Results 21 to 30 of about 3,124 (225)

Selective construction of dispiro[indoline-3,2'-quinoline-3',3''-indoline] and dispiro[indoline-3,2'-pyrrole-3',3''-indoline] via three-component reaction [PDF]

Beilstein Journal of Organic Chemistry, 2023
A convenient synthetic procedure for the construction of novel dispirooxindole motifs was successfully developed by base-promoted three-component reaction of ammonium acetate, isatins and in situ-generated 3-isatyl-1,4-dicarbonyl compounds.
Ziying Xiao, Fengshun Xu, Jing Sun, Chao-Guo Yan   +3 more
doaj   +2 more sources

Base-Catalyzed Reaction of Isatins and (3-Hydroxyprop-1-yn-1-yl)phosphonates as a Tool for the Synthesis of Spiro-1,3-dioxolane Oxindoles with Anticancer and Anti-Platelet Properties [PDF]

Molecules
An approach to the synthesis of phosphoryl substituted spiro-1,3-dioxolane oxindoles was developed from the base-catalyzed reaction of various isatins with (3-hydroxyprop-1-yn-1-yl)phosphonates.
Arina V. Murashkina, Andrei V. Bogdanov, Alexandra D. Voloshina, Anna P. Lyubina, Alexandr V. Samorodov, Alexander Y. Mitrofanov, Irina P. Beletskaya, Elena A. Smolyarchuk, Kseniya A. Zavadich, Zulfiya A. Valiullina, Kseniya A. Nazmieva, Vladislav I. Korunas, Irina D. Krylova   +12 more
doaj   +2 more sources

Discovery of a cytochrome P450 enzyme catalyzing the formation of spirooxindole alkaloid scaffold [PDF]

Frontiers in Plant Science, 2023
Spirooxindole alkaloids feature a unique scaffold of an oxindole ring sharing an atom with a heterocyclic moiety. These compounds display an extensive range of biological activities such as anticancer, antibiotics, and anti-hypertension.
Tuan-Anh M. Nguyen, Dagny Grzech, Khoa Chung, Zhicheng Xia, Trinh-Don Nguyen, Thu-Thuy T. Dang   +5 more
doaj   +2 more sources

Chemo-/Regio-Selective Synthesis of Novel Functionalized Spiro[pyrrolidine-2,3′-oxindoles] under Microwave Irradiation and Their Anticancer Activity [PDF]

Molecules, 2023
A novel series of nitrostyrene-based spirooxindoles were synthesized via the reaction of substituted isatins 1a–b, a number of α-amino acids 2a–e and (E)-2-aryl-1-nitroethenes 3a–e in a chemo/regio-selective manner using [3+2] cycloaddition (Huisgen ...
Richa Sharma, Lalit Yadav, Ali Adnan Nasim, Ravi Kant Yadav, Rui Hong Chen, Neha Kumari, Fan Ruiqi, Ashoke Sharon, Nawal Kishore Sahu, Sirish Kumar Ippagunta, Paolo Coghi, Vincent Kam Wai Wong, Sandeep Chaudhary   +12 more
doaj   +2 more sources

Diastereoselective Formal 1,3-Dipolar Cycloaddition of Trifluoroethyl Amine-Derived Ketimines Enables the Desymmetrization of Cyclopentenediones [PDF]

Molecules, 2023
In this research, a metal-free diastereoselective formal 1,3-dipolar cycloaddition of N-2,2,2-trifluoroethylisatin ketimines and cyclopentene-1,3-diones which can efficiently lead to the desymmetrization of cyclopentene-1,3-diones is developed.
Lin-Qiang Li, Jian-Qiang Zhao, Yan-Ping Zhang, Yong You, Zhen-Hua Wang, Zhen-Zhen Ge, Ming-Qiang Zhou, Wei-Cheng Yuan   +7 more
doaj   +2 more sources

Palladium-catalyzed difluorocarbene transfer enables access to enantioenriched chiral spirooxindoles [PDF]

Nature Communications
We disclose herein an unprecedented Pd-catalyzed difluorocarbene transfer reaction, which assembles a series of structurally interesting chiral spiro ketones with generally over 90% ee.
Zhiwen Nie, Keqin Wu, Xiaohang Zhan, Weiran Yang, Zhong Lian, Shaoquan Lin, Shou-Guo Wang, Qin Yin   +7 more
doaj   +2 more sources

Construction of Spirooxindole Skeleton Through Intramolecular Dieckmann Cyclization [PDF]

Natural Products and Bioprospecting, 2017
A highly efficient and direct approach was developed to construct the structurally diverse spirooxindole skeleton, which is an important basic motif in natural products. Both the 3,3'-pyrrolidonyl spirooxindoles and spiroindolin-2-one δ-lactones were smoothly obtained by the intramolecular Dieckmann cyclization of oxindoles in excellent yield under ...
Zhi-Qiang Pan, Chengfeng Xia, Ting Wu
openaire   +5 more sources

Novel spirooxindole-triazole derivatives: unveiling [3+2] cycloaddition reactivity through molecular electron density theory and investigating their potential cytotoxicity against HepG2 and MDA-MB-231 cell lines [PDF]

Frontiers in Chemistry
A novel analogue of hybrid spirooxindoles was synthesized employing a systematic multistep synthetic approach. The synthetic protocol was designed to obtain a series of spirooxindole derivatives incorporating triazolyl-s-triazine framework via [3 + 2 ...
Ihab Shawish, Samha Al Ayoubi, Ayman El-Faham, Ali Aldalbahi, Fardous F. El-Senduny, Fardous F. El-Senduny, Farid A. Badria, Mar Ríos-Gutiérrez, Hassan H. Hammud, Sajda Ashraf, Zaheer Ul-Haq, Assem Barakat   +11 more
doaj   +2 more sources

Silica/APTPOSS anchored on MnFe2O4 as an efficient nanomagnetic composite for the preparation of spiro-pyrano [2, 3-c] chromene derivatives [PDF]

BMC Chemistry
The synthesis of Octakis [3- (3-amino propyl triethoxysilane) propyl] octa-silsesquioxane (APTPOSS), a derivative of polyhedral oligomeric silsesquioxane, was utilized to produce an efficient nanocomposite.
Samira Moein-Najafabadi, Javad Safaei-Ghomi   +1 more
doaj   +2 more sources

Asymmetric Synthesis of Spirooxindoles via Nucleophilic Epoxidation Promoted by Bifunctional Organocatalysts [PDF]

Molecules, 2018
Taking into account the postulated reaction mechanism for the organocatalytic epoxidation of electron-poor olefins developed by our laboratory, we have investigated the key factors able to positively influence the H-bond network installed inside the ...
Abbate, Sergio, Gasperi, Tecla, Longhi, Giovanna, Lupattelli, Paolo, Mazzeo, Giuseppe, Mazziotta, Andrea, Miceli, Martina, Palumbo, Chiara, Roma, Elia, Tosi, Eleonora   +9 more
core   +4 more sources