Results 61 to 70 of about 3,124 (225)

Photochemical aryl radical cyclizations to give (E)-3-Ylideneoxindoles [PDF]

, 2014
(E)-3-Ylideneoxindoles are prepared in methanol in reasonable to good yields, as adducts of photochemical 5-exo-trig of aryl radicals, in contrast to previously reported analogous radical cyclizations initiated by tris(trimethylsilyl)silane and azo ...
Aldabbagh, Fawaz, Allart-Simon, Ingrid, Gerard, Stephane, Gurry, Michael, McArdle, Patrick, Sapi, Janos   +5 more
core   +2 more sources

Highly Diastereoselective Multicomponent Synthesis of Spirocyclopropyl Oxindoles Enabled by Rare-Earth Metal Salts [PDF]

, 2023
The synthesis of polysubstituted spirocyclopropyl oxindoles using a series of rare-earth metal (REM) salts is reported. REMs, in particular Sc(OTf)3, allowed access to the target compounds by a multicomponent reaction with high diastereoselectivity (≤94 ...
Algiero, Vincenzo, Costanzo, Paola, De Nino, Antonio, Jiménez Barbero, Jesús, Jiménez Oses, Gonzalo, Jiritano, Antonio, Maiuolo, Loredana, Moure, Maria J., Navo, Claudio D., Olivito, Fabrizio, Poveda, Ana, Tallarida, Matteo A.   +11 more
core   +1 more source

Efficient and green pathway for one-pot synthesis of spirooxindoles in the presence of CuO nanoparticles

Green Chemistry Letters and Reviews, 2017
In this research, a new, green and eco-friendly method for the synthesis of spirooxindole derivatives was presented. The reaction was performed at room temperature in the presence of catalytic amounts (4 mol.%) of CuO nanoparticles and products were ...
Leila Moradi, Zeynab Ataei
doaj   +1 more source

Synthesis, characterization and thermal decomposition of 2’-amino-6’-(1H-indol-3-yl)-1-methyl-2-oxospiro-[indoline-3,4’-pyran]-3’,5’-dicarbonitrile under non-isothermal condition in nitrogen atmosphere [PDF]

, 2016
The kinetics and decomposition of a new spirooxindole compound, 2’-amino-6’-(1H-indol-3-yl)-1-methyl-2-oxospiro[indoline-3,4’-pyran]-3’,5’-dicarbonitrile was studied by thermo gravimetric technique under non-isothermal conditions.
Jayachandramani, Natesan, Manikandan, Govindasamy, Nalini, Ganesan, Suresh, Radhakrishnan, Thanikachalam, Venugopal   +4 more
core   +1 more source

Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an update

Beilstein Journal of Organic Chemistry, 2016
Oxindole scaffolds are prevalent in natural products and have been recognized as privileged substructures in new drug discovery. Several oxindole-containing compounds have advanced into clinical trials for the treatment of different diseases. Among these
Bin Yu, Hui Xing, De-Quan Yu, Hong-Min Liu   +3 more
doaj   +1 more source

Molecular Iodine Catalysed One Pot Synthesis of Spirooxindoles by Tandem Knoevenagel Cyclisation [PDF]

, 2021
Spirooxindoles are heterocycles found in various natural and synthetic products with potent bio-, physio-, and pharmaceutical activities. Heterocyclic fused phthalazines possess   antimicrobial, antifungal, anticancer, anti- inflammatory, and ...
Anitha Varghese, Aatika Nizam
core   +2 more sources

Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity [PDF]

, 2022
© 2022 Published by Elsevier Masson SAS.Malaria remains a prevalent infectious disease in developing countries. The first-line therapeutic options are based on combinations of fast-acting artemisinin derivatives and longer-acting synthetic drugs. However,
Fontinha, Diana, Legac, Jenny, Lehane, Adele M., Lopes, Elizabeth A., Mestre, Raquel, Mori, Mattia, Pei, Jinxin V., Prudêncio, Miguel, Rosenthal, Philip J., Sanches-Vaz, Margarida, Santos, Maria M. M.   +10 more
core   +1 more source

Synthesis of new functionalized thiazolo pyridine-fused and thiazolo pyridopyrimidine-fused spirooxindoles via one-pot reactions

Heliyon, 2020
A sequential multi-component reaction of the nitroketene dithioacetals, cysteamine hydrochloride, isatin and different CH-acids is described. This efficient method provides new functionalized thiazolo pyridine-fused spirooxindoles and thiazolo ...
Shima Nasri, Mohammad Bayat, Hassan Vasheghani Farahani, Solmaz Karami   +3 more
doaj  

An Expedient Regio- and Diastereoselective Synthesis of Hybrid Frameworks with Embedded Spiro[9,10]dihydroanthracene [9,3′]-pyrrolidine and Spiro[oxindole-3,2′-pyrrolidine] Motifs via an Ionic Liquid-Mediated Multicomponent Reaction

Molecules, 2015
A series of hitherto unreported anthracene-embedded dispirooxindoles has been synthesized via a one-pot three-component 1,3-dipolar cycloaddition reaction of an azomethine ylide, generated in situ from the reaction of isatin and sarcosine to 10 ...
Natarajan Arumugam, Abdulrahman I. Almansour, Raju Suresh Kumar, J. Carlos Menéndez, Mujeeb A. Sultan, Usama Karama, Hazem A. Ghabbour, Hoong-Kun Fun   +7 more
doaj   +1 more source

Mechanochemical Activation of NaHCO3: A Solid CO2 Surrogate in Carboxylation Reactions

ChemSusChem, EarlyView.
This study presents sodium bicarbonate (NaHCO3) as a safe, solid source of CO2 for mechanochemical carboxylation reactions. Mechanochemical methods for synthesizing cyclic carbamates and organic carbonates from NaHCO3 are developed. This approach holds significant potential for pharmaceutical applications, highlighting solvent‐minimized synthesis and ...
Francesco Mele, Andrea Aquilini, Ana Maria Constantin, Francesco Pancrazzi, Lara Righi, Andrea Porcheddu, Raimondo Maggi, Daniele Alessandro Cauzzi, Giovanni Maestri, Elena Motti, Luca Capaldo, Nicola Della Ca'   +11 more
wiley   +1 more source