Results 81 to 90 of about 3,124 (225)

Microwave‐Assisted Multicomponent Synthesis of Spirooxindole Dihydropyridine Bisphosphonates

European Journal of Organic Chemistry, Volume 28, Issue 6, February 10, 2025.
A new, simple, catalyst‐ and solvent‐free microwave‐assisted multicomponent method was developed for the synthesis of spirooxindole dihydropyridine bisphosphonates as a new family of compounds by the one‐pot reaction of isatins, β‐ketophosphonates and primary amines.
Bettina Rávai, Áron Soma Németh, Zsolt Kelemen, Erika Bálint   +3 more
wiley   +1 more source

The regioselective synthesis of spirooxindolo pyrrolidines and pyrrolizidines via three-component reactions of acrylamides and aroylacrylic acids with isatins and α-amino acids

Beilstein Journal of Organic Chemistry, 2014
The regioselective three-component condensation of azomethine ylides derived from isatins and α-amino acids with acrylamides or aroylacrylic acids as dipolarophiles has been realized through a one-pot 1,3-dipolar cycloaddition protocol.
Tatyana L. Pavlovskaya, Fedor G. Yaremenko, Victoria V. Lipson, Svetlana V. Shishkina, Oleg V. Shishkin, Vladimir I. Musatov, Alexander S. Karpenko   +6 more
doaj   +1 more source

Stereoselective N‐Heterocyclic‐Carbene‐Catalyzed Spiroannulation as an Access Towards Spirobenzofuranone‐Fused Cyclohexenones

Advanced Synthesis &Catalysis, Volume 366, Issue 24, Page 5008-5014, December 17, 2024.
Abstract In this work, we present an organocatalytic spiroannulation method that provides access to spirocyclic benzofuran‐2‐ones. The reaction proceeds via the generation of an azolium dienolate from an α‐bromo‐α,β‐unsaturated aldehyde using a chiral N‐heterocyclic carbene, followed by annulation with benzofuran‐2‐one‐derived alkenes.
Ladislav Lóška, Vojtěch Dočekal, Daniel Čermák, Simona Petrželová, Milan Pour, Ivana Císařová, Klára Konečná, Ondřej Janďourek, Jan Veselý   +8 more
wiley   +1 more source

Organocatalyzed Asymmetric Cascade Michael/Michael Reaction of α‐Alkylidene Succinimides with a 2‐(Trifluoromethylmethylene)indane‐1,3‐dione

European Journal of Organic Chemistry, Volume 27, Issue 41, November 4, 2024.
A diaminomethylenemalononitrile organocatalyst promoted asymmetric cascade Michael/Michael reactions between a 2‐(trifluoromethylmethylene)indane‐1,3‐dione derivative and α‐alkylidene succinimides, resulting in spiroindane‐1,3‐dione derivatives.
Ryo Tsuyusaki, Kosuke Nakashima, Yasuyuki Matsushima, Shin‐ichi Hirashima, Tsuyoshi Miura   +4 more
wiley   +1 more source

Synthesis of 1,2,3-Triazole 5-Chloroisatin Derivatives via Copper-Catalyzed 1,3-Dipolar Cycloaddition Reactions [PDF]

, 2017
A facile and simple protocol for the ‘Click\u27 cycloaddition of organic azides with N-propargylchloroisatine catalyzed by CuI, produces in good yields novel of 1,4-disubstituted 1,2,3-triazoles were obtained.
Rodi, Y. K. (Y), Senhaji, O. (O), Skalli, M. K. (M), Tribak, Z. (Z)   +3 more
core   +1 more source

Recent Advances in the Application of 2‐Aminobenzothiazole to the Multicomponent Synthesis of Heterocycles

ChemistryOpen, Volume 13, Issue 11, November 2024.
This review highlights recent advances in multicomponent reactions using 2‐aminobenzothiazole as a starting material in the synthesis of diverse heterocycles. These reactions enable the efficient and sustainable construction of novel bioactive molecules and pharmaceuticals.
Ramin Javahershenas, Jianlin Han, Mosstafa Kazemi, Peter J. Jervis   +3 more
wiley   +1 more source

Michael Addition-Initiated Sequential Reactions from 1,3-Dicarbonyls for the Synthesis of Polycyclic Heterocycles

, 2013
International audienceThis review aims to highlight the most significant recent developments on synthetic strategies involving consecutive, domino and multicomponent reactions featuring a Michael addition-initiating step for the synthesis of polycyclic ...
Bonne, Damien, Bugaut, Xavier, Constantieux, Thierry, Coquerel, Yoann, Rodriguez, Jean   +4 more
core   +3 more sources

Recent Advances in Biocatalytic Promiscuity: Hydrolase-Catalyzed Reactions for Nonconventional Transformations [PDF]

, 2015
Financial support from the Spanish Ministerio de Economía y Competitividad (CTQ2013-44153-P) is grateful acknowledged. M.L.-I.
Gotor Fernández, Vicente, López Iglesias, María   +1 more
core   +2 more sources

Synthesis of Fluorinated Spiroindolenines by Transition Metal‐Catalyzed Indole Dearomatizations

Advanced Synthesis &Catalysis, Volume 366, Issue 20, Page 4244-4252, October 25, 2024.
Abstract A strategy to access fluorinated spiroindolenines has been developed, involving a selective functionalization of indoles with fluorinated moieties and subsequent catalytic dearomatization. Trifluomethylthio (SCF3), diethyl phosphono(difluoromethyl)thio (SCF2P(O)(OEt)2) and (phenylsulfonyl)difluoromethyl (CF2SO2Ph) groups were embedded at the ...
Floris Buttard, Meriem Daghmoum, Mathieu Arribat, Mu‐Yi Chen, Pascal Retailleau, Tatiana Besset, Xavier Guinchard   +6 more
wiley   +1 more source

Recent Developments in the Synthesis of Chiral Compounds with Quaternary Centers by Organocatalytic Cascade Reactions [PDF]

, 2016
Quaternary carbon stereocenters are present in a wide variety of organic compounds and drug molecules. Highly enantioselective construction of such quaternary carbon stereocenters has received considerable attention owing to the great challenges in their
Ahrendt, Akiyama, Albertshofer, Albertshofer, Albrecht, Albrecht, Bartoli, Beeson, Bencivenni, Bencivenni, Bertelsen, Birrell, Brak, Burns, Büschleb, Cai, Chauhan, Chen, Chen, Das, Denmark, Du, Enders, Fogg, Halskov, Halskov, Hamilton, Hashimoto, Hawner, Hayashi, Hu, Huang, Iwabuchi, Jia, Jiang, Jiang, Jiang, Jones, Jones, Knowles, Lacour, Laforteza, Lan, Lefranc, Li, Liao, List, Liu, Loh, Lygo, Malerich, Manoni, McCooey, Melchiorre, Nicolaou, Okino, Ooi, Pellissier, Phipps, Qi, Rauniyar, Rendler, Romanov-Michailidis, Sanchez Duque, Shi, Shimizu, Sigman, Sigman, Silvi, Su, Sun, Sun, Tan, Tan, Tan, Tian, Tian, Tian, Tian, Tietze, Uraguchi, Vachal, Volla, Wang, Wei, Wenzel, Wu, Xie, Xu, Yang, Yeung, Yu, Zhang, Zhang, Zhang, Zhao, Zhao, Zhong, Zou   +98 more
core   +1 more source