Results 71 to 80 of about 3,294 (234)
Catalytic Enantioselective Construction of Quaternary Stereocenters: Assembly of Key Building Blocks for the Synthesis of Biologically Active Molecules [PDF]
, 2015 The ever-present demand for drugs with better efficacy and fewer side effects continually motivates scientists to explore the vast chemical space. Traditionally, medicinal chemists have focused much attention on achiral or so-called “flat” molecules ...
Han, Seo-Jung +3 more
core +1 more source
TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation [PDF]
, 2016 Non-genotoxic reactivation of the p53 pathway by MDM2-p53 binding antagonists is an attractive treatment strategy for wild-type TP53 cancers. To determine how resistance to MDM2/p53 binding antagonists might develop, SJSA-1 and NGP cells were exposed to ...
Bennaceur, Karim +14 more
core +3 more sources
Highly Diastereoselective Multicomponent Synthesis of Spirocyclopropyl Oxindoles Enabled by Rare-Earth Metal Salts [PDF]
, 2023 The synthesis of polysubstituted spirocyclopropyl oxindoles using a series of rare-earth metal (REM) salts is reported. REMs, in particular Sc(OTf)3, allowed access to the target compounds by a multicomponent reaction with high diastereoselectivity (≤94 ...
Algiero, Vincenzo +11 more
core +1 more source
A novel one-pot synthesis of spirooxindole derivatives catalyzed by nano ZnO
Bulletin of the Chemical Society of Ethiopia, 2013 Nano zinc oxide was explored as a heterogeneous and reusable catalyst for the one-pot synthesis of spirooxindoles via three-component reaction between urea, isatin, and 1,3-dicarbonyl compounds.
B. Baghernejad, M. Khorshidi
doaj +1 more source
Angewandte Chemie, Volume 137, Issue 33, August 11, 2025.A binary organic–inorganic acid cooperative catalytic system has been developed to achieve highly enantioselective electrochemical oxidative rearrangement of indoles. The use of electricity as an oxidant in this case showed several advantages including environmental benignity and improved enantiocontrol.
Xuefeng Tan +3 more
wiley +1 more source
Molecules, 2023 A novel series of nitrostyrene-based spirooxindoles were synthesized via the reaction of substituted isatins 1a–b, a number of α-amino acids 2a–e and (E)-2-aryl-1-nitroethenes 3a–e in a chemo/regio-selective manner using [3+2] cycloaddition (Huisgen ...
Richa Sharma +12 more
doaj +1 more source
Stereoselective Synthesis of Spirooxindole Amides through Nitrile Hydrozirconation [PDF]
Organic Letters, 2010 Spirooxindole amides can be prepared by the intramolecular addition of functionalized indoles into acylimines that are accessed from nitriles by hydrozirconation and acylation. The stereochemical outcome at the quaternary center was controlled by the steric bulk of the substituent at the 2-position of the indole unit.
Chunliang, Lu +2 more
openaire +2 more sources
Asymmetric 1,3-Dipolar Cycloadditons of Stabilized Azomethine Ylides with Nitroalkenes [PDF]
, 2014 This review highlights the biological importance of many polysubstituted nitro-prolines and -pyrrolidines. Their preparation using asymmetric 1,3-dipolar cycloadditions of azomethine ylides with nitroalkenes using diastereoselective and enantioselective ...
Nájera, Carmen, Sansano, Jose M.
core +2 more sources
Beilstein Journal of Organic Chemistry, 2014 Simple primary-tertiary diamines easily derived from natural primary amino acids were used to catalyze the Michael addition of ketones with isatylidenemalononitrile derivatives. Diamine 1a in combination with D-CSA as an additive provided Michael adducts
Akshay Kumar, Swapandeep Singh Chimni
doaj +1 more source
Construction of Spirooxindole Skeleton Through Intramolecular Dieckmann Cyclization
Natural Products and Bioprospecting, 2017 A highly efficient and direct approach was developed to construct the structurally diverse spirooxindole skeleton, which is an important basic motif in natural products.
Ting Wu, Zhiqiang Pan, Chengfeng Xia
doaj +1 more source