Results 41 to 50 of about 3,124 (225)

3′,4′-Dihydro-2′H-spiro[indoline-3,1′-isoquinolin]-2-ones as potential anti-cancer agents: synthesis and preliminary screening [PDF]

Royal Society Open Science, 2020
Both tetrahydroisoquinolines (THIQs) and oxindoles (OXs) display a broad range of biological activities including anti-cancer activity, and are therefore recognized as two privileged scaffolds in drug discovery. In the present study, 24 3′,4′-dihydro-2′H-
Maloba M. M. Lobe, Simon M. N. Efange
doaj   +1 more source

Utilizing MEDT analysis of [3 + 2] cycloaddition reaction: x-ray crystallography of spirooxindole linked with thiophene/furan heterocycles and triazole framework [PDF]

BMC Chem
Abdulmajeed Abdullah Alayyaf, Mohd Sajid Ali, Moayad Abdullah Alwehaibi, Muhanna K. Al‐Muhanna, Saied M. Soliman, Mar Ríos‐Gutiérrez, Matti Haukka, Assem Barakat   +7 more
openalex   +2 more sources

3′-Methyl-2-oxo-1′,5′-diphenyl-1′,7′-dihydrospiro[indoline-3,4′-pyrazolo[3,4-b]pyridine]-6′-carboxylic Acid

Molbank, 2021
3′-methyl-2-oxo-1′,5′-diphenyl-1′,7′-dihydrospiro[indoline-3,4′-pyrazolo[3,4-b]pyridine]-6′-carboxylic acid was synthesized using diverse conditions. The best reaction condition consisted of using water as solvent under microwave irradiation, affording ...
Pablo E. Romo, Braulio Insuasty, Jairo Quiroga, Rodrigo Abonia   +3 more
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Synthesis and Diversification of Chiral Spirooxindoles via Organocatalytic Cascade Reactions

Chemistry Proceedings, 2023
The synthesis of chiral spirooxindoles through different amino catalytic activation modes is described herein. Several alkenylisatins were obtained from the Knoevenagel reaction of isatin and activated methylene derivatives containing electron ...
Jessica Navarro Vega, David Cruz Cruz, Clarisa Villegas Gómez   +2 more
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3,3-Bis(hydroxyaryl)oxindoles and Spirooxindoles Bearing a Xanthene Moiety: Synthesis, Mechanism, and Biological Activity [PDF]

J Org Chem
Dániel Steinsits, Bettina Rávai, Zsolt Kelemen, László Hackler, Viktor Vernyik, László G. Puskás, Erika Bálint   +6 more
openalex   +2 more sources

Enantioselective Synthesis of Spiro[indolizidine-1,3 '-oxindoles] [PDF]

, 2020
A three-step procedure for the enantioselective synthesis of spiro[indolizidine-1,3'-oxindoles], consisting of a stereoselective cyclocondensation reaction between (S)-tryptophanol and a prochiral or racemic 5-oxoester, bromination of the resulting ...
Amat Tusón, Mercedes, Bosch Cartes, Joan, Gazzola, Silvia, Luque Garriga, F. Xavier, Massi, Lucia, Molins i Grau, Elies, Pérez Bosch, Maria, Ramos, Carlos, Taglienti, Chiara, Viayna Gaza, Antonio, Yayik, Nihan   +10 more
core   +1 more source

Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity [PDF]

, 2021
Multicomponent reactions (MCRs) are a valuable tool in diversity-oriented synthesis. Its application to privileged structures is gaining relevance in the fields of organic and medicinal chemistry.
Brandão, Pedro, Burke, Anthony J., Carreiro, Elisabete P., Marques, Carolina S., Pineiro, Marta   +4 more
core   +1 more source

Studies on the Enantioselective Synthesis of E-Ethylidene-bearing Spiro[indolizidine-1,3′-oxindole] Alkaloids [PDF]

, 2021
A synthetic route for the enantioselective construction of the tetracyclic spiro[indolizidine-1,3'-oxindole] framework present in a large number of oxindole alkaloids, with a cis H-3/H-15 stereochemistry, a functionalized two-carbon substituent at C-15 ...
Amat Tusón, Mercedes, Bosch Cartes, Joan, Molins i Grau, Elies, Pérez Bosch, Maria, Yayik, Nihan   +4 more
core   +1 more source

New spirooxindole pyrrolidine/pyrrolizidine analogs: design, synthesis, and evaluation as an anticancer agent [PDF]

RSC Adv
Narayanasamy Nivetha, Janarthanan Venkatesan, Dhanashree Murugan, Loganathan Rangasamy, Shu‐Pao Wu, Sivan Velmathi   +5 more
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The Solubility Studies and the Complexation Mechanism Investigations of Biologically Active Spiro[cyclopropane-1,3′-oxindoles] with β-Cyclodextrins

Pharmaceutics, 2023
In this work, we first improved the aqueous solubility of biologically active spiro[cyclopropane-1,3′-oxindoles] (SCOs) via their complexation with different β-cyclodextrins (β-CDs) and proposed a possible mechanism of the complex formation.
Anna A. Kravtsova, Anna A. Skuredina, Alexander S. Malyshev, Irina M. Le-Deygen, Elena V. Kudryashova, Ekaterina M. Budynina   +5 more
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