Results 31 to 40 of about 3,294 (234)

Natural product-inspired [3 + 2] cycloaddition-based spirooxindoles as dual anticancer agents: synthesis, characterization, and biological evaluation by in vitro and in silico methods. [PDF]

RSC Med Chem
Nivetha N, Don Hamid J, Simha N A, Devegowda D, Ramu R, Velmathi S.   +5 more
europepmc   +3 more sources

Synthesis of Tetracyclic Spirooxindolepyrrolidine-Engrafted Hydantoin Scaffolds: Crystallographic Analysis, Molecular Docking Studies and Evaluation of Their Antimicrobial, Anti-Inflammatory and Analgesic Activities

Molecules, 2023
In a sustained search for novel potential drug candidates with multispectrum therapeutic application, a series of novel spirooxindoles was designed and synthesized via regioselective three-component reaction between isatin derivatives, 2-phenylglycine ...
Amani Toumi, Faiza I.A. Abdella, Sarra Boudriga, Tahani Y. A. Alanazi, Asma K. Alshamari, Ahlam Abdulrahman Alrashdi, Amal Dbeibia, Khaled Hamden, Ismail Daoud, Michael Knorr, Jan-Lukas Kirchhoff, Carsten Strohmann   +11 more
doaj   +1 more source

Recent Advances in Green Approaches for Synthesis of Oxindole Derivatives [PDF]

, 2023
Oxindole derivatives are nitrogen-containing, five-membered heterocyclic molecules found in both natural and synthetic substances with diverse biological functions.
D.M.T.A.Samaradiwakara, H.H.Kandambi, K.G.U.R. Kumarasinghe   +2 more
core   +2 more sources

Synthesis of new functionalized thiazolo pyridine-fused and thiazolo pyridopyrimidine-fused spirooxindoles via one-pot reactions

Heliyon, 2020
A sequential multi-component reaction of the nitroketene dithioacetals, cysteamine hydrochloride, isatin and different CH-acids is described. This efficient method provides new functionalized thiazolo pyridine-fused spirooxindoles and thiazolo ...
Shima Nasri, Mohammad Bayat, Hassan Vasheghani Farahani, Solmaz Karami   +3 more
doaj   +1 more source

Design, synthesis, and antitumor activity of novel dispiro[oxindole-cyclohexanone]-pyrrolidines [PDF]

, 2022
Background: Spirooxindoles are privileged scaffolds in medicinal chemistry, which were identified through Wang’s pioneering work as inhibitors of MDM2-p53 interactions.
Azab, Mohamed, Bawzeer, Majed, Elagawany, Mohamed, Elgendy, Bahaa, Gouda, Magy, Hegazy, Lamees, Rateb, Mostafa, Yaseen, Mohammed   +7 more
core   +2 more sources

The Solubility Studies and the Complexation Mechanism Investigations of Biologically Active Spiro[cyclopropane-1,3′-oxindoles] with β-Cyclodextrins

Pharmaceutics, 2023
In this work, we first improved the aqueous solubility of biologically active spiro[cyclopropane-1,3′-oxindoles] (SCOs) via their complexation with different β-cyclodextrins (β-CDs) and proposed a possible mechanism of the complex formation.
Anna A. Kravtsova, Anna A. Skuredina, Alexander S. Malyshev, Irina M. Le-Deygen, Elena V. Kudryashova, Ekaterina M. Budynina   +5 more
doaj   +1 more source

Electrochemical synthesis of spirooxindole-pyranopyrazole and spirooxindole-chromene derivatives as inhibitors of acetylcholinesterase. [PDF]

BMC Chem
Elsapagh RM, Osman EO, Hafez AM, El-Nassan HB.   +3 more
europepmc   +3 more sources

1,3-Dipolar cycloadditions of azomethine imines [PDF]

, 2015
Azomethine imines are considered 1,3-dipoles of the aza-allyl type which are transient intermediates and should be generated in situ but can also be stable and isolable compounds.
Nájera, Carmen, Sansano, Jose M., Yus, Miguel   +2 more
core   +3 more sources

Photochemical aryl radical cyclizations to give (E)-3-Ylideneoxindoles [PDF]

, 2014
(E)-3-Ylideneoxindoles are prepared in methanol in reasonable to good yields, as adducts of photochemical 5-exo-trig of aryl radicals, in contrast to previously reported analogous radical cyclizations initiated by tris(trimethylsilyl)silane and azo ...
Aldabbagh, Fawaz, Allart-Simon, Ingrid, Gerard, Stephane, Gurry, Michael, McArdle, Patrick, Sapi, Janos   +5 more
core   +2 more sources

Enantioselective Synthesis of Spiro[indolizidine-1,3 '-oxindoles] [PDF]

, 2020
A three-step procedure for the enantioselective synthesis of spiro[indolizidine-1,3'-oxindoles], consisting of a stereoselective cyclocondensation reaction between (S)-tryptophanol and a prochiral or racemic 5-oxoester, bromination of the resulting ...
Amat Tusón, Mercedes, Bosch Cartes, Joan, Gazzola, Silvia, Luque Garriga, F. Xavier, Massi, Lucia, Molins i Grau, Elies, Pérez Bosch, Maria, Ramos, Carlos, Taglienti, Chiara, Viayna Gaza, Antonio, Yayik, Nihan   +10 more
core   +1 more source