Results 101 to 110 of about 4,752 (252)
Dynamic stereoselective annulation via aldol-oxa-cyclization cascade reaction to afford spirooxindole pyran polycycles [PDF]
, 2019 Spiro polycyclic compounds bearing pyran ring systems are found in bioactive molecules, and we recently reported the construction of spirooxindole all-carbon polycycles.
Fujie Tanaka, Muhammad Sohail
core +2 more sources
Cooperative Vinylogous Enamine and Metal Catalysis
ChemCatChem, Volume 17, Issue 7, April 4, 2025.This review describes transformations combining vinylogous enamine catalysis with transition metal or Lewis acid catalysis that have emerged since the seminal report of dienamine catalysis in 2006. These transformations span numerous reaction classes, including alkylation, allylation, propargylation, oxyamination, dimerization, as well as cascade ...
Stacey E. Brenner‐Moyer
wiley +1 more source
Diversity-oriented synthesis as a tool for identifying new modulators of mitosis. [PDF]
, 2014 The synthesis of diverse three-dimensional libraries has become of paramount importance for obtaining better leads for drug discovery. Such libraries are predicted to fare better than traditional compound collections in phenotypic screens and against ...
Alza, Esther +8 more
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Microwave‐Assisted Multicomponent Synthesis of Spirooxindole Dihydropyridine Bisphosphonates
European Journal of Organic Chemistry, Volume 28, Issue 6, February 10, 2025.A new, simple, catalyst‐ and solvent‐free microwave‐assisted multicomponent method was developed for the synthesis of spirooxindole dihydropyridine bisphosphonates as a new family of compounds by the one‐pot reaction of isatins, β‐ketophosphonates and primary amines.
Bettina Rávai +3 more
wiley +1 more source
Synthetic Methodologies Using Nucleophile-Electrophile Chemistry [PDF]
, 2023 Synthetic organic chemistry is a vital part of the modern world – making up 15-20% of the U.S. economy. New synthetic reactions can lower manufacturing costs and create more environmentally friendly processes.
Hood, Jacob C.
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Advanced Synthesis &Catalysis, Volume 366, Issue 24, Page 5008-5014, December 17, 2024.Abstract In this work, we present an organocatalytic spiroannulation method that provides access to spirocyclic benzofuran‐2‐ones. The reaction proceeds via the generation of an azolium dienolate from an α‐bromo‐α,β‐unsaturated aldehyde using a chiral N‐heterocyclic carbene, followed by annulation with benzofuran‐2‐one‐derived alkenes.
Ladislav Lóška +8 more
wiley +1 more source
Novel concepts and methodologies in pseudo natural product chemistry [PDF]
, 2021 Natural products (NPs) are an inspiring source for chemical biology and drug discovery research, featuring complex and diverse structures. However, the chemical space explored by nature is limited by the biosynthetic precursors and machineries available ...
Liu, Jie
core
Journal of Chemistry, 2017 New polycyclic-fused isoxazolo[4,5-e]pyridines and spirooxindoles were obtained via multicomponent reaction of 5-amino-3-methylisoxazole, indan-1,3-dione, and aromatic aldehydes and reaction of 5-amino-3-methylisoxazole, isatin, and β-diketones in the ...
Emel Pelit
doaj +1 more source
Stereoselective Synthesis of Spirooxindole Amides through Nitrile Hydrozirconation [PDF]
Organic Letters, 2010 Spirooxindole amides can be prepared by the intramolecular addition of functionalized indoles into acylimines that are accessed from nitriles by hydrozirconation and acylation. The stereochemical outcome at the quaternary center was controlled by the steric bulk of the substituent at the 2-position of the indole unit.
Qing Xiao +2 more
openaire +3 more sources
European Journal of Organic Chemistry, Volume 27, Issue 41, November 4, 2024.A diaminomethylenemalononitrile organocatalyst promoted asymmetric cascade Michael/Michael reactions between a 2‐(trifluoromethylmethylene)indane‐1,3‐dione derivative and α‐alkylidene succinimides, resulting in spiroindane‐1,3‐dione derivatives.
Ryo Tsuyusaki +4 more
wiley +1 more source