Results 41 to 50 of about 4,752 (252)

Nanoformulation of Spirooxindole and Methods for Treating Hepatocellular Carcinoma

Pharmaceutics
Objectives: This in vivo study introduces a newly developed spirooxindole derivative that is deemed safe and effective as a potential targeted therapy for various cancers. Methods: Extensive in vivo investigations, including histopathology, immunohistochemistry, and molecular biology, validated its potential for further preclinical and clinical ...
Assem Barakat, Fardous F. El‐Senduny, Mohammad Shahidul Islam, Abdullah Mohammed Al‐Majid, Yaseen A. M. M. Elshaier, Eman A. Mazyed, Farid A. Badria   +6 more
openalex   +3 more sources

New spirooxindole pyrrolidine/pyrrolizidine analogs: design, synthesis, and evaluation as an anticancer agent. [PDF]

RSC Adv
Nivetha N, Venkatesan J, Murugan D, Rangasamy L, Wu SP, Velmathi S.   +5 more
europepmc   +2 more sources

Utilizing MEDT analysis of [3 + 2] cycloaddition reaction: x-ray crystallography of spirooxindole linked with thiophene/furan heterocycles and triazole framework. [PDF]

BMC Chem
Alayyaf AA, Ali M, Alwehaibi MA, Al-Muhanna MK, Soliman SM, Ríos-Gutiérrez M, Haukka M, Barakat A.   +7 more
europepmc   +2 more sources

Potent EGFR/PARP-1 inhibition by spirooxindole-triazole hybrids for targeted liver cancer therapy. [PDF]

RSC Adv
Nafie MS, Ali M, Alwehaibi MA, Alayyaf AA, Al-Muhanna MK, Almuqati NS, Alghamdi AA, Haukka M, Tariq SS, Ul-Haq Z, Barakat A.   +10 more
europepmc   +2 more sources

B(iii)-catalyzed synthesis of spirooxindole and dihydro-2-oxopyrrole under solventless conditions in a ball mill, along with DFT computations. [PDF]

RSC Adv
Mallah D, Mirjalili BBF, Basharnavaz H, Bamoniri A.   +3 more
europepmc   +2 more sources

3,3-Bis(hydroxyaryl)oxindoles and Spirooxindoles Bearing a Xanthene Moiety: Synthesis, Mechanism, and Biological Activity. [PDF]

J Org Chem
Steinsits D, Rávai B, Kelemen Z, Hackler L, Vernyik V, Puskás LG, Bálint E.   +6 more
europepmc   +2 more sources

Asymmetric Organocatalytic Synthesis of aza-Spirocyclic Compounds from Isothiocyanates and Isocyanides [PDF]

, 2021
The spirocyclic motif is present in natural products, chiral ligands, and compounds of pharmacological interest. Isothiocyanates as well as isocyanides bearing electron-withdrawing groups in the α-position can be deprotonated and react as formal dipoles ...
Blay Llinares, Gonzalo, Laviós, Adrián, Pedro, José Ramón, Sanz Marco, Amparo, Vila Descals, Carlos   +4 more
core   +1 more source

Highly diastereoselective cascade [5 + 1] double Michael reaction, a route for the synthesis of spiro(thio)oxindoles

Scientific Reports, 2021
The first diastereoselective synthesis of spirothiooxindoles is reported via the Michael reaction between thiooxindoles and dibenzalacetones. The reaction was conducted without any catalyst or additive under green conditions, i.e., ethanol as the solvent
Firouz Matloubi Moghaddam, Vahid Saberi, Ashkan Karimi   +2 more
doaj   +1 more source

3′-Methyl-2-oxo-1′,5′-diphenyl-1′,7′-dihydrospiro[indoline-3,4′-pyrazolo[3,4-b]pyridine]-6′-carboxylic Acid

Molbank, 2021
3′-methyl-2-oxo-1′,5′-diphenyl-1′,7′-dihydrospiro[indoline-3,4′-pyrazolo[3,4-b]pyridine]-6′-carboxylic acid was synthesized using diverse conditions. The best reaction condition consisted of using water as solvent under microwave irradiation, affording ...
Pablo E. Romo, Braulio Insuasty, Jairo Quiroga, Rodrigo Abonia   +3 more
doaj   +1 more source

3′,4′-Dihydro-2′H-spiro[indoline-3,1′-isoquinolin]-2-ones as potential anti-cancer agents: synthesis and preliminary screening [PDF]

Royal Society Open Science, 2020
Both tetrahydroisoquinolines (THIQs) and oxindoles (OXs) display a broad range of biological activities including anti-cancer activity, and are therefore recognized as two privileged scaffolds in drug discovery. In the present study, 24 3′,4′-dihydro-2′H-
Maloba M. M. Lobe, Simon M. N. Efange
doaj   +1 more source