Results 31 to 40 of about 4,752 (252)

Palladium-catalyzed difluorocarbene transfer enables access to enantioenriched chiral spirooxindoles [PDF]

Nature Communications
We disclose herein an unprecedented Pd-catalyzed difluorocarbene transfer reaction, which assembles a series of structurally interesting chiral spiro ketones with generally over 90% ee.
Zhiwen Nie, Keqin Wu, Xiaohang Zhan, Weiran Yang, Zhong Lian, Shaoquan Lin, Shou-Guo Wang, Qin Yin   +7 more
doaj   +2 more sources

Synthesis of spirooxindoles via formal acetylene insertion into a common palladacycle intermediate. [PDF]

Chem Sci, 2023
Abel-Snape X, Johnson CE, Imbriaco B, Lautens M.   +3 more
europepmc   +3 more sources

Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
In the current medical era, spirooxindole motif stands out as a privileged heterospirocyclic scaffold that represents the core for a wide range of bioactive naturally isolated products (such as Strychnofoline and spirotryprostatins A and B) and synthetic
Sara T. Al-Rashood, Ahmed R. Hamed, Ghada S. Hassan, Hamad M. Alkahtani, Abdulrahman A. Almehizia, Amal Alharbi, Mohammad M. Al-Sanea, Wagdy M. Eldehna   +7 more
doaj   +2 more sources

Diastereoselective Synthesis and Structure of Spirooxindole Derivatives

HETEROCYCLES, 2003
Spiroindolinonisoxazolines (4 and 5h) are prepared from (E)- 1 or (Z)-3-arylidene-2-oxindoles (2) by nitrile oxide cycloaddition reactions. Only one regioisomer is detected in all cases, and the observed complete diastereoselection is established by unambigous structural assignments.
Francesco Risitano, Giovanni Grassi, Francesco Foti, Giuseppe Brunò, Archimede Rotondo   +4 more
openalex   +4 more sources

Novel spirooxindole-triazole derivatives: unveiling [3+2] cycloaddition reactivity through molecular electron density theory and investigating their potential cytotoxicity against HepG2 and MDA-MB-231 cell lines [PDF]

Frontiers in Chemistry
A novel analogue of hybrid spirooxindoles was synthesized employing a systematic multistep synthetic approach. The synthetic protocol was designed to obtain a series of spirooxindole derivatives incorporating triazolyl-s-triazine framework via [3 + 2 ...
Ihab Shawish, Samha Al Ayoubi, Ayman El-Faham, Ali Aldalbahi, Fardous F. El-Senduny, Fardous F. El-Senduny, Farid A. Badria, Mar Ríos-Gutiérrez, Hassan H. Hammud, Sajda Ashraf, Zaheer Ul-Haq, Assem Barakat   +11 more
doaj   +2 more sources

Silica/APTPOSS anchored on MnFe2O4 as an efficient nanomagnetic composite for the preparation of spiro-pyrano [2, 3-c] chromene derivatives [PDF]

BMC Chemistry
The synthesis of Octakis [3- (3-amino propyl triethoxysilane) propyl] octa-silsesquioxane (APTPOSS), a derivative of polyhedral oligomeric silsesquioxane, was utilized to produce an efficient nanocomposite.
Samira Moein-Najafabadi, Javad Safaei-Ghomi   +1 more
doaj   +2 more sources

DABCO-promoted highly diastereo- and regioselective construction of C-3 functionalized spirooxindoles via [3 + 2] cycloaddition of 2-aryl/heteroarylidene-1H-indene-1,3(2H)-diones with N-2,2,2-trifluoroethylisatin ketimines at ambient conditions. [PDF]

RSC Adv, 2022
Prasad MS, Bharani S, Sharief SM, Ravi M, Sivaprakash M, Borah B, Chowhan LR.   +6 more
europepmc   +3 more sources

Asymmetric Synthesis of Spirooxindoles via Nucleophilic Epoxidation Promoted by Bifunctional Organocatalysts [PDF]

Molecules, 2018
Taking into account the postulated reaction mechanism for the organocatalytic epoxidation of electron-poor olefins developed by our laboratory, we have investigated the key factors able to positively influence the H-bond network installed inside the ...
Martina Miceli, Andrea Mazziotta, Chiara Palumbo, Elia Roma, Eleonora Tosi, Giovanna Longhi, Sergio Abbate, Paolo Lupattelli, Giuseppe Mazzeo, Tecla Gasperi   +9 more
doaj   +4 more sources

Ultrafast and efficient continuous flow organic synthesis with a modified extruder-grinder system [PDF]

Scientific Reports
The study introduces a groundbreaking continuous system that combines an extruder and grinder to enable catalyst-free and solvent-free reactions under mild conditions.
Omid Hosseinchi Qareaghaj, Mohammad Ghaffarzadeh, Najmedin Azizi   +2 more
doaj   +2 more sources

Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bioactivity approach. [PDF]

RSC Adv
Nafie MS, Shawish I, Fahmy SA, Diab MK, Abdelfattah MM, Hassen BM, Darwish KM, El-Faham A, Barakat A.   +8 more
europepmc   +2 more sources