Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 Triple-negative breast cancer (TNBC) is a highly aggressive malignancy with limited treatment options due to its heterogeneity and the lack of well-defined molecular targets.
Wagdy M. Eldehna +5 more
doaj +1 more source
A synergetic effect of sonication with yolk-shell nanocatalyst for green synthesis of spirooxindoles
Green Chemistry Letters and Reviews, 2021 A synergetic effect of ultrasonic irradiation and yolk–shell nanocatalyst was examined for the synthesis of spirooxindoles from isatin, malononitrile and cyclohexanone.
Somaye Mohammadi, Hossein Naeimi
doaj +1 more source
An evaluation of spirooxindoles as blocking agents of SARS-CoV-2 spike/ACE2 interaction: synthesis, biological evaluation and computational analysis [PDF]
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has gained significant public health attention owing to its devastating effects on lives and livelihoods worldwide.
Albert Enama Ehinak +11 more
openalex +3 more sources
Stereoselective Synthesis of Multifunctional Spirooxindole-Dihydrofuran Derivatives
Polycyclic Aromatic Compounds, 2021 A facile and efficient protocol for the diastereoselective synthesis of novel spirooxindole-dihydrofurans has been developed by the three-component condensation of isatin derivatives, 3-cyanoacetyl indole, and N-phenacylpyridinium bromide in the presence of triethylamine base. The reaction was carried out in ethanol under reflux conditions, and various
Hashem Bagheri +2 more
openaire +2 more sources
Синтез і антимікробна активність гексаметилен-N-малеїнімідопохідних спіроіндол- 3,3’-піроло[3,4-с]піролу [PDF]
, 2017 Aim. To synthesize a series of hexamethylene-N-maleinimidospiroindole-3,3’-pyrrolo[3,4-c]pyrrole derivatives, study the antimicrobial activity of the compounds synthesized and compare their antimicrobial activity with the antimicrobial activity of the ...
Filimonova, N. I. +4 more
core +2 more sources
Green Chemistry Letters and Reviews, 2017 In this research, a new, green and eco-friendly method for the synthesis of spirooxindole derivatives was presented. The reaction was performed at room temperature in the presence of catalytic amounts (4 mol.%) of CuO nanoparticles and products were ...
Leila Moradi, Zeynab Ataei
doaj +1 more source
Stereoselective synthesis of tetrahydroindolizines via catalytic formation of pyridinium ylides from diazo compounds [PDF]
, 2016 Commercially available iron (III) and copper (I) complexes catalyze new multicomponent cycloadditions between diazo compounds, pyridines and electrophilic alkenes to give alkaloid-inspired tetrahydroindolizidines in high yields and diastereoselectivities.
Aggarwal +29 more
core +1 more source
Sonochemical multi-component synthesis of spirooxindoles
Ultrasonics Sonochemistry, 2011 New and efficient multi-component methods have been developed for the synthesis of spirooxindoles in the presence of a catalytic amount of p-TSA as an inexpensive and available catalyst in EtOH under ultrasound irradiation. The method is simple, starts from readily accessible commercial starting materials, and provides biologically interesting products
Ayoob Bazgir +3 more
openaire +3 more sources
Metal-Free Diastereo- and Enantioselective Dearomative Formal [3+2] Cycloaddition of 2-Nitrobenzofurans and Isocyanoacetate Esters [PDF]
, 2022 [EN] The diastereo- and enantioselective dearomative formal [3 + 2] cycloaddition of 2-nitrobenzofurans and alpha-aryl-alpha isocyanoacetate esters provides tricyclic compounds bearing the 3a,8b-dihydro-1H-benzofuro[2,3-c]pyrrole framework with three ...
Blay, Gonzalo +5 more
core +4 more sources
Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an update
Beilstein Journal of Organic Chemistry, 2016 Oxindole scaffolds are prevalent in natural products and have been recognized as privileged substructures in new drug discovery. Several oxindole-containing compounds have advanced into clinical trials for the treatment of different diseases. Among these
Bin Yu +3 more
doaj +1 more source