Results 61 to 70 of about 3,294 (234)

Therapeutic Potential of Spirooxindoles as Antiviral Agents [PDF]

ACS Infectious Diseases, 2016
Antiviral therapeutics with profiles of high potency, low resistance, panserotype, and low toxicity remain challenging, and obtaining such agents continues to be an active area of therapeutic development. Due to their unique three-dimensional structural features, spirooxindoles have been identified as privileged chemotypes for antiviral drug ...
Na, Ye, Haiying, Chen, Eric A, Wold, Pei-Yong, Shi, Jia, Zhou   +4 more
openaire   +2 more sources

Synthesis, characterization and thermal decomposition of 2’-amino-6’-(1H-indol-3-yl)-1-methyl-2-oxospiro-[indoline-3,4’-pyran]-3’,5’-dicarbonitrile under non-isothermal condition in nitrogen atmosphere [PDF]

, 2016
The kinetics and decomposition of a new spirooxindole compound, 2’-amino-6’-(1H-indol-3-yl)-1-methyl-2-oxospiro[indoline-3,4’-pyran]-3’,5’-dicarbonitrile was studied by thermo gravimetric technique under non-isothermal conditions.
Jayachandramani, Natesan, Manikandan, Govindasamy, Nalini, Ganesan, Suresh, Radhakrishnan, Thanikachalam, Venugopal   +4 more
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Green Synthesis of Spiro Compounds with Potential Anticancer Activity through Knoevenagel/Michael/Cyclization Multicomponent Domino Reactions Organocatalyzed by Ionic Liquid and Microwave-Assisted [PDF]

, 2022
In this work a microwave-assisted Knoevenagel/Michael/cyclization multicomponent domino methodology, using ethanol as solvent and the ionic liquid 1-methylimidazolium chloride as catalyst was developed for the synthesis of spiro compounds.
Campos V. R., Fiorot R. G., Greco S. J., Guimaraes C. D. J., Loureiro L. B., Manso M. P., Medici F., Pessoa C., Resende J. A. L. C., Tormena C. F., Venturini Filho E., Westphal R.   +11 more
core   +1 more source

An Expedient Regio- and Diastereoselective Synthesis of Hybrid Frameworks with Embedded Spiro[9,10]dihydroanthracene [9,3′]-pyrrolidine and Spiro[oxindole-3,2′-pyrrolidine] Motifs via an Ionic Liquid-Mediated Multicomponent Reaction

Molecules, 2015
A series of hitherto unreported anthracene-embedded dispirooxindoles has been synthesized via a one-pot three-component 1,3-dipolar cycloaddition reaction of an azomethine ylide, generated in situ from the reaction of isatin and sarcosine to 10 ...
Natarajan Arumugam, Abdulrahman I. Almansour, Raju Suresh Kumar, J. Carlos Menéndez, Mujeeb A. Sultan, Usama Karama, Hazem A. Ghabbour, Hoong-Kun Fun   +7 more
doaj   +1 more source

Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity [PDF]

, 2022
© 2022 Published by Elsevier Masson SAS.Malaria remains a prevalent infectious disease in developing countries. The first-line therapeutic options are based on combinations of fast-acting artemisinin derivatives and longer-acting synthetic drugs. However,
Fontinha, Diana, Legac, Jenny, Lehane, Adele M., Lopes, Elizabeth A., Mestre, Raquel, Mori, Mattia, Pei, Jinxin V., Prudêncio, Miguel, Rosenthal, Philip J., Sanches-Vaz, Margarida, Santos, Maria M. M.   +10 more
core   +1 more source

Michael Addition-Initiated Sequential Reactions from 1,3-Dicarbonyls for the Synthesis of Polycyclic Heterocycles

, 2013
International audienceThis review aims to highlight the most significant recent developments on synthetic strategies involving consecutive, domino and multicomponent reactions featuring a Michael addition-initiating step for the synthesis of polycyclic ...
Bonne, Damien, Bugaut, Xavier, Constantieux, Thierry, Coquerel, Yoann, Rodriguez, Jean   +4 more
core   +3 more sources

Molecular Iodine Catalysed One Pot Synthesis of Spirooxindoles by Tandem Knoevenagel Cyclisation [PDF]

, 2021
Spirooxindoles are heterocycles found in various natural and synthetic products with potent bio-, physio-, and pharmaceutical activities. Heterocyclic fused phthalazines possess   antimicrobial, antifungal, anticancer, anti- inflammatory, and ...
Anitha Varghese, Aatika Nizam
core   +2 more sources

Regioselective Synthesis of Spiro-Oxindoles via a Ruthenium-Catalyzed Metathesis Reaction

Chemistry Proceedings, 2023
Spiro-oxindoles are important heterocyclic motifs found in various alkaloids, many of which exhibit pharmacological properties. Due to the remarkable biological activity of spiro-oxindoles, significant effort has been made towards the synthesis of ...
Pradip Debnath
doaj   +1 more source

Advances in Enaminomaleimides Chemistry: Synthesis, Chemical Applications, and Perspectives

ChemistryEurope, Volume 3, Issue 5, September 18, 2025.
Enaminomaleimides are versatile building blocks for the construction of functionalized heterocycles. Their unique nucleophilic character, contrasting with the classical electrophilic nature of maleimides, enables diverse synthetic applications, showing promising potential in both materials science and medicinal chemistry.
Adrián López‐Francés, Birane Diop, Xingyu Jiang, Jean Rodriguez, Muriel Amatore, Thierry Constantieux   +5 more
wiley   +1 more source

Синтез і хімічні властивості конденсованих та спіросполучених похідних піролу [PDF]

, 2018
У дисертаційній роботі досліджено стереохімію та регіонаправленість фор-мування продуктів у процесах 1,3-диполярного циклоприєднання азометин-ілідів на основі ізатину та циклічних і аліфатичних α-амінокислот до похідних N-заміщених малеїнімідів ...
Павловська, Т.Л.
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