3 more sources
Isoniazid Hybrids As Potential Antitubercular Agents
ChemistrySelect, Volume 9, Issue 38, October 11, 2024.Molecular hybridization is a rational drug design strategy that combines two or more covalently binding pharmacological agents into a single multifunctional molecule. The present review discusses the recent functionalizing of isoniazid to new hybrids tackling the menace of various forms of drug‐resistant tuberculosis and generating potential leads for ...
Sahil Mishra +2 more
wiley +1 more source
PROteolysis‐Targeting Chimeras (PROTACs) in leukemia: overview and future perspectives
MedComm, Volume 5, Issue 6, June 2024.Antileukemic PROteolysis‐TArgeting Chimeras (PROTACs) induce degradation of leukemia‐associated targets, including resistance‐conferring mutant forms. PROTACs against leukemia have increased dramatically. Most antileukemic PROTACs, through an event‐driven mechanism, degrade the target potently, quickly, selectively, and with a long duration of action ...
André T. S. Vicente +1 more
wiley +1 more source
Journal of Chemistry, 2017 New polycyclic-fused isoxazolo[4,5-e]pyridines and spirooxindoles were obtained via multicomponent reaction of 5-amino-3-methylisoxazole, indan-1,3-dione, and aromatic aldehydes and reaction of 5-amino-3-methylisoxazole, isatin, and β-diketones in the ...
Emel Pelit
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Novel concepts and methodologies in pseudo natural product chemistry [PDF]
, 2021 Natural products (NPs) are an inspiring source for chemical biology and drug discovery research, featuring complex and diverse structures. However, the chemical space explored by nature is limited by the biosynthetic precursors and machineries available ...
Liu, Jie
core
From Conventional to Sustainable Catalytic Approaches for Heterocycles Synthesis
ChemSusChem, Volume 17, Issue 8, April 22, 2024.Catalysed synthetic methods, such as transition metals, organocatalysts, photocatalysts, iodine‐catalysed reaction, electrochemical reactions and green innovative methods are of great interest for the sustainable synthesis of heterocyclic compounds, important building blocks for several applications.
Carla Rizzo +4 more
wiley +1 more source