Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity [PDF]
, 2021 Multicomponent reactions (MCRs) are a valuable tool in diversity-oriented synthesis. Its application to privileged structures is gaining relevance in the fields of organic and medicinal chemistry.
Brandão, Pedro +4 more
core +1 more source
Deep Eutectic Solvents: The Organic Reaction Medium of the Century [PDF]
, 2016 This microreview summarizes the use of deep eutectic solvents (DESs) and related melts in organic synthesis. Solvents of this type combine the great advantages of other proposed environmentally benign alternative solvents, such as low toxicity, high ...
Abbott +192 more
core +2 more sources
Recent Advances in Biocatalytic Promiscuity: Hydrolase-Catalyzed Reactions for Nonconventional Transformations [PDF]
, 2015 Financial support from the Spanish Ministerio de Economía y Competitividad (CTQ2013-44153-P) is grateful acknowledged. M.L.-I.
Gotor Fernández, Vicente +1 more
core +2 more sources
Stereoselective synthesis of tetrahydroindolizines via catalytic formation of pyridinium ylides from diazo compounds [PDF]
, 2016 Commercially available iron (III) and copper (I) complexes catalyze new multicomponent cycloadditions between diazo compounds, pyridines and electrophilic alkenes to give alkaloid-inspired tetrahydroindolizidines in high yields and diastereoselectivities.
Aggarwal +29 more
core +1 more source
Studies on the Enantioselective Synthesis of E-Ethylidene-bearing Spiro[indolizidine-1,3′-oxindole] Alkaloids [PDF]
, 2021 A synthetic route for the enantioselective construction of the tetracyclic spiro[indolizidine-1,3'-oxindole] framework present in a large number of oxindole alkaloids, with a cis H-3/H-15 stereochemistry, a functionalized two-carbon substituent at C-15 ...
Amat Tusón, Mercedes +4 more
core +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 Triple-negative breast cancer (TNBC) is a highly aggressive malignancy with limited treatment options due to its heterogeneity and the lack of well-defined molecular targets.
Wagdy M. Eldehna +5 more
doaj +1 more source
A synergetic effect of sonication with yolk-shell nanocatalyst for green synthesis of spirooxindoles
Green Chemistry Letters and Reviews, 2021 A synergetic effect of ultrasonic irradiation and yolk–shell nanocatalyst was examined for the synthesis of spirooxindoles from isatin, malononitrile and cyclohexanone.
Somaye Mohammadi, Hossein Naeimi
doaj +1 more source
Molecules, 2023 A microwave-promoted multicomponent reaction of isatins, α-amino acids and 1,4-dihydro-1,4-epoxynaphthalene is achieved under environmentally friendly conditions, delivering oxygen-bridged spirooxindoles within 15 min in good to excellent yields.
Yaojing Shi, Hua Zhao, Yufen Zhao
doaj +1 more source
Organocatalyzed Asymmetric Reaction Using α-Isothiocyanato Compounds [PDF]
, 2016 Organocatalyzed asymmetric reaction using α-isothiocyanato compounds has received much attention in the past 5 years, and significant progress has been made for three types of isothiocyanato compounds, including α-isothiocyanato amides, esters, and ...
Chen, Yong-Zheng +4 more
core +2 more sources
Sonochemical multi-component synthesis of spirooxindoles
Ultrasonics Sonochemistry, 2011 New and efficient multi-component methods have been developed for the synthesis of spirooxindoles in the presence of a catalytic amount of p-TSA as an inexpensive and available catalyst in EtOH under ultrasound irradiation. The method is simple, starts from readily accessible commercial starting materials, and provides biologically interesting products
Minoo, Dabiri +3 more
openaire +2 more sources