Results 71 to 80 of about 51,716,445 (167)

CXC Chemokine Receptor 4 Is Expressed Paravascularly in Apical Papilla and Coordinates with Stromal Cell-derived Factor-1 alpha during Transmigration of Stem Cells from Apical Papilla

, 2015
Introduction: Stem cells from the apical papilla (SCAPs) at the apex may be attracted into the root canal space as a cell source for pulp-dentin regeneration.
Zou, Xiao-Ying, Liu, Jing-Yi, Yue, Lin, Huang, George T.J., Chen, Xue   +4 more
core   +1 more source

Betaine enhances SCAPs chondrogenic differentiation and promotes cartilage repair in TMJOA through WDR81

Stem Cell Research & Therapy
Background The cartilage tissue regeneration mediated with mesenchymal stem cells (MSCs) is considered as a viable strategy for temporomandibular joint osteoarthritis (TMJOA). Betaine has been confirmed to modulate the multidirectional differentiation of
Meiyue Wang, Zejie Wu, Xiaoyu Zheng, Yishu Huang, Yizhou Jin, Jiaxin Song, Wanzhen Lei, Hua Liu, Riyue Yu, Haoqing Yang, Runtao Gao   +10 more
doaj   +1 more source

Comparative Secretome Analysis of Mesenchymal Stem Cells From Dental Apical Papilla and Bone Marrow During Early Odonto/Osteogenic Differentiation: Potential Role of Transforming Growth Factor-β2

Frontiers in Physiology, 2020
To understand the functions of secretory proteins in odontogenesis and to further the understanding of the different molecular events during odontogenesis and osteogenesis, we induced the odonto/osteogenic differentiation of stem cells from dental apical
Shi Yu, Jingzhi Li, Yuming Zhao, Xiaoxia Li, Lihong Ge   +4 more
doaj   +1 more source

Polygonati Rhizoma Attenuates Oxidative Stress‐Induced Senescence in Periodontal Ligament Stem Cells

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Network pharmacology identified the potential targets and pathways of Polygonati Rhizoma (PR) against aging‐related periodontitis through PPI, GO/KEGG enrichment, and molecular docking. Experimental validation in a D‐galactose‐induced senescence model of periodontal ligament stem cells showed that PR‐medicated serum attenuated cellular senescence and ...
Xinran Feng, Ying An, Fanfan Hou, Qian Guo, Shanshan Cai, Hongbin Xu, Youfu He   +6 more
wiley   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

3D culture inhibits replicative senescence of SCAPs via UQCRC2-mediated mitochondrial oxidative phosphorylation

Journal of Translational Medicine
Stem cells derived from the apical papilla (SCAPs) play a crucial role in tooth root development and dental pulp regeneration. They are important seed cells for bone/tooth tissue engineering.
Yijia Shi, Tong Xiao, Yingying Weng, Ya Xiao, Jintao Wu, Jing Wang, Wenmin Wang, Maoshen Yan, Ming Yan, Zehan Li, Jinhua Yu   +10 more
doaj   +1 more source

Effect of Intracanal Medications on the Viability of Human Periodontal Ligament‐Derived Mesenchymal Stem Cells

Australian Endodontic Journal, Volume 52, Issue 1, Page 35-45, April 2026.
ABSTRACT This in vitro study evaluated the effects of intracanal medications on the metabolic activity and adhesion of human periodontal ligament‐derived mesenchymal stem cells. Tested groups included Control (without medication), Triple Antibiotic Paste (TAP), Double Antibiotic Paste (DAP), calcium hydroxide with saline, calcium hydroxide with 2 ...
Arian Braido, Walbert de Andrade Vieira, Bruno Cazotti Pereira, Karina Gonzales Silvério, Paulo Henrique Gabriel, Aline Cristine Gomes Matta, Emerson Alves Martins, Adriana de Jesus Soares   +7 more
wiley   +1 more source

Mitochondrial Function Is Required to Preserve Viability of Stem Cells From the Apical Papilla Following Porphyromonas endodontalis Infection

International Endodontic Journal, Volume 59, Issue 2, Page 225-237, February 2026.
ABSTRACT Aims To investigate the effects of Porphyromonas endodontalis on the viability of stem cells from the apical papilla (SCAP) and to explore the role of mitochondrial function in supporting SCAP survival. Methodology SCAP were isolated from immature third molars, and P. endodontalis was added to the cell culture medium.
S. Lei, J. Li, X. C. Wang, S. Yu, A. C. Wang, N. Yang, M. C. Gao, X. Chen   +7 more
wiley   +1 more source

Study on the promotion of osteo/odontogenic differentiation on SCAPs and anti-inflammatory effects of EGCG/CeO2-loaded nanoparticles in an inflammatory microenvironment [PDF]

Kouqiang yixue
Objective To investigate the effects of composite nanoparticles E/Ce@MCSNs loaded with epigallocatechin-3-gallate (EGCG) and cerium dioxide (CeO2) on the odonto/osteogenic differentiation of human stem cells from the apical papilla (SCAPs) and macrophage
WU Yuting, DAI Mingrui, LENG Diya, ZHU Tingting, WU Tao, WU Daming
doaj   +1 more source

From Cells to Animals: Connexin43 Suppression Enhances Autophagic Flux to Restore Odontogenesis in Inflamed Dental Pulp

International Endodontic Journal, Volume 59, Issue 1, Page 134-152, January 2026.
ABSTRACT Aim Under certain conditions, infection‐induced inflammation may activate reparative processes to form a hard tissue barrier against microbial invasion. Autophagy participates in odontogenic differentiation during inflammation in vitro, but its role in pulp repair remains unclear.
Peiling Hu, Yingqing Chen, Ping Long, Anni Zhang, Xiaorong Lan, Yuanpei He, Guangwen Li, Shiting Li   +7 more
wiley   +1 more source