Results 81 to 90 of about 4,752 (252)

TCCA-mediated oxidative rearrangement of tetrahydro-β-carbolines: facile access to spirooxindoles and the total synthesis of (±)-coerulescine and (±)-horsfiline

open access: yesRSC Advances, 2021
Multi-reactive centered reagents are beneficial in chemical synthesis due to their advantage of minimal material utilization and formation of less by-products.
M. Sathish   +4 more
semanticscholar   +1 more source

Michael Addition-Initiated Sequential Reactions from 1,3-Dicarbonyls for the Synthesis of Polycyclic Heterocycles

open access: yes, 2013
International audienceThis review aims to highlight the most significant recent developments on synthetic strategies involving consecutive, domino and multicomponent reactions featuring a Michael addition-initiating step for the synthesis of polycyclic ...
Bonne, Damien   +4 more
core   +3 more sources

Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity [PDF]

open access: yes, 2022
© 2022 Published by Elsevier Masson SAS.Malaria remains a prevalent infectious disease in developing countries. The first-line therapeutic options are based on combinations of fast-acting artemisinin derivatives and longer-acting synthetic drugs. However,
Fontinha, Diana   +10 more
core   +1 more source

Recent Advances in Biocatalytic Promiscuity: Hydrolase-Catalyzed Reactions for Nonconventional Transformations [PDF]

open access: yes, 2015
Financial support from the Spanish Ministerio de Economía y Competitividad (CTQ2013-44153-P) is grateful acknowledged. M.L.-I.
Gotor Fernández, Vicente   +1 more
core   +2 more sources

A novel one-pot synthesis of spirooxindole derivatives catalyzed by nano ZnO

open access: yesBulletin of the Chemical Society of Ethiopia, 2013
Nano zinc oxide was explored as a heterogeneous and reusable catalyst for the one-pot synthesis of spirooxindoles via three-component reaction between urea, isatin, and 1,3-dicarbonyl compounds.
B. Baghernejad, M. Khorshidi
doaj   +1 more source

Regioselective Synthesis of Spiro-Oxindoles via a Ruthenium-Catalyzed Metathesis Reaction

open access: yesChemistry Proceedings, 2023
Spiro-oxindoles are important heterocyclic motifs found in various alkaloids, many of which exhibit pharmacological properties. Due to the remarkable biological activity of spiro-oxindoles, significant effort has been made towards the synthesis of ...
Pradip Debnath
doaj   +1 more source

Electrochemical Enantioselective Oxidation of Indoles via Chiral Phosphoric Acid Catalysis in Cooperation with H3PO4 in Aqueous Media

open access: yesAngewandte Chemie International Edition, EarlyView.
A binary organic–inorganic acid cooperative catalytic system has been developed to achieve highly enantioselective electrochemical oxidative rearrangement of indoles. The use of electricity as an oxidant in this case showed several advantages including environmental benignity and improved enantiocontrol.
Xuefeng Tan   +3 more
wiley   +1 more source

The regioselective synthesis of spirooxindolo pyrrolidines and pyrrolizidines via three-component reactions of acrylamides and aroylacrylic acids with isatins and α-amino acids

open access: yesBeilstein Journal of Organic Chemistry, 2014
The regioselective three-component condensation of azomethine ylides derived from isatins and α-amino acids with acrylamides or aroylacrylic acids as dipolarophiles has been realized through a one-pot 1,3-dipolar cycloaddition protocol.
Tatyana L. Pavlovskaya   +6 more
doaj   +1 more source

Mechanochemical Activation of NaHCO3: A Solid CO2 Surrogate in Carboxylation Reactions

open access: yesChemSusChem, Volume 18, Issue 14, July 17, 2025.
This study presents sodium bicarbonate (NaHCO3) as a safe, solid source of CO2 for mechanochemical carboxylation reactions. Mechanochemical methods for synthesizing cyclic carbamates and organic carbonates from NaHCO3 are developed. This approach holds significant potential for pharmaceutical applications, highlighting solvent‐minimized synthesis and ...
Francesco Mele   +11 more
wiley   +1 more source

Primary-tertiary diamine-catalyzed Michael addition of ketones to isatylidenemalononitrile derivatives

open access: yesBeilstein Journal of Organic Chemistry, 2014
Simple primary-tertiary diamines easily derived from natural primary amino acids were used to catalyze the Michael addition of ketones with isatylidenemalononitrile derivatives. Diamine 1a in combination with D-CSA as an additive provided Michael adducts
Akshay Kumar, Swapandeep Singh Chimni
doaj   +1 more source

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