Results 101 to 110 of about 3,294 (234)
Multicomponent Reaction Discovery: Three-Component Synthesis of Spirooxindoles [PDF]
Organic Letters, 2010 The Lewis acid-catalyzed, three-component reaction of isatin and two 1,3-dicarbonyl compounds is reported. Reactions proceed with high efficiency under mild reaction conditions and with good functional group tolerance to afford spirooxindole pyranochromenedione derivatives.
Bo, Liang +3 more
openaire +2 more sources
Advanced Synthesis &Catalysis, Volume 366, Issue 24, Page 5008-5014, December 17, 2024.Abstract In this work, we present an organocatalytic spiroannulation method that provides access to spirocyclic benzofuran‐2‐ones. The reaction proceeds via the generation of an azolium dienolate from an α‐bromo‐α,β‐unsaturated aldehyde using a chiral N‐heterocyclic carbene, followed by annulation with benzofuran‐2‐one‐derived alkenes.
Ladislav Lóška +8 more
wiley +1 more source
Dynamic stereoselective annulation via aldol-oxa-cyclization cascade reaction to afford spirooxindole pyran polycycles [PDF]
, 2019 Spiro polycyclic compounds bearing pyran ring systems are found in bioactive molecules, and we recently reported the construction of spirooxindole all-carbon polycycles.
Fujie Tanaka, Muhammad Sohail
core +2 more sources
Facile one-pot, multi-component reaction to synthesize spirooxindole-annulated thiopyran derivatives under environmentally benevolent conditions [PDF]
, 2022 Firouz Matloubi Moghaddam +1 more
openalex +1 more source
European Journal of Organic Chemistry, Volume 27, Issue 41, November 4, 2024.A diaminomethylenemalononitrile organocatalyst promoted asymmetric cascade Michael/Michael reactions between a 2‐(trifluoromethylmethylene)indane‐1,3‐dione derivative and α‐alkylidene succinimides, resulting in spiroindane‐1,3‐dione derivatives.
Ryo Tsuyusaki +4 more
wiley +1 more source
Synthetic Methodologies Using Nucleophile-Electrophile Chemistry [PDF]
, 2023 Synthetic organic chemistry is a vital part of the modern world – making up 15-20% of the U.S. economy. New synthetic reactions can lower manufacturing costs and create more environmentally friendly processes.
Hood, Jacob C.
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ChemistryOpen, Volume 13, Issue 11, November 2024.This review highlights recent advances in multicomponent reactions using 2‐aminobenzothiazole as a starting material in the synthesis of diverse heterocycles. These reactions enable the efficient and sustainable construction of novel bioactive molecules and pharmaceuticals.
Ramin Javahershenas +3 more
wiley +1 more source
Novel concepts and methodologies in pseudo natural product chemistry [PDF]
, 2021 Natural products (NPs) are an inspiring source for chemical biology and drug discovery research, featuring complex and diverse structures. However, the chemical space explored by nature is limited by the biosynthetic precursors and machineries available ...
Liu, Jie
core
Beilstein Journal of Organic Chemistry, 2010 The synthesis of C3-carbocyclic spirooxindoles was realized by way of an intramolecular [2 + 2] cycloaddition reaction between a vinylidene indolin-2-one and an alkyne.
Kay M. Brummond, Joshua M. Osbourn
doaj +1 more source
Synthesis and characterization of a new spirooxindole grafted pyrrolidino/piperidine moiety [PDF]
, 2021 yasmine abdel Aziz +7 more
openalex +1 more source