Results 51 to 60 of about 125 (95)

Mitochondrial Function Is Required to Preserve Viability of Stem Cells From the Apical Papilla Following Porphyromonas endodontalis Infection

International Endodontic Journal, Volume 59, Issue 2, Page 225-237, February 2026.
ABSTRACT Aims To investigate the effects of Porphyromonas endodontalis on the viability of stem cells from the apical papilla (SCAP) and to explore the role of mitochondrial function in supporting SCAP survival. Methodology SCAP were isolated from immature third molars, and P. endodontalis was added to the cell culture medium.
S. Lei, J. Li, X. C. Wang, S. Yu, A. C. Wang, N. Yang, M. C. Gao, X. Chen   +7 more
wiley   +1 more source

From Cells to Animals: Connexin43 Suppression Enhances Autophagic Flux to Restore Odontogenesis in Inflamed Dental Pulp

International Endodontic Journal, Volume 59, Issue 1, Page 134-152, January 2026.
ABSTRACT Aim Under certain conditions, infection‐induced inflammation may activate reparative processes to form a hard tissue barrier against microbial invasion. Autophagy participates in odontogenic differentiation during inflammation in vitro, but its role in pulp repair remains unclear.
Peiling Hu, Yingqing Chen, Ping Long, Anni Zhang, Xiaorong Lan, Yuanpei He, Guangwen Li, Shiting Li   +7 more
wiley   +1 more source

3D culture inhibits replicative senescence of SCAPs via UQCRC2-mediated mitochondrial oxidative phosphorylation

Journal of Translational Medicine
Stem cells derived from the apical papilla (SCAPs) play a crucial role in tooth root development and dental pulp regeneration. They are important seed cells for bone/tooth tissue engineering.
Yijia Shi, Tong Xiao, Yingying Weng, Ya Xiao, Jintao Wu, Jing Wang, Wenmin Wang, Maoshen Yan, Ming Yan, Zehan Li, Jinhua Yu   +10 more
doaj   +1 more source

Notch2 is involved in regulating apical tissue repair following severe intrusive luxation [PDF]

Journal of Applied Oral Science
This study aims to characterize apical repair dynamics in immature permanent teeth after severe intrusive luxation, and to explore Notch signaling pathway regulation in this process using a Sprague-Dawley rat model.
Yuanpei He, Xuyan Gong, Cancan Ding, Yang Qiu, Guangwen Li, Shiting Li   +5 more
doaj   +2 more sources

Functionalization of Photocrosslinkable GelMA Hydrogel With Metal Oxides for Direct Pulp Capping

BioMed Research International, Volume 2026, Issue 1, 2026.
Aim In this study, a photocrosslinkable methacrylated gelatin (GelMA) hydrogel, functionalized with metal oxide nanoparticles, was developed to support dentin regeneration in direct pulp capping applications. Magnesium (MgO), silicon (SiO2), strontium (SrO), and zinc (ZnO) were incorporated into GelMA at concentrations of 0.1%, 0.2%, 0.3%, 0.5%, and 1%
Ester Alves Ferreira Bordini, Ligia Espoliar Corrêa, Fernanda Balestrero Cassiano, Érika Soares Bronze-Uhle, Isabela Sanches Pompeo da Silva, Camila Correa da Silva Braga de Melo, Carlos Alberto de Souza Costa, Diana Gabriela Soares, Baisakhi Banerjee   +8 more
wiley   +1 more source

Schisantherin A promotes neural differentiation of stem cells from apical papilla to improve mandibular development via mental nerve repair

Stem Cell Research & Therapy
Background Evidence shows neural involvement in bone remodeling; regulating maxillofacial nerve repair modulates jawbone. Neural stem cell (NSC) therapy is limited by sources/ethics, but neural crest-derived dental mesenchymal stem cells (MSCs) like stem
Lingxi Du, Ailian Li, Ziling Tang, Hanxiang Yang, Xinyu Shi, Shengchao Wang, Zuocheng Qiu, Xuesong Yang, Yue Huang   +8 more
doaj   +1 more source

Endodontic Management of Maxillary Central Incisors With Calcified Canal and Immature Apex Using Static Guide and Amniotic Membrane Plug

Case Reports in Dentistry, Volume 2026, Issue 1, 2026.
Traumatic dental injuries can affect the dental hard tissues, pulp, periodontium, alveolar bone, or gingiva, resulting in long‐term complications such as pulp canal obliteration and the cessation of root development. Such complications often defy conventional endodontic approaches.
Neelam Mittal, Swetha Burugupalli, Vijul, Shelly Sharma, Mohammad Faisal Azeez, Ayushi Kejriwal, Hannah Wesley   +6 more
wiley   +1 more source

Study on the promotion of osteo/odontogenic differentiation on SCAPs and anti-inflammatory effects of EGCG/CeO2-loaded nanoparticles in an inflammatory microenvironment [PDF]

Kouqiang yixue
Objective To investigate the effects of composite nanoparticles E/Ce@MCSNs loaded with epigallocatechin-3-gallate (EGCG) and cerium dioxide (CeO2) on the odonto/osteogenic differentiation of human stem cells from the apical papilla (SCAPs) and macrophage
WU Yuting, DAI Mingrui, LENG Diya, ZHU Tingting, WU Tao, WU Daming
doaj   +1 more source

Regenerative Endodontic Procedure (REP) of a Previously Treated, Infected, Immature Permanent Incisor

Case Reports in Dentistry, Volume 2026, Issue 1, 2026.
The management of immature permanent teeth with pulpal necrosis and prior endodontic failure remains clinically challenging due to incomplete root development, persistent infection, and reduced structural integrity. Regenerative endodontic procedures (REPs) offer a biologically driven alternative to apexification; however, their use in retreatment ...
Heather T. Morris, Patrick Timothy Ruck, Hannah Wesley   +2 more
wiley   +1 more source

The combination of odontogenic stem cells and mandibular advancement promotes the length of the mandible in adult rats by facilitating the development of condylar cartilage

Stem Cell Research & Therapy
Background Mandibular retraction is a prevalent dental and maxillofacial deformity that negatively affects patients' functional health and facial aesthetics.
Xin Cheng, Liangching Huang, Huijuan Wang, SiLong Lei, Chichong Chan, Xuesong Yang, Yue Huang   +6 more
doaj   +1 more source